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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
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Research Article

Quaternary ammonium glucuronide of croconazole in rabbits

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Pages 1327-1336 | Received 10 Mar 1989, Accepted 05 May 1989, Published online: 22 Sep 2008

References

  • Aue W. P., Bartholdi E., Ernst R. R. Two-dimensional spectroscopy. Application to nuclear magnetic resonance. Journal of Chemical Physics 1976; 64: 2229–2246
  • Bothner-By A. A., Stephens R. L., Lee J., Warren C. D., Jeanloz R. W. Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame. Journal of the American Chemical Society 1984; 106: 811–813
  • Caesar F., Overberger C. G. Nuclear magnetic resonance of 1-methylimidazole methiodide. Journal of Organic Chemistry 1968; 33: 2971
  • Chaudhuri N. K., Servando O. A., Manniello M. J., Luders R. C., Chao D. K., Bartlett M. F. Metabolism of tripelennamine in man. Drug Metabolism and Disposition 1976; 4: 372–378
  • Dahl-Puustinen M., Bertilsson L. Formation of a quaternary N-glucuronide of amitriptyline in human liver microsomes. Pharmacology and Toxicology 1987; 61: 342–346
  • Del Villar E., Sanchez E., Tephly T. R. The inhibition of morphine: UDP-glucuronyltransferase in rabbit liver microsomes by cyproheptadine. Life Sciences 1977; 21: 1801–1806
  • Fischer L. J., Thies R. L., Charkowski D., Donham K. J. Formation and urinary excretion of cyproheptadine glucuronide in monkeys, chimpanzees, and humans. Drug Metabolism and Disposition 1980; 8: 422–424
  • Grimmett M. R. Comprehensive Heterocyclic Chemistry, K. T. Potts. Pergamon Press, Oxford 1984; vol. 5: 352
  • Hucker H. B., Balletto A. J., Stauffer S. C., Zacchei A. G., Arison B. H. Physiological disposition and urinary metabolites of cyproheptadine in the dog, rat and cat. Drug Metabolism and Disposition 1974; 2: 406–415
  • Hucker H. B., Stauffer S. C., Balletto A. J., White S. D., Zacchei A. G., Arison B. H. Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey and man. Drug Metabolism and Disposition 1978; 6: 659–672
  • Janssen F. W., Kirkman S. K., Fenselau C., Stogniew M., Hofmann B. R., Young E. M., Ruelius H. W. Metabolic formation of N- and O-glucuronides of 3-(p-chlorophenyl)thiazole‘3,2-a’benzimidazole-2-acetic acid. Drug Metabolism and Disposition 1982; 10: 599–604
  • Kennedy K. A., Halmi K. A., Fisher L. J. Urinary excretion of a quaternary ammonium glucuronide metabolite of cyproheptadine in humans undergoing chronic drug therapy. Life Sciences 1977; 21: 1813–1820
  • LeBigot J. F., Cresteil T., Kiechel J. R., Beaune P. Metabolism of ketotifen by human liver microsomes. Drug Metabolism and Disposition 1983; 11: 585–589
  • LeBigot J. F., Begue J. M., Kiechel J. R., Guillouzo A. Species differences in metabolism of ketotifen in rat, rabbit and man: demonstration of similar pathways in vivo and in cultured hepatocytes. Life Sciences 1987; 40: 883–890
  • Lehman J. P., Fenselau C. Synthesis of quaternary ammonium-linked glucuronides by rabbit hepatic microsomal UDP-glucuronyltransferase and analysis by fast-atom bombardment mass spectrometry. Drug Metabolism and Disposition 1982; 10: 446–449
  • Lehman J. P., Fenselau C., Depaulo J. R. Quaternary ammonium-linked glucuronides of amitriptyline, imipramine and chlorpromazine. Drug Metabolism and Dispositions 1983; 11: 221–225
  • Maudsley A. A., Muller L., Ernst R. R. Cross-correlation of spin-decoupled NMR spectra by heteronuclear two-dimensional spectroscopy. Journal of Magnetic Resonance 1977; 28: 463–469
  • Midgley I., Biggs S. R., Hawkins D. R., Chasseaud L. F., Darragh A., Brodie R. R., Walmsley L. M. The metabolic fate of ‘3H’econazole in man. Xenobiotica 1981; 11: 595–608
  • Nakano M., Nakajima Y., Iwatani K., Nakagawa Y., Sugeno K. Metabolism of the antimycotic agent, croconazole, in rabbit. Drug Metabolism and Disposition 1989; 17: 323–329
  • Ogata M., Matsumoto H., Hamada Y., Takehara M., Tawara K. 1-‘1-‘2-‘3-(Chlorobenzyl)oxy’phenyl’-1H’imidazole hydrochloride, a new potent antifungal agent. Journal of Medicinal Chemistry 1983; 26: 768–770
  • Porter C. C., Arison B. H., Gruber V. F., Titus D. C., Vandenheuvel W. J. A. Human metabolism of cyproheptadine. Drug Metabolims and Disposition 1975; 3: 189–197
  • Rubin A., Dhahir P. H., Crabtree R. E., Henry D. P. The disposition of 1–3-‘(dimethylamino)-(m-dioxan-5-yl)methyl’pyridine in man. Drug Metabolism and Disposition 1979; 7: 149–154
  • Tocco D. J., Deluna F. A., Duncan A. E. W., Walker R. W., Arison B. H., Vandenheuvel W. J. A. Physiological disposition and metabolism of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride. Drug Metabolism and Disposition 1979; 7: 330
  • Walker C. H. Species variations in some hepatic microsomal enzymes that metabolize xeonbiotics. Progress in Drug Metabolism, J. W. Bridges, L. F. Chasseaud. John Wiley & Sons, New York 1980; vol. 5: 113–148

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