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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
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Research Article

Metabolism of organonitriles to cyanide by rat nasal tissue enzymes

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Pages 1201-1205 | Received 23 Aug 1988, Accepted 24 Apr 1989, Published online: 22 Sep 2008

References

  • Baron J., Burke J. P., Guengerich F. P., Jakoby W. B., Voigt J. M. Sites for xenobiotic activation and detoxication with the respiratory tract: implications for chemically induced toxicity. Toxicology and Applied Pharmacology 1988; 93: 493–505
  • Contessa A. R., Santi R. Liberation of cyanide from succino-nitrile. Biochemical Pharmacology 1973; 22: 827–832
  • Dahl A. R. The cyanide metabolizing enzyme rhodanese in rat nasal respiratory and olfactory mucosa. Toxicology Letters 1989; 45: 199–205
  • Dahl A. R., Bechtold W. E. Deposition and clearance of water-reactive vapor. methylphosphonic difluoride (difluoro), inhaled by rats. Toxicology and Applied Pharmacology 1985; 81: 58–66
  • Dahl A. R., Bond J. A., Petridou-Fischer J., Sabourin P. J., Whaley S. J. Effects of the respiratory tract on inhaled materials. Toxicology and Applied Pharmacology 1988; 93: 484–492
  • Enviro Control, Inc. Final Report: Economic Impact Assessment for Acrylonitrile. Occupational Safety and Health Administration, U.S. Department of Labor, Washington, DC 1978, Contract Report J-9-F-6–0229
  • Guengerich F. P. Microsomal enzymes involved in toxicology—analysis and separation. Principles and Methods of Toxicology, A. W. Hayes. Raven Press, New York 1982; 613
  • Hadley W. M., Dahl A. R. Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes. Toxicology Letters 1982; 10: 417–422
  • Hadley W. M., Dahl A. R. Cytochrome P-450-dependent monooxygenase activity in nasal membranes of six species. Drug Metabolism and Disposition 1983; 11: 275–276
  • Pettigrew A. R., Fell G. S. Simplified colorimetric determination of thiocyanate in biological fluids, and its application to investigation of the toxic amblyopias. Clinical Chemistry 1972; 18: 996–1000
  • Sabourin P. J., Tynes R. E., Philpot R. M., Winquist S., Dahl A. R. Distribution of microsomal monooxygenases in the rabbit respiratory tract. Drug Metabolism and Disposition 1988; 16: 557–562
  • Willhite C. C., Smith R. P. The role of cyanide liberation in the acute toxicity of aliphatic nitriles. Toxicology and Applied Pharmacology 1981; 59: 589–602

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