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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 8
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Original Article

The fate of 4-cyanoacetanilide in rats and mice; mechanism of formation of a novel electrophilic metabolite

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Pages 955-966 | Received 06 Oct 1987, Accepted 14 Mar 1988, Published online: 30 Sep 2009

References

  • Fischbach T., Lenk W. Additional routes in the metabolism of phenacetin. Xenobiotica 1985; 15: 149–164
  • Fries W., Kiese M., Lenk W. Additional route in the metabolism of sulphanilamide. Xenobiotica 1971; 1: 241–256
  • Grossman S. J., Jollow D. J. Use of the N.I.H. shift to determine the relative contribution in competing pathways of aniline metabolism in the rat. Drug Metabolism and Disposition 1986; 14: 689–691
  • Hutson D. H., Lakeman S. K., Logan C. J. The fate of 4-cyano-N,N-dimethylaniline in rats; a novel involvement of glutathione in the metabolism of anilines. Xenobiotica 1984; 14: 925–934
  • Kiese M., Lenk W. Hydroxylation of N-(4-chlorophenyl) [14C1] acetamide to N-(4-chlorophenyl)[14C1]glycolamide in rabbits. Biochimical Biophysica Acta 1970; 222: 549–551
  • Kiese M., Lenk W. Metabolites of 4-chloroaniline and chloroacetanilides produced by rabbits and pigs. Biochemical Pharmacology 1971; 20: 379–391
  • Logan C. J., Hutson D. H., Hesk D. The fate of 4-cyano-N,N-dimethylaniline in mice: the occurrence of a novel metabolite during N-demethylation of an aromatic amine. Xenobiotica 1985; 15: 391–397
  • Mulder G. J., Scholtens E. Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo, in vitro. Biochemical Journal 1977; 5: 553–559
  • Smith G. E., Griffiths L. A. Comparative metabolic studies of phenacetin and structurally-related compounds in the rat. Xenobiotica 1976; 6: 217–236
  • Parry J. M., Arlett C. F., Ashby J. An overview of the results of the in vivo, in vitro test systems used to assay the genotoxicity of BZD, DAT, DAB and CDA in the second UKEMS collaborative study. Comparative Genetic Toxicoloty, The Second UKEMS Collaborative Study, J. M. Parry, C. F. Arlett. MacMillan, London 1985
  • Vogel A. I. p-Bromoacetanilide. Vogel's Textbook of Practical Organic Chemistry, Edition IV. 1978; 684–685
  • Waters R., Edwards S., Hesk D., Logan C. J. The binding of 4-cyano-N,N-dimethyl-[14C]aniline (CDA) metabolites in the rat. Comparative Genetic Toxicology: The Second UKEMS Collaborative Study, J. M. Parry, C. F. Arlett. MacMillan, London 1985; 533–536
  • Wilson I. D., Macdonald C. M., Fromson J. M., Troke J. A., Hillbeck D. Species differences in the metabolism of 14C-p-trifluoromethylaniline: Production of an oxanilic acid as the major metabolite by the rat. Biochemical Pharmacology 1985; 34: 2025–2028

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