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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 9
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Research Article

Inhibition of lignocaine metabolism by β-adrenoceptor antagonists in rat and human liver microsomes

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Pages 929-944 | Received 24 May 1988, Accepted 28 Apr 1989, Published online: 22 Sep 2008

References

  • Baker J. K., Rauls D. O., Borne F. R. Correlation of biological activity and HPLC retention index for a series of propranolol, barbiturate and anthranilic acid analogues. Journal of Medicinal Chemistry 1979; 22: 1301
  • Bax N. D. S., Lennard M. S., Tucker G. T. Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists. British Journal of Clinical Pharmacology 1983; 12: 779–784
  • Bax N. D. S., Jones R. W., Lennard M. S., Tucker G. T., Woods H. F. Penbutolol and propanolol: a comparison of their effects on antipyrine clearance in man. British Journal of Clinical Pharmacology 1985; 19: 593–596
  • Conrad K. A., Nyman D. W., Tuscon M. S. Lidocaine elimination: effects of metoprolol and propranolol. Clinical Pharmacology and Therapeutics 1980; 33: 133–138
  • Deacon C. S., Lennard M. S., Bax N. D. S., Woods H. F., Tucker G. T. Inhibition of oxidative drug metabolism by beta-adrenoceptor antagonists is related to their lipid solubility. British Journal of Clinical Pharmacology 1981; 12: 429–430
  • Facino R. M., Lanzani R. Interaction of a series of beta-adrenergic blocking drugs with rat hepatic microsomal monooxygenase. Pharmacological Research Communications 1979; 11: 433–445
  • Hermansson J., Glaumann H., Karlen B., von Bahr C. Metabolism of lidocaine in human liver in vitro. Acta Pharmacologica et Toxicologica 1980; 47: 49–52
  • Hinderling P. H., Schmidlin O., Seydel J. K. Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man. Journal of Pharmacokinetics and Biopharmaceutics 1984; 12: 263–287
  • Levin W., Kuntzman R. Biphasic decrease of radioactive hemoprotein from liver microsomal co-binding particles. Molecular Pharmacology 1969; 5: 499–506
  • Lowry O. H., Rosenbraugh N. H., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Mazel P. Experiments illustrating drug metabolism in vitro. Fundamentals of Drug Metabolism and Disposition, B. N. LaDu, H. G. Mandel, E. L. Way. Williams & Wilkins, Baltimore 1972; 546–582
  • Nakagawa Y., Hiraga K., Suga T. Biological fate of butyrated hydroxytoluen (BHT): binding in vitro of BHT to liver microsomes. Chemical and Pharmaceutical Bulletin 1979; 27: 480–485
  • Ochs H. R., Skanderra D., Abernathy D. R., Greenblatt D. J. Effect of penbutolol on lidocaine kinetics. Arzneimiitel Forschung 1983; 33: 1680–1681
  • Ochs H. R., Hajdu P., Greenblatt D. J. Pharmacokinetics and dynamics of penbutolol in humans: evidence for pathway-specific stereoselective clearance. Klinische Wochenschrift 1986; 64: 636–641
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification and properties. Journal of Biological Chemistry 1964; 239: 2379–2385
  • Pritchard J. F., Schneck D. W., Hayes A. H. The inhibition of rat hepatic microsomal propranolol by a covalently bound reactive metabolite. Research Communications in Chemical Pathology and Pharmacology 1980; 27: 211–221
  • Schneck D. W., Pritchard J. F. The inhibitory effect of propranolol and pretreatment on its own metabolism in the rat. Journal of Pharmacology and Experimental Therapeutics 1981; 218: 575–581
  • Shaw L., Lennard M. S., Tucker G. T., Bax N. D. S., Woods H. F. Irreversible binding and metabolism of propranolol in human liver microscomes—relationship to polymorphic oxidation. Biochemical Pharmacology 1987; 35: 2283–2288
  • Smith A. J., Tucker G. T. Kinetics and biotransformation of adrenergic inhibitors. Adrenergic Activators and Inhibitors, Part II, L. Szekeres. Springer-Verlag, Berlin 1981; 417–501
  • Street J. A., Gonda I., Parkinson H., Hemsworth B. A. Lung accumulation of some beta-adrenoceptor antagonists. Journal of Pharmacy and Pharmacology 1978; 30S: 59P
  • Suzuki T., Fujita S., Kawai R. Precursor-metabolite interaction in the metabolism of lidocaine. Journal of Pharmaceutical Sciences 1984; 73: 136–138
  • Taylor D. C., Pownall R., Burke W. The absorption of beta-adrenoceptor antagonists in rat in situ small intestine; the effect of lipophilicity. Journal of Pharmacy and Pharmacology 1985; 37: 280–283
  • Topham J. C. Relationship between difference spectra and metabolism. Biochemical Pharmacology 1970; 19: 1695–1701
  • Tucker G. T., Bax N. D. S., Lennard M. S., Crewe H. K., Woods H. F. Lack of effect of atenolol on antipyrine clearance. British Journal of Clinical Pharmacology 1982; 14: 743–744
  • Tucker G. T., Bax N. D. S., Lennard M. S., Al-Asady S. A. H., Bharaj H. S., Woods H. F. Effect of beta-adrenoceptor antagonists on the pharmacokinetics of lignocaine. British Journal of Clinical Pharmacology 1984; 17: 21S–28S
  • von Bahr C., Hedlund I., Karlen B., Backstrom D., Grasdalen H. Evidence for two catalytically different binding sites of liver microsomal cytochrome P-450: importance of species and sex differences in oxidation pattern of lidocaine. Acta Pharmacologica et Toxicologica 1977; 4: 39–48
  • Woods P. B., Robinson M. L. An investigation of the comparative liposolubilities of beta-adrenoceptor blocking agents. Journal of Pharmacy and Pharmacology 1981; 33: 172–173
  • Ylitalo P., Linden I.-B., Pentila A., Vapaatalo H. Distribution of beta-adrenoceptor blocking drugs into cerebrospinal fluid in rats. Acta Pharmacologica et Toxicologica 1986; 58: 84–87

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