Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 4
92
Views
78
CrossRef citations to date
0
Altmetric
Research Article

Comparison of Caffeine Metabolism by Slices, Microsomes and Hepatocyte Cultures from Adult Human Liver

, , , , &
Pages 401-417 | Received 02 Jun 1988, Accepted 24 Nov 1988, Published online: 22 Sep 2008

References

  • Aldridge A., Aranda J. V., Neims A. H. Caffeine metabolism in the newborn. Clinical Pharmacology and Therapeutics 1979; 25: 447–453
  • Arnaud M. J. Identification, kinetic and quantitative study of ‘2‐14C’ and ‘1‐Me‐14C’ caffeine metabolites in rat's urine by chromatographic separations. Biochemical Medicine 1976; 16: 67–76
  • Arnaud M. J., Welsch C. Comparison of caffeine metabolism by perfused liver and isolated microsomes. Microsomes, Drug Oxidations and Chemical Carcinogenesis, M. J. Coon, A. H. Conney, R. W. Estabrook, H. V. Gelboin, J. R. Gillette, P. J. O'Brien. Academic Press, New York 1980a; 813–816
  • Arnaud M. J., Welsch C. Caffeine metabolism in human subjects. ASIC, 9 ème colloque, Londres 1980; 385–396
  • Arnaud M. J. Products of metabolism of caffeine. Caffeine: Perspectives From Recent Research, P. B. Dews. Springer‐Verlag, Berlin 1984; 3–38
  • Benford D. Intact cells as a biological model for metabolism. Drug Metabolism‐From Molecules to Man, D. Benford, J. W. Bridges, G. G. Gibson. Taylor & Francis, London 1987; 392–400
  • Berthou F., Alix D., Riché C., Picart D., Dréano Y., Gouédard H. Utilisation de la caféine dans le traitement des apnées chez le prématuré. Developmental Pharmacology and Therapeutics 1982; 4: 187–196
  • Berthou F., Ratanasavanh D., Riché C., Guillouzo A. Caffeine metabolism by human and rat hepatocytes in primary culture. Liver Cells and Drugs, A. Guillouzo. INSERM/John Libbey‐Eurotext, Paris 1988; Vol. 164: 287–292
  • Berthou F., Ratanasavanh D., Alix D., Carlhant D., Riché C., Guillouzo A. Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes. Biochemical Pharmacology 1988; 37: 3691–3700
  • Bonati M., Garattini S. Interspecies comparison of caffeine disposition. Caffeine: Perspectives From‐Recent Research, P. B. Dews. Springer‐Verlag, Berlin 1984; 48–56
  • Boobis A. R., Broodie M. J., Kahn G. C., Flechter D. R., Saunders J. H., Davies D. S. Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens. British Journal of Clinical Pharmacology 1980; 9: 11–19
  • Boobis A. R., Davies D. S. Human cytochromes P‐450. Xenobiotica 1984; 14: 151–185
  • Burke M. D., Mayer R. T. Differential effects of phenobarbitone and 3‐methylcholanthrene induction of the hepatic microsomal metabolism and cytochrome P‐450 binding of phenoxazone and a homologous series of its n‐alkyl ethers (alkoxyresorufins). Chemical Biological Interactions 1983; 45: 243–258
  • Campbell M., Grant D., Inaba T., Kalow W. Biotransformation of caffeine, paraxanthine, theophylline and theobromine by polycyclic aromatic hydrocarbon‐inducible cytochrome(s) P‐450 in human liver microsomes. Drug Metabolism and Disposition 1987; 15: 237–249
  • Ferrero J. L., Neims A. H. Metabolism of caffeine by mouse liver microsomes. GSH or cytosol causes a shift in products from 1,3,7‐trimethylurate to a substituted diaminouracil. Life Sciences 1983; 33: 1173–1178
  • Gorodischer R., Yaari A., Margalith M., Warszawski D., Ben‐Zvi Z. Changes in theophylline metabolism during postnatal development in rat liver slices. Biochemical Pharmacology 1986; 35: 3077–3081
  • Grant D. M., Tang K. B., Kalow W. Variability in caffeine metabolism. Clinical Pharmacology and Therapeutics 1983; 33: 591–602
  • Grant D. M., Campbell M. E., Tang K. B., Kalow W. Biotransformation of caffeine by microsomes from human liver: kinetics and inhibitory studies. Biochemical Pharmacology 1987; 36: 1251–1260
  • Guguen‐Guillouzo C., Campion J. P., Brissot P., Glaise D., Launois B., Bourel M., Guillouzo A. High yield preparation of isolated adult human hepatocytes by enzymatic perfusion of the liver. Cell Biology International Reports 1982; 6: 625–628
  • Ioannindes C., Parke D. V. The cytochrome P‐448‐A unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochemical Pharmacology 1987; 36: 4197–4207
  • Jung B., Graf H., Ullrich V. A new monooxygenase product from 7‐ethoxycoumarin and its relation to the O‐dealkylation reaction. Biological Chemistry Hoppe‐Seyler 1985; 255: 23–31
