Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 2
19
Views
21
CrossRef citations to date
0
Altmetric
Original Article

N-oxygenation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent: The role of flavin-containing monooxygenase

, &
Pages 143-150 | Received 15 Jan 1988, Accepted 01 Sep 1988, Published online: 30 Sep 2009

References

  • Beckett A. H., Sheikh A. H. In vitro metabolic N-oxidation of the minor tobacco alkaloids methyl-anabasine and anabasine to yield a hydroxylamine and nitrone in lung and liver homogenates. Journal of Pharmacy and Pharmacology 1973; 25: 171P
  • Cho A. K., Lindeke B., Sum C. Y. The N-hydroxylation of phentermine (2-methyl-2-amino-1-phenylpropane): Properties of the enzyme system. Drug Metabolism and Disposition 1974; 2: 1–8
  • Dannan G. A., Guengerich F. P. Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenase in various hog, mouse, rat, rabbit, dog, and human tissues. Molecular Pharmacology 1982; 22: 787–794
  • Geiger P. J., Bessman S. P. Protein determination by Lowry's method in the presence of sulfhydryl reagents. Analytical Biochemistry 1972; 49: 467–473
  • Gorrod J. W. Differentiation of various types of biological oxidation of nitrogen in organic molecules. Chemico-Biological Interactions 1973; 7: 289–303
  • Gorrod J. W. The current status of the pKa concept in the differentiation of enzymic N-oxidation. Biological Oxidation of Nitrogen, J. W. Gorrod. Elsevier, Amsterdam 1978; 201–210
  • Gorrod J. W., Patterson L. H. The metabolism of 4-substituted-N-ethyl-N-methylanilines. Some factors influencing α-C and N-oxidation. Xenobiotica 1983; 13: 513–520
  • Hibberd A. R., Gorrod J. W. Comparative N-oxidation of nicotine and cotinine by hepatic microsomes. Biological Oxidation of Nitrogen in Organic Molecules, J. W. Gorrod, L. A. Damani. Ellis Horwood, Chichester 1985; 246–253
  • Hlavica P., Kehl M. The role of cytochrome P-450 and mixed-function amine oxidase in the N-oxidation of N, N-dimethylaniline. Biochemical Journal 1977; 164: 487–496
  • Kloss M. W., Rosen G. M., Rauckman E. J. N-Demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase. Molecular Pharmacology 1983; 23: 482–485
  • McCoy G. D., Howard P. C., DeMarco G. J. Characterization of hamster liver nicotine metabolism. Biochemical Pharmacology 1986; 35: 2767–2773
  • Nagai Y., Irie A., Masuda Y., Oka M., Uno H. Synthesis of 2, 3, 4, 4a, 5, 9b-hexahydro-1H-pyrido[4,3-b]-indole derivatives and their central nervous system activities. Journal of Medicinal Chemistry 1979; 22: 677–683
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Poulsen L. L., Hyslop R. M., Ziegler D. M. S-Oxidation of thioureylenes catalyzed by a microsomal flavo-protein mixed-function oxidase. Biochemical Pharmacology 1974; 23: 3431–3440
  • Poulsen L. L., Ziegler D. M. The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studies. Journal of Biological Chemistry 1979; 254: 6449–6455
  • Scheline R. R. Mammalian Metabolism of Plant Xenobiotics. Academic Press, New York 1978; 371–474
  • Ŝtefek M., Benescar; L., Koccar;iscar; P. Biotransformation of stobadine in vivo. Czechoslovak Physiology 1986; 35: 367
  • Ŝtefek M., Benescar; L. Gas chromatographic determination of stobadine, N-desmethylstobadine and stobadine N-oxide in rat liver microsomal incubations. Journal of Chromatography 1987; 415: 163–169
  • Ŝtefek M., Benescar; L., Jergelová M., Ŝccar asná, Ar V., Turi-Nagy L., Koccar;iscar; P. Biotransformation of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, in rat liver microsomes. Xenobiotica 1987; 17: 1067–1073
  • Ŝtolc S., Bauer V., Benescar; L., Tich M. Stobadine, das Heilmittel besonders mit antiarrythmischer und subsidiärer Wirkung bei der Hypoxie des Myokard, sowie ein Verfaren zu ihrer Herstellung. Swiss Patent, 651754, 1985
  • Tynes R. E., Hodgson E. Catalytic activity and substrate specificity of the flavin-containing mono-oxygenase in microsomal systems: characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit and rat. Archives of Biochemistry and Biophysics 1985; 240: 77–93
  • Ziegler D. M., Mitchell C. H. Properties of a mixed-function amine oxidase isolated from pig liver microsomes. Archives of Biochemistry and Biophysics 1972; 150: 116–125
  • Ziegler D. M. Microsomal flavin-containing monooxygenase: oxygenation of nucleophilic nitrogen and sulphur compounds. Enzymatic Basis of Detoxication, W. B. Jakoby. Academic Press, New York 1980; Vol. 1: 201–227
  • Ziegler D. M. Molecular basis for N-oxygenation of sec-and tert-amines. Biological Oxidation of Nitrogen in Organic Molecules, J. W. Gorrod, L. A. Damani. Ellis Horwood, Chichester 1985; 43–52

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.