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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 5
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Research Article

The Measurement of D-Fenfluramine and Its Metabolite, D-Norfenfluramine in Plasma and Urine with an Application of the Method to Pharmacokinetic Studies

R. P. Richards Department of Metabolism and Pharmacokinetics, Servier Research and Development Ltd., Fulmer Hall, Fulmer, Slough, SL3 6HH, UK
,
B. H. Gordon Department of Metabolism and Pharmacokinetics, Servier Research and Development Ltd., Fulmer Hall, Fulmer, Slough, SL3 6HH, UK
,
R. M. J. Ings Department of Metabolism and Pharmacokinetics, Servier Research and Development Ltd., Fulmer Hall, Fulmer, Slough, SL3 6HH, UK
,
D. B. Campbell Department of Metabolism and Pharmacokinetics, Servier Research and Development Ltd., Fulmer Hall, Fulmer, Slough, SL3 6HH, UK
&
L. J. King Department of Biochemistry, University of Surrey, Guildford, Surrey, GU2 5XH, UK
Pages 547-553 | Received 15 Jan 1987, Published online: 22 Sep 2008

References

  • Beckett A. H., Brookes L. G. The absorption and urinary excretion in man of fenfluramine and its main metabolite. Journal of Pharmacy and Pharmacology 1967; 19: 42S–49S, Suppl.
  • Beckett A. H., Rowland M. Determination and identification of amphetamine in urine. Journal of Pharmacy and Pharmacology 1965; 17: 59
  • Bruce R. B., Maynard W. R. Fenfluramine metabolism. Journal of Pharmaceutical Sciences 1968; 57(7)1173–1176
  • Caccia S., Jori A. Gas liquid chromatographic determination of the optical isomers of fenfluramine and norfenfluramine in biological samples. Journal of Chromatography 1977; 144: 127–131
  • Campbell D. B. Gas chromatographic measurement of levels of fenfluramine and norfenfluramine in human plasma, red cells and urine following therapeutic doses. Journal of Chromatography 1970; 49: 442–447
  • Gibaldi M., Perrier D. Drugs and The Pharmaceutical Sciences. Marcel Dekker, New York 1975; Vol. 15: 433–444, Appendix C, Method of Residuals
  • Hawkins D. R., Midgley I. The synthesis of ‘14C’‐fenfluramine and ‘14C’‐780SE. Journal of Labelled Compounds 1974; 10: 663–670
  • Midha K. K., McGilveray I. J., Cooper J. K. A GLC‐ECD assay for simultaneous determination of fenfluramine and norfenfluramine in human plasma and urine. Canadian Journal of Pharmaceutical Sciences 1979; 14(1)18–21
  • Ramsey J., Campbell D. B. An ultra rapid method for the extraction of drugs from biological fluids. Journal of Chromatography 1971; 63: 303–308
  • Richards R. P. Ph.D. thesis, University of Surrey. 1985
  • Silverstone J. T., Smith G., Richards R. P. A comparative evaluation of dextro‐fenfluramine and d1 ‐fenfluramine on hunger, food intake, psychomotor function and side effects in normal human subjects. Body Weight Control, A. E. Bender, L. J. Brookes. Churchill Livingstone, Edinburgh 1987; 240–246

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