Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 12
16
Views
3
CrossRef citations to date
0
Altmetric
Original Article

N,N′-Diallylpentobarbital (DAPB) metabolites and their effects on pentobarbital-induced sleep and hepatic drug-metabolizing enzymes

, , , , &
Pages 1355-1368 | Received 23 Dec 1988, Accepted 15 Jun 1989, Published online: 30 Sep 2009

References

  • Allain P., Cailleux P., Leblondel G., Premel-Cabic A., Cailleux A. Recherché de la cause de l'inactive de l'hydroxypentobarbital. Biochemical Pharmacology 1975; 24: 1397–1399
  • Craig C. R., Shideman F. E. Metabolism and anticonvulsant properties of mephobarbital and phenobarbital in rats. Journal of Pharmacology and Experimental Therapeutics 1971; 176: 35–41
  • Dickert Y. J., Shea P. J., McCarty L. P. The synthesis and pharmacological activity of 5-ethyl-5-(3-hydroxy-1-methylbutyl)barbituric acid. Journal of Medicinal Chemistry 1966; 9: 249
  • Haley T. J., McCormick W. G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. British Journal of Pharmacology 1957; 12: 12–15
  • Harvey D. J., Glazener L., Johnson D. B., Butler C. M., Horning M. G. Comparative metabolism of four allylic barbiturates and hexobarbital by the rat and guinea pig. Drug Metabolism and Disposition 1977; 5: 527–546
  • Irrgang V. K. Zur pharmakologie von 5-Aethyl-5-(3-hydroxyisoamyl)barbitursäure, einem Stoffwechselprodukt der 5-Aethyl-5-isoamyl-barbitursäure. Arzneimittel-Forschung 1965; 15: 688–691
  • Levin W., Jacobson M., Sernatinger E., Kuntzman R. Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates. Drug Metabolism and Disposition 1973; 1: 275–285
  • Levin W., Sernatinger E., Jacobson M., Kuntzman R. Destruction of cytochrome P-450 by secobarbital and other barbiturates containing allyl groups. Science 1972; 176: 1341–1343
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Maynert E. W., Dawson J. M. Ethyl(3-hydroxy-1-methylbutyl)-barbituric acids as metabolites of pentobarbital. Journal of Biological Chemistry 1952; 195: 389–395
  • Mazel P. Inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF525-A). Fundamental of drug metabolism and disposition, B. N. La Du, H. G. Mandel, E. L. Way. Williams and Wilkins, Baltimore 1972; 562–566
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Tateoka Y., Kimura T., Watanabe K., Yamamoto I., Ho I. K. Mechanism of N,N'-diallylpentobarbital potentiation of pentobarbital-induced sleep in mice. Research Communications in Chemical Pathology and Pharmacology 1987; 57: 173–185
  • Vermeulen N. P. E., Bakker B. H., Schultink J., Van Der Gen A., Breimer D. D. The epoxide-diol pathway in the metabolism of hexobarbital in rat and man. Xenobiotica 1979; 9: 289–299
  • Vore M., Bush M. T. The metabolism of 1-n-butyl-5,5-diethylbarbituric acid (N-n-butyl barbital) in the rat. II. Distribution of the drug and its metabolites in various tissues in vivo and in the isolated perfused liver system. Journal of Pharmacology and Experimental Therapeutics 1980; 212: 103–108
  • Waddell W. J. The metabolic fate of 5-allyl-5-(1-methylbutyl)-barbituric acid (secobarbital). Journal of Pharmacology and Experimental Therapeutics 1965; 149: 23–28
  • Yamamoto I., Ho I. K., Loh H. H. The antagonistic effects of 5-ethyl-(3-hydroxy-l-methylbutyl)-barbituric acid on pentobarbital narcosis in both naive and tolerant mice. Life Sciences 1978; 22: 1103–1112
  • Yamamoto I., Tateoka Y., Watanabe K., Nabeshima T., Fontenot H. J., Ho I. K. The prolonging effect of N,N'-diallylpentobarbital on the drug-induced sleep and motor incoordination. Research Communications in Chemical Pathology and Pharmacology 1985; 50: 209–219

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.