Zonal Distribution of Paracetamol Glucuronidation in the Isolated Perfused Rat Liver

References

• Araya H., Mizuma T., Hoie T., Hayashi M., Awazu S. Heterogenous distribution of the conjugation activity of acetaminophen and p‐nitrophenol in isolated rat liver cells. Journal of Pharmacobio‐Dynamics 1986; 9: 218–222
   PubMedGoogle Scholar
• Baron J., Redick J. A., Guengerich F. P. Immunohistochemical localization of cytochrome P‐450 in rat liver. Life Sciences 1978; 23: 2627–2632
   PubMed Web of Science ®Google Scholar
• Belinsky S. A., Matsumura T., Kauffman F. C., Thurman R. G. Rates of allyl alcohol metabolism in periportal and pericentral regions of the liver lobule. Molecular Pharmacology 1984; 25: 158–164
   PubMed Web of Science ®Google Scholar
• Conway J. G., Kauffman F. C., Ji S., Thurman R. G. Rates of sulphation and glucuronidation of 7‐hydroxycoumarin in periportal and pericentral regions of the liver lobule. Molecular Pharmacology 1982; 22: 509–516
   PubMed Web of Science ®Google Scholar
• Conway J. G., Kauffman F. C., Tsukada T., Thurman R. G. Glucuronidation of 7‐hydroxycoumarin in periportal and pericentral regions of the liver lobule. Molecular Pharmacology 1984; 25: 487–493
   PubMed Web of Science ®Google Scholar
• Dawson J. R., Weitering J. G., Mulder G. J., Stillwell R. N., Pang K. S. Alterations of transit time and directions of flow to probe the heterogenous distribution of conjugating activities for harmol in the perfused rat liver preparation. Journal of Pharmacology and Experimental Therapeutics 1985; 234: 691–697
   PubMedGoogle Scholar
• Desmond P. V., James R., Schenker S., Gerkens J. F., Branch R. A. Preservation of glucuronidation in carbon tetrachloride‐induced acute liver injury in the rat. Biochemical Pharmacology 1981; 30: 993–999
   PubMed Web of Science ®Google Scholar
• Evans G. H., Wilkinson G. R., Shand D. G. The disposition of propranolol. IV. A dominant role for tissue uptake in the dose‐dependent extraction of proporanolol by the perfused rat liver. Journal of Pharmacology and Experimental Therapeutics 1973; 186: 447
   PubMed Web of Science ®Google Scholar
• Fazz S., Cherry W. F., Dawson J. R., Milder G. J., Pang K. W. Inhibition of paracetamol sulphation by 2,6‐dichloro‐4‐nitrophenol in the perfused rat liver preparation: Lack of a compensatory increase of glucuronidation. Drug Metabolism and Disposition 1984; 12: 323–329
   PubMed Web of Science ®Google Scholar
• Green M. D., Fischer L. J. Age and sex‐related differences in acetaminophen metabolism in the rat. Life Sciences 1981; 29: 2421–2428
   PubMed Web of Science ®Google Scholar
• Gregus Z., Watkins J. B., Thompson T. N., Klaassen C. C. Resistance of some phase II biotransformation pathways to hepatotoxins. Journal of Pharmacology and Experimental Therapeutics 1982; 22: 471–479
   Google Scholar
• Gumucio J. J., DeMason J. J., Miller D. L., Krazoski S. O., Keener M. Induction of cytochrome P‐450 in a selective subpopulation of hepatocytes. American Journal of Physiology 1978; 234: C102–109
   Google Scholar
• Hjelle J. J., Klaassen C. D. Glucuronidation and biliary excretion of acetaminophen in rats. Journal of Pharmacology and Experimental Therapeutics 1984; 228: 407–413
   PubMed Web of Science ®Google Scholar
• Hjelle J. J., Hazelton G. A., Klaassen C. D. acetaminophen decreases adenosine 3′‐phosphate 5′‐phosphorsulphate and uridine diphosphoglucuronic acid in rat liver. Drug Metabolism and Disposition 1985; 13: 35–41
   PubMed Web of Science ®Google Scholar
• Howell S. R., Hazelton G. A., Klaassen C. D. Depletion of hepatic UDP‐glucuronic acid by drugs that are glucuronidated. Journal of Pharmacology and Experimental Therapeutics 1986; 236: 610–614
   PubMed Web of Science ®Google Scholar
• Howie D., Adriaenssens P. I., Prescott L. F. Paracetamol metabolism following overdosage: Application of high performance liquid chromatography. Journal of Pharmacology 1977; 29: 235–237
