The fate of cimetidine sulphoxide in the guinea pig

References

• Barnard D., Fabian J. M., Koch H. P. Valence vibration frequencies and hydrogen bond formation of sulphoxide and sulphone groups (Absorption spectra and structure of organic sulphur compounds. Part V). Journal of the Chemical Society 1949; 2442–2454
   Web of Science ®Google Scholar
• Clarke E. G. C. Isolation and Identification of Drugs. London Pharmaceutical Press, London 1978; Vol. 2: 182
   Google Scholar
• Coleman R. Biochemistry of bile secretion. Biochemical Journal 1987; 244: 249–261
   PubMed Web of Science ®Google Scholar
• Cross S. A. M., Lee R. M., Pepper E. S., Taylor D. C. Distribution and metabolism of two types of histamine H2-receptor antagonists. Xenobiotica 1977; 7: 108–109
   Web of Science ®Google Scholar
• Cymerman J., Willis J. B. The infra-red spectra and chemical structure of some aromatic disulphides, disulphones, and thiolsulphonates. Journal of the Chemical Society 1951; 1332–1337
   Web of Science ®Google Scholar
• Dixon P. A. F., Okereke N. O., Ogundahunsi O. A. Influence of species and drug pretreatment on the metabolic oxidation of cimetidine and metiamide. Biochemical Pharmacology 1985; 34: 2028–2030
   PubMed Web of Science ®Google Scholar
• Durant G. J., Emmett J. C., Ganellin C. R., Miles P. D., Parsons M. E., Prain H. D., White G. R. Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, histamine. Journal of Medical Chemistry 1977; 20: 901–906
   PubMed Web of Science ®Google Scholar
• Griffiths R., Lee R. M., Taylor D. C. Kinetics of cimetidine in man and experimental animals. Cimetidineb Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists, W. L. Burland, M. A. Simkins. Excerpta Medica, Amsterdam 1977; 38–53
   Google Scholar
• Jonsson K. A., Eriksson S. E., Kagevi I., Norlander B., Bodemar G., Walan A. No detectable concentrations of oxmetidine but measurable concentrations of cimetidine in cerebrospinal fluid (CSF) during multiple dose treatment. British Journal of Clinical Pharmacology 1984; 17: 781–782
   PubMed Web of Science ®Google Scholar
• Lee R. M., Osborne P. M. High-pressure liquid chromatographic determination of cimetidine sulphoxide in human blood and urine. Journal of Chromatography 1978; 146: 354–360
   PubMed Web of Science ®Google Scholar
• Mc Pherson F. J., Lee R. M. Biliary excretion and metabolism of 14C-cimetidine following oral administration to male and female rats. Experientia 1977; 33: 1139–1140
   PubMedGoogle Scholar
• Mitchell S. C., Idle J. R., Smith R. L. The metabolism of cimetidine in man. Xenobiotica 1982a; 12: 283–292
   PubMed Web of Science ®Google Scholar
• Mitchell S. C., Idle J. R., Smith R. L. Reductive metabolism of cimetidine sulfoxide in man. Drug Metabolism and Disposition 1982b; 10: 289–290
   PubMed Web of Science ®Google Scholar
• Mitchell S. C., Ritchie J. C., Idle J. R., Smith R. L. Nature of the polar urinary metabolites of metiamide and cimetidine in man. Biochemical Society Transactions 1982c; 10: 123–124
   Google Scholar
• Oldham H. G., Chenery R. J. Oxidation of cimetidine and ranitidine by the flavin-containing mono-oxygenase in pig liver microsomes. Biological Oxidation of Nitrogen in Organic Molecules, J. W. Gorrod, L. A. Damani. Ellis Horwood Ltd., England 1985; 115–121
   Google Scholar
• Patterson M. S., Greene R. C. Measurement of low energy beta-emitters in aqueous solution by liquid scintillation counting of emulsions. Analytical Chemistry 1965; 37: 584–587
   PubMed Web of Science ®Google Scholar
• Peterson J. I., Wagner F., Siegel S., Nixon W. A system for convenient combustion preparation of tritiated biological samples for scintillation analysis. Analytical Biochemistry 1969; 31: 189–203
   PubMed Web of Science ®Google Scholar
• Randolph W. C., Osborne V. L., Intoccia A. P. Cimetidine sulfoxide: Whole blood levels in normal human subjects and patients with varying degrees of renal failure. Pharmacologist 1980; 22: 278, Abstract 649
   Google Scholar
• Santaniello E., Manzocchi A., Farachi C. Tetrabutylammonium periodate: a selective and versatile oxidant for organic substrates. Synthesis 1980; 563–565
   Web of Science ®Google Scholar
• Scheline R. R. Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents. Journal of Pharmacy and Pharmacology 1966; 18: 664–669
   PubMed Web of Science ®Google Scholar
• Schultz M., Schmoldt A. On the sulfoxidation of cimetidine and etintidine by rat and human liver microsomes. 7th International Symposium on Microsomes and Drug Oxidations, Australia, Adelaide, 1987, Abstract
   Google Scholar
• Smith R. L. The Excretory Function of Bile. The Elimination of Drugs and Toxic Substances in Bile. Chapman and Hall, London 1973; 16–34
   Google Scholar
• Somogyi A., Gugler R. Clinical pharmacokinetics of cimetidine. Clinical Pharmacokinetics 1983; 8: 463–495
   PubMed Web of Science ®Google Scholar
• Taylor D. C., Cresswell P. R. The metabolism of cimetidine in the rat, dog and man. Biochemical Society Transactions 1975; 3: 884–885
   Web of Science ®Google Scholar
• Taylor D. C., Cresswell P. R., Bartlett D. C. The metabolism and elimination of cimetidine, a histamine H2-receptor antagonist, in the rat, dog, and man. Drug Metabolism and Disposition 1978; 6: 21–30
   PubMed Web of Science ®Google Scholar
• Totte J., Scharpe S., Verkerk R., Neels H., Vanhaeverbeek M., Smitz S., Rousseau J. J. Neurological dysfunction associated with abnormal levels of cimetidine metabolite. Lancet 1981; 1: 1047
   PubMed Web of Science ®Google Scholar
• Waring R. H., Wood P. B. Variation of cimetidine sulphoxidation in the developing guinea pig. Biochemical Society Transactions 1982; 10: 517–518
   Google Scholar
• Waring R. H., Mitchell S. C., Blundell R., Smith R. L. Novel aspects of the metabolism of cimetidine in the guinea pig. Biochemical Society Transactions 1986; 14: 98–99
   Web of Science ®Google Scholar
• Zbaida S., Silman-Greenspan J., Yosselson-Superstine S., Merin E. In vitro studies on the metabolism of cimetidine by rat liver microsomes—identification of a new N-desmethylcimetidine metabolite. Biopharmaceutics and Drug Disposition 1984; 5: 415–419
   PubMed Web of Science ®Google Scholar
• Ziemniak J. A., Chiarmonte D. A., Schentag J. J. Liquid-chromatographic determination of cimetidine, its known metabolites and creatinine in serum and urine. Clinical Chemistry 1981; 27: 272–275
   PubMed Web of Science ®Google Scholar