  • Kahn G. C., Boobis A. R., Murray S., Brodie M. J., Davies D. S. Assay and characterisation of debrisoquine 4‐hydroxylase activity of microsomal fractions of human liver. British Journal of Clinical Pharmacology 1982; 13: 637–645
  • Kalow W. Genetic variation in the human hepatic cytochrome P‐450 system. European Journal of Clinical Pharmacology 1987; 31: 633–641
  • Kronbach T., Mathys D., Gut J., Catin T., Meyer U. A. High performance liquid chromatography assays for bufuralol 1‐hydroxylase, debrisoquine 4‐hydroxylase and dextromethorphan O‐demethylase in microsomes and purified cytochrome P‐450 isozymes of human liver. Analytical Biochemistry 1987; 162: 24–32
  • Larrey D., Annouyal G., Tissel M., Letteron P., Berson A., Labbe G., Pessayre D. Polymorphism of dextromethorphan oxidation in a French population. British Journal of Clinical Pharmacology 1987; 24: 676–679
  • Lelo A., Miners O., Robson R., Birkett D. J. Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines. Clinical Pharmacology and Therapeutics 1986a; 39: 56–59
  • Lelo A., Miners R. A., Birkett D. J. Quantitative assessment of caffeine partial clearances in man. British Journal of Clinical Pharmacology 1986b; 22: 183–186
  • Lowry O. H., Rosebrough N. G., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Maurel P., Dalet‐Beluche I., Dalet C., Bonfils C., Boivers P., Bauret P., Michel H. Activités enzymatiques et dosage immunologique d'une forme de cytochrome P‐450 microsomale dans des biopsies hépatiques à l'aiguille. Hepatoxicity of Drugs, J. P. Fillastre. INSERM publ., Rouen 1986; 287–304
  • Muir K. T., Jonkman J. H. G., Tang D. S., Kunitani M., Riegelman S. Simultaneous determination of theophylline and its major metabolites in urine by reversed‐phase ion‐pair h.p.l.c. Journal of Chromatography 1980; 221: 85–95
  • Müller‐Enoch D., Greischel A. A direct h.p.l.c.‐method for measuring cytochrome P‐450 activities with scoparone as substrate. Liver Cells and Drugs, A. Guillouzo. INSERM/John Libbey Eurotext, Paris 1988; Vol. 164: 85–88
  • Omura T., Sato E. Carbon monooxide binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2379
  • Prough R. A., Burke M. D., Mayer R. T. Direct fluorimetric methods for measuring mixed‐function oxidases activities. Methods in Enzymology, S. Fleischer, L. Packer. Academic Press, New York 1978; Vol. 52: 372–377
  • Renner E., Wietholtz H., Huguenin P., Arnaud M. J., Preisig R. Caffeine: a model compound for measuring liver function. Hepatology 1984; 4: 38–48
  • Schmid B., Bircher M. D., Preisig R., Küpfer A. Polymorphic dextromethorphan metabolism: co‐segregation of oxidative O‐demethylation with debrisoquine hydroxylation. Clinical Pharmacology and Therapeutics 1985; 38: 618–624
  • Scott N. R., Chakraborty J., Marks V. Determination of the urinary metabolites of caffeine and theophylline by h.p.l.c. A comparative study of direct injection and an ion‐pair extraction procedure. Journal of Chromatography 1986; 375: 321–329
  • Tang‐Liu D. D., Riegelman S. An automated h.p.l.c. assay for simultaneous quantitation of methylated xanthines and uric acids in urine. Journal of Chromatography 1982; 20: 155–159
  • Tang‐Liu D. D., Williams R. L., Riegelman S. Disposition of caffeine and its metabolites in man. Journal of Pharmacology and Experimental Therapeutics 1983; 224: 180–185
  • Tauc M., Hermann M., Dansette P. M., Vandecastelle J. P. Enzymatic characterization of the polynuclear aromatic hydrocarbons activating rat‐liver preparations used in the mutagenicity test of Ames. Mutation Research 1984; 125: 123–133
  • Warszawski D., Ben‐Zvi Z., Gorodischer R. Caffeine metabolism in liver slices during postnatal development in the rat. Biochemical Pharmacology 1981; 30: 3145–3150
  • Wietholtz H., Voegelin M., Arnaud M. J., Bircher J., Preisig R. Assessment of the cytochrome P‐448 dependent liver enzyme system by a caffeine breath test. European Journal of Clinical Pharmacology 1981; 21: 53–59
  • Williams F. M., Mutch E., Woodhouse K. W., Lambert D., Rawlins M. D. Ethoxyresorufin deethylation by human liver microsomes. British Journal of Clinical Pharmacology 1986; 22: 263–268

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.