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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 1
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Original Article

The percutaneous fate of the rodenticide flocoumafen in the rat: Role of non-biliary intestinal excretion

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Pages 63-74 | Received 08 Feb 1988, Accepted 22 Aug 1988, Published online: 30 Sep 2009

References

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  • Boylan J. J., Cohn W. J., Egle J. L., Blanke R. V., Guzelian P. S. Excretion of chlordecone by the gastrointestinal tract: evidence for a non biliary mechanism. Clinical Pharmacology and Therapeutics 1979; 25: 579–585
  • Conway W. D., Lee F. H., Neufeld L. Determination of dicoumarol metabolites in bile of rats. Journal of Pharmaceutical Sciences 1975; 64: 1158–1162
  • Dayton P. G., Israili Z. H., Henderson J. D. Elimination of drugs by passive diffusion from blood to intestinal lumen: factors influencing non-biliary excretion by the intestinal tract. Drug Metabolism Reviews 1983; 14: 1193–1206
  • Huckle K. R., Hutson D. H., Logan C. J., Morrison B. J., Warburton P. A. The fate of the rodenticide flocoumafen in the rat: retention and elimination of a single oral dose. Pesticide Science 1988a, in press
  • Huckle K. R., Hutson D. H., Warburton P. A. Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration. Xenobiotica 1988b; 18: 1465–1479
  • Rozman K. Intestinal excretion of toxic substances. Archives of Toxicology 1985, Supplement 8: 87–93, (Receptors and other targets for toxic substances)
  • Sundqvist T., Magnusson R., Sjodhal I., Sternstrom Tagesson C. Passage of molecules through the wall of the gastrointestinal tract. II. Application of low-molecular weight polyethyleneglycol and a deterministic mathematical model for determining intestinal permeability in man. Gut 1980; 21: 208–214
  • Wong L. T., Solomonraj G. Biliary and urinary excretion of (14C) warfarin in rabbits. Xenobiotica 1980; 3: 201–210

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