   Google Scholar
• James R., Desmond P., Kupfer A., Schenker S., Branch R. A. The differential localization of various drug metabolizing systems within the rat liver lobule as determined by the hepatotoxins allyl alcohol, carbon tetrachloride, and brombenene. Journal of Pharmacology and Experimental Therapeutics 1981; 217: 127–132
   PubMed Web of Science ®Google Scholar
• Jollow D. J., Mitchell J. R., Potter W. Z., Davis D. C., Gillette J. R., Brodie B. B. Acetaminophen‐induced hepatic necrosis. II. Role of covalent binding in vivo. Journal of Pharmacology and Experimental Therapeutics 1973; 187: 195–202
   PubMed Web of Science ®Google Scholar
• Jollow D. J., Roberts S., Price V., Smith C. Biochemical basis for dose response relationships in reactive metabolite toxicity. Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, R. Snyder, D. V. Parke, J. J. Kocsis, G. Gibson, D. J. Jollow. Plenum Press, New York 1982; 99
   Google Scholar
• Koster H., Halsema I., Scholtens E., Pang K. S., Mulder G. J. Kinetics of sulphation and glucuronidation in the perfused rat liver preparation. Biochemical Pharmacology 1982; 31: 3023–3028
   PubMed Web of Science ®Google Scholar
• Lowry O., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Mitchell M. C., Hanew T., Meredith C. G., Schenker S. Effects of oral contraceptive steroids on acetaminophen metabolism and elimination. Clinical Pharmacology and Therapeutics 1983; 34: 48–53
   PubMed Web of Science ®Google Scholar
• Mitchell M. C., Schenker S., Speeg K. V., Jr. Selective inhibition and acetaminophen oxidation and toxicity by cimetidine and other histamine H2‐receptor antagonists in vivo and in vitro in the rat and in man. Journal of Clinical Investigation 1984; 73: 383–391
   PubMed Web of Science ®Google Scholar
• Mouelhi M. E., Kauffman F. C. Sublobular distribution of transferases and hydroxylases associated with glucuronide, sulfate, and glutathione conjugation in human liver. Hepatology 1986; 6: 450–456
   PubMed Web of Science ®Google Scholar
• Mulder G. J., Weitering J. G., Browser S., Scholterns E. Pharmacokinetics of glucuronidation in the rat in vivo and in intact perfused organs. Glucuronidation of 4‐methylumbeliferone and harmol. Advances in Glucuronide Conjugation, S. Matern, K. W. Bock, W. Gerok. MTP Press, Hingham, Massachusetts 1984; 21–30
   Google Scholar
• Pang K. S., Terrell J. A. Retrograde perfusion to probe the heterogenous distribution of hepatic drug metabolizing enzymes in rats. Journal of Pharmacology and Experimental Therapeutics 1981; 216: 339–346
   PubMed Web of Science ®Google Scholar
• Pang K. S., Koster H., Halsema I. M. C., Scholtens E., Mulder G. J. Aberrant pharmacokinetics of harmol in the perfused rat liver preparation: sulphate and glucuronide conjugations. Journal of Pharmacology and Experimental Therapeutics 1981; 219: 134–140
   PubMed Web of Science ®Google Scholar
• Pang K. S., Koster H., Halsema I. M. C., Scholtens E., Mulder G. J., Stillwell R. N. Normal and retorgrade perfusion to probe the zonal distribution of sulphation and glucuronidation activities of harmol in the perfused rat liver preparation. Journal of Pharmacology and Experimental Therapeutics 1983; 224: 647–653
   PubMed Web of Science ®Google Scholar
• Price V. F., Jollow D. J. Role of UDPGA flux in paracetamol clearance and hepatotoxicity. Xenobiotica 1984; 14: 553–559
   PubMed Web of Science ®Google Scholar
• Reinke L. A., Belinsky S. A., Evans R. K., Kauffman F. C., Thurman R. G. Conjugation of p‐nitrophenol in the perfused rat liver: the effect of substrate concentration and carbohydrate reserves. Journal of Pharmacology and Experimental Therapeutics 1981; 217: 863–870
   PubMed Web of Science ®Google Scholar
• Watari N., Iwai M., Kaneniwa N. Pharmacokinetics study of the fate of acetaminophen and its conjugates in rats. Journal of Pharmacokinetics and Biopharmaceutics 1983; 211: 256–272
   Google Scholar