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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 8
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Research Article

Metabolism of a new radioprotector; S-acetyl-N-glycyl cysteamine. II. Main tissue metabolites in mice bearing EMT6 tumours

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Pages 833-842 | Received 03 Oct 1988, Accepted 10 Mar 1989, Published online: 22 Sep 2008

References

  • Brown P. E. Mechanism of action of aminothiols radioprotection. Nature 1967; 213: 363–364
  • Cavallini D., Demarco C., Scandurra R., Silvestro D., Graziani M. T. The enzymatic oxidation of cysteamine to hypotaurine. Journal of Biological Chemistry 1966; 241: 3189–3196
  • Fahey R. C., Newton G. L. The occurrence of low molecular weight thiols in biological systems. Function of Glutathione, Biochemical, Physiological and Toxicological Aspects, A. Larsson, et al. Raven Press, New York 1982
  • Fahey R. C., Newton G. L., Dorian R., Kosower E. M. Analysis of biological thiols: derivatization with monobromo-trimethylammoniobimane and characterization by electrophoresis and chromatography. Analytical Biochemistry 1980; 111: 357–365
  • Fahey R. C., Dorian R., Newton G. L. Determination of intracellular thiol levels using monobromobimane fluorescent labelling: applications involving radioprotective drugs. Radio-protectors and Anticarcinogens, O. F. Nygaard, M. G. Simic. Academic Press, New York 1983
  • Kosower E. M., Kosower N. S. Glutathione status of cells. International Review of Cytology 1978; 54: 106–109
  • Kosower E. M., Pazhenchevsky B., Hershkowitz E. 1,5-diazabicyclo ‘3–3–0’octadiene diones (9,10-dioxabimanes), Strongly fluorescent syn isomers. Journal of the American Chemical Society 1978; 100: 6516–6518
  • Lespinasse F., Oiry J., Fatome M., Ardouin P., Imbach J. L., Malaise E. P., Guichard M. Radioprotection of EMT6 tumour by a new class of radioprotectors based on a pseudopeptide cysteamine combination. Journal of Radiation Oncology, Biology, and Physics 1985; 11: 1035–1038
  • Madelmont J. C., Parry D., Moreau M. F., Godeneche D., Oiry J., Imbach J. L. Marquage par 14C du S-Acetyl, N-Glycylcysteamine (I102). Journal of Labelled Compounds 1986; 23: 569–575
  • Maurizis J. C., Godeneche D., Madelmont J. C., Moreau M. F., Oiry J., Imbach J. L., Veyre A. Metabolism of a new radioprotector, S-acetyl-N-glycyl cysteamine (I 102). I. Absorption, distribution and excretion metabolites in mice bearing EMT6 tumours. Xenobiotica 1988, (In press)
  • Oiry J., Imbach J. L. Nouveaux agents radioprotecteurs ayant une structure aminothioalkyle et procédé pour leur préparation. 1983, brevet français no. 83–10318
  • Yuhas J. M. Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-amino-propylamino) ethylphosphorothioic acid. Cancer Research 1980; 40: 1519–1524
  • Ziegler D. M., Mitchell C. H. Microsomal oxidase, IV: Properties of a mixed-function amine oxidase isolated from pig liver microsomes. Archives of Biochemistry and Biophysics 1972; 15: 116–125

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