Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
Submit an article Journal homepage
56
Views
52
CrossRef citations to date
0
Altmetric
Research Article

Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans

A. N. Kotake Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
,
S. K. Kuwahara Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
,
E. Burton Department of Drug Metabolism, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, 60077, USA
,
C. E. McCoy Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
&
L. I. Goldberg Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
Pages 1247-1254 | Received 24 Nov 1988, Accepted 04 May 1989, Published online: 22 Sep 2008

References

  • Bianchi G., Fiocchi R., Tavani A., Manara L. Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity. Life Sciences 1982; 30: 1875–1883
  • Brown D. R., Goldberg L. I. The use of quaternary narcotic antagonists in opiate research. Neuropharmacology 1985; 24: 181–191
  • Brown D. R., Robertson M. J., Goldberg L. I. Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives. Neuropharmacology 1983; 22: 317–321
  • Jonkman J. H. G., van Vork L. E., Wijsbeek J., Bolhuis-de Vries A. S., de Zeeuw R. A., Orie N. G. M., Cox H. L. M. First-pass effect after rectal administration of thizinamium methylsulfate. Journal of Pharmaceutical Sciences 1979; 68: 69–72
  • Kato R. Characteristics and differences in the hepatic mixed function oxidase of different species. Pharmacology and Therapeutics 1979; 6: 41–98
  • Maduagwu E. N. Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat. Xenobiotica 1985; 15: 1061–1068
  • Manara L., Bianchetti A. The central and peripheral influences of opioids on gastrointestinal propulsion. Annual Review of Pharmacology and Toxicology 1985; 25: 249–273
  • Metzler C. M., Elfring G. L., McEven A. J. A User's Manual for NONLIN and Associated Programs: Research biostatistics. Upjohn Company, Kalamazoo, MI 1974
  • Misra A. L., Pontani R. B., Vadlamani N. L. Intravenous kinetics and metabolism of ‘15,16-3H’naltrexonium methyliodide in the rat. Journal of Pharmacy and Pharmacology 1987; 39: 225–227
  • Neff C., Meijer D. K. F. Structure-pharmacokinetic relationship of quaternary ammonium compounds. Archives of Pharmacology 1984; 328: 111–118
  • Neff C., Oosting R., Meijer D. F. K. Structure-pharmacokinetic relationship of quaternary compounds. Archives of Pharmacology 1984; 328: 103–110
  • Ramabadran K. Effects of N-methylnaloxone and N-methylnaltrexone on nociception and precipitated abstinence of mice. Life Sciences 1982; 31: 1253–1256
  • Russell J., Bass P., Goldberg L. I., Schuster C. R., Merz H. Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists. European Journal of Pharmacology 1982; 78: 255–261
  • Schoeller D. A., Baker A. L., Monroe P. S., Krager P. S., Schneider J. F. Comparison of different methods of expressing results of the aminopyrine breath test. Hepatology 1982; 2: 455–462
  • Valentino R. J., Katz J. L., Medzihradsky F., Woods J. H. Receptor binding, antagonist, and withdrawal precipitating properties of opiate antagonists. Life Sciences 1983; 32: 2887–2896

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.