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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 2
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Original Article

Metabolic fate of strychnine in rats

K. Oguri Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan
,
Y. Tanimoto Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan
,
M. Mishima Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan
&
H. Yoshimura Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan
Pages 171-178 | Received 28 Mar 1988, Accepted 05 Oct 1988, Published online: 30 Sep 2009

References

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  • Kogure A., Kotake M. Studies on the chemical constitution of strychnine. XIII. The oxidation of strychnine with osmium tetroxide. Journal of the Institute of Polytechnics, Osaka City University, Ser.C: Chemistry 1951; 2: 39–43
  • Mishima M., Tanimoto Y., Oguri K., Yoshimura H. Metabolism of strychnin in vitro. Drug Metabolism and Disposition 1985; 13: 716–721
  • Murray K. N., Chaykin S. The reduction of nicotinamide N-oxide by xanthine oxidase. Journal of Biological Chemistry 1966; 241: 3468–3473
  • Oesterlin M. Strychninstudien. II. Mitteil: Untersuchungen und Umstezungen mit Strychninoxid. Chemische Berichte 1943; 76: 224–229
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  • Scheuer P. J. 18-Oxostrychnine. Journal of the American Chemical Society 1960; 82: 193–197
  • Sugiura M., Iwasaki K., Kato R. Reduced nicotinamide adenine dinucleotide dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450. Biochemical Pharmacology 1977; 26: 489–495
  • Tsukamoto H., Oguri K., Watabe T., Yoshimura H. Metabolism of drugs XLI. The metabolic fate of strychnine in rabbit liver. Journal of Biochemistry (Tokyo) 1964; 55: 394–400

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