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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 1
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Research Article

Pharmacokinetic and pharmacodynamic modelling of the alpha adrenoceptor antagonist doxazosin

P. A. Meredith University of Glasgow, Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, UK
,
H. L. Elliott University of Glasgow, Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, UK
,
A. W. Kelman University of Glasgow, Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, UK
,
J. Vincent University of Glasgow, Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, UK
&
J. L. Reid University of Glasgow, Department of Materia Medica, Stobhill General Hospital, Glasgow, G21 3UW, UK
Pages 123-129 | Received 21 Jan 1987, Published online: 22 Sep 2008

References

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  • Elliott H. L., Meredith P. A., Sumner D. J., MacLean K., Reid J. L. Pharmacokinetic pharmacodynamic assessment of a new alpha adrenoceptor antagonist doxazosin (UK 33274) in normotensive subjects. British Journal of Clinical Pharmacology 1982; 13: 699–703
  • Elliott H. L., Meredith P. A., Reid J. L. Comparison of the pharmacokinetics and pharmacodynamics of medroxalol and labetalol. British Journal of Clinical Pharmacology 1984; 17: 573–578
  • Kave B., Cussans N. J., Faulkener J. K., Stopher D. A., Reid J. L. The metabolism and kinetics of doxazosin in man. British Journal of Clinical Pharmacology 1986; 21: 19–26S
  • Meredith P. A., Elliott H. L., Kelman A. W., Reid J. L. Application of pharmacokinetic-pharmacodynamic modelling for the comparison of quinazoline alpha adrenoceptor antagonists in normotensive volunteers. Journal of Cardiovascular Pharmacology 1985; 7: 532–537
  • Meredith P. A., Kelman A. W., Elliott H. L., Reid J. L. Pharmacokinetic and pharmacodynamic modelling of trimazosin and its major metabolite. Journal of Pharmacokinetics and Biopharmaceatics 1983; 11: 323–325
  • Rubin P. C., Brunton J., Meredith P. A. The determination of the vasodilator UK33274 by HPLC using fluorescence detection. Journal of Chromatography 1980; 221: 193–195
  • Sheiner L. B., Stanski D. R., Vozeh S., Miller R. D., Ham J. Simultaneous modelling of pharmacokinetics and dynamics: application of d-tubocurarine. Clinical Pharmacology and Therapeutics 1979; 25: 358–371
  • Singleton W., Saxton C. A., Hernandez J., Prichard B. N. Postjunctional selectivity of alpha-blockade with prazosin, trimazosin and UK33274 in man. Journal of Cardiovascular Pharmacology 1982; 1(Suppl. 1)S145–S151, Vincent, J., Elliott, H. L., Meredith, P. A., and Reid, J. L. 1983, Doxazosin, an alpha1 adrenoceptor antagonist: pharmacokinetics and concentration effect relationship. British Journal of Clinical Pharmacology 15, 719–725

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