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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
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Research Article

Metabolism of dihydroergotamine by a cytochrome P-450 similar to that involved in the metabolism of macrolide antibiotics

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Pages 1285-1295 | Received 13 Dec 1988, Accepted 04 May 1989, Published online: 22 Sep 2008

References

  • Aellig W. Investigation of the venoconstriction effect of 8′hydroxy-dihydroergotamine. The main metabolite of dihydroergotamine. European Journal of Clinical Pharmacology 1984; 26: 239–242
  • Black S. D., Coon M. J. Comparative structures of P-450 cytochromes. Cytochrome P-450, P. R. Ortiz de Montellano. Plenum, New York 1986; 161–216
  • Bonfils C., Dalet-Beluche I., Maurel P. Induction by triacetyloleandomycin and partial purification of a LM3 form of cytochrome P-450 from rabbit liver microsomes. Biochemical and Biophysical Research Communications 1982; 104: 1011–1017
  • Collignon F., Pradelles P. Highly sensitive and specific radioimmunoassays for dihydroergotoxine components in plasma. European Journal of Nuclear Medicine 1984; 9: 23–27
  • Delaforge M., Jaouen M., Mansuy D. Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite complexes: a structure-activity relationship. Biochemical Pharmacology 1983; 32: 2309–2318
  • Delaforge M., Jaouen M., Mansuy D. The cytochrome P-450 metabolite complex derived from troleandomycin: properties in vitro and stability in vivo. Chemico-Biological Interaction 1984; 51: 371–376
  • Dumont M., Decouet G., Lebigot J. F., Erlinger S. Mechanism of uptake of dihydroergotamine by isolated rat hepatocytes: effect of troleandomycin. Biochemical Pharmacology 1985; 234: 239–243
  • Gonzalez F. J., Nebert D. W., Hardwich J. P., Kasper C. B. Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. Journal of Biological Chemistry 1985; 260: 7435–7441
  • Grognet J. M., Doignon J. L., Riviére R., Brunengo J. F., Delaforge M., Istin M. Two immunoassays for studying pharmacokinetics and metabolism of dihydroergotamine. Proceedings of the Third European Congress of Biopharmaceutics and Pharmacokinetics. Freiburg 1987; Vol. 1: 293–300
  • Guengerich F. P., Dannan G. A., Wright S. J., Martin M. T., Kaminsky L. S. Purification and characterization of liver microsomal cytochromes P-450. Electrophoretic, spectral, catalytic and immunochemical properties and inductibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone. Biochemistry 1982; 21: 6019–6030
  • Halpert J. R. Multiplicity of steroid-inducible cytochrome P-450 in rat liver microsomes. Archives of Biochemistry and Biophysics 1988; 263: 59–68
  • Hostetler K. A., Wrighton S. A., Kremers P., Guzelian P. S. Immunochemical evidence for multiple steroid-inducible hepatic cytochrome P-450 in the rat. Biochemical Journal 1987; 245: 27–33
  • Kremers P., Beaune P., Cresteil T., DeGraeve J., Columelli S., Leroux J. P., Gielen J. Cytochrome P-450 monooxygenase activities in human and rat liver microsomes. European Journal of Biochemistry 1981; 118: 599–606
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Ludden T. M. Pharmacokinetic interactions of the macrolide antibiotics. Clinical Pharmacokinetics 1985; 10: 63–79
  • Mansuy D., Delaforge M., Leprovost E., Flinois J. P., Columelli S., Beaune P. Induction of cytochrome P-450 in rat liver microsomes by the antibiotic troleandomycin: partial purification and properties of cytochrome P-450-troleandomycin metabolite complex. Biochemical and Biophysical Research Communications 1981; 103: 1201–1208
  • Martinet M., Kiechel J. R. Interaction of dihydroergotamine and triacetyloleandomycin in the minipig. European Journal of Drug Metabolism and Pharmacokinetics 1983; 8: 261–267
  • Maurer G., Frick W. Elucidation of the structure and receptor binding studies of the major primary metabolite of dihydroergotamine in man. European Journal of Clinical Pharmacology 1984; 26: 463–470
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2379
  • Pershing L. K., Franklin M. R. Cytochrome P-450 metabolic intermediate complex formation and induction by macrolide antibiotics; a new class of agents. Xenobiotica 1982; 12: 687–699
  • Pessayre D., Descatoire V., Konstantinova-Mitcheva M., Wandscheer J. C., Cobert B., Level R., Benhamou J. P., Jaouen M., Mansuy D. Self-induction by triacety-loleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450. Biochemical Pharmacology 1981a; 30: 553–558
  • Pessayre D., Konstantinova-Mitcheva M., Descatoire V., Cobert B., Wandscheer J. C., Level R., Feldman G., Mansuy D., Benhamou J. P. Hypoactivity of cytochrome P-450 after triacetyloleandomycin administration. Biochemical Pharmacology 1981b; 30: 559–564
  • Pessayre D., Larrey D., Vitaux J., Breil P., Belghiti J., Benhamou J. P. Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in human. Biochemical Pharmacology 1982; 31: 1699–1704
  • Sartori E., Delaforge M., Mansuy D., Beaune P. Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16αpregnenolone carbonitrile. Biochemical and Biophysical Research Communications 1985; 128: 1434–1439
  • Schran H. F., Schwarz H. J., Talbot K. C., Loeffle L. J. Specific radioimmunoassay of ergot peptid alkaloids in plasma. Clinical Chemistry 1979; 25: 1928–1933
  • Wang P. P., Beaune P., Kaminski L. S., Dannan G. A., Kadlubar F. F., Larrey D., Guengerich F. P. Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes. Biochemistry 1983; 22: 5375–5383
  • Watkins P. B., Wrighton S. A., Maurel P., Schuetz E. G., Mendez-Picon G., Parker G. A., Guzelian P. S. Identification of an inducible form of cytochrome P-450 in human liver. Proceedings of the National Academy of Sciences, USA 1985; 82: 6310–6314
  • Wrighton S. A., Maurel P., Schuetz E. G., Watkins P. B., Young B., Guzelian P. S. Identification of the cytochrome P-450. induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450. Biochemistry 1985; 24: 2171–2178

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