Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 12
17
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster

&
Pages 1269-1280 | Received 20 Jul 1989, Accepted 15 Feb 1990, Published online: 27 Aug 2009

References

  • Brennan L. M., Creasia D. A. The effects of methapyrilene hydrochloride on hepatocarci-nogenecity and phenobarbital induced sleep time in rats and mice. Toxicology and Applied Pharmacology 1982; 66: 252–258
  • Casciano D. A., Shaddock J. G., Talska G. The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats. Mutation Research 1988; 208: 129–135
  • Degan G. H., Neumann H. G. Differences in aflatoxin B1 susceptibility of rat and mouse are correlated with the capability in vitro to inactivate aflatoxin B1-epoxide. Carcinogenesis 1981; 2: 299–306
  • Fouts J. R., Brodie B. B. Inhibition of drug metabolic pathways by the potentiating agent 2,4-dichloro-6-phenyl-phenoxyethyldiethylamine. Journal of Pharmacology and Experimental Therapeutics 1955; 115: 68–72
  • Hernandez L., Lijinsky W. Glutathione and lipid peroxide levels in rat liver following administration of methapyrilene and analogs. Chemico-Biological Interactions 1989; 69: 217–224
  • Kammerer R. C., Froines J. R., Price T. Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Food and Chemical Toxicology 1986; 24: 981–985
  • Kammerer R. C., Kloc K. Synthesis of a deuterium labelled variant of the rat hepatocarcinogen methapyrilene. Journal of Labelled Compounds and Radiophharmaceuticals 1987; 24: 1469–1477
  • Kammerer R. C., Kloc K., Lampe M. A., Schmitz D. A. Oxidation of the pyridine ring: A major pathway of metabolism for the rat hepatocarcinogen, methapyrilene. Proceedings of the Western Pharmacology Society 1987; 30: 79–83
  • Kammerer R. C., Lampe M. A. In vitro metabolism of chlorpheniramine in the rabbit. Biochemical Pharmacology 1987; 36: 3445–3452
  • Kammerer R. C., Schmitz D. A. Metabolism of methapyrilene by rat liver homogenate. Xenobiotica 1986; 16: 671–680
  • Kammerer R. C., Schmitz D. A. Species differences in the in vitro metabolism of methapyrilene. Xenobiotica 1987; 17: 1121–1130
  • Kammerer R. C., Schmitz D. A. A comparative in vitro metabolic study of methaphenilene and pyribenzamine. Xenobiotica 1988; 18: 1085–1096
  • Kammerer R. C., Schmitz D. A., Lampe M. A., Kloc K. The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat. Xenobiotica 1988; 18: 869–881
  • Lampe M. A., Kammerer R. C. The effect of chronic methapyrilene treatment on methapyrilene metabolism in vitro. Carcinogenesis 1987a; 8: 221–226
  • Lampe M. A., Kammerer R. C. Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Carcinogenesis 1987b; 8: 1525–1529
  • Lijinsky W., Knutsen G., Reuber M. D. Failure of methapyrilene to induce tumors in hamsters or guinea pigs. Journal of Toxicology and Environmental Health 1983; 12: 653–657
  • Lijinsky W., Reuber M. D., Blackwell B. N. Liver tumors induced by oral administration of the antihistamine methapyrilene hydrochloride. Science 1980; 209: 817–819
  • Lijinsky W., Yamashita K. Lack of binding of methapyrilene and similar antihistamines to rat liver DNA examined by 32P postlabeling. Cancer Research 1988; 48: 6475–6477
  • Lotlikar P. D., Jhee E. C., Insetta S. M., Clearfield M. S. Modulation of microsome mediated aflatoxin B1 binding to exogenous and endogenous DNA by cytosolic glutathione-S-transferases in rat and hamster livers. Carcinogenesis 1984; 5: 269–276
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagant. Journal of Biological Chemistry 1951; 193: 265–275
  • Lutz W. K. In vivo covalent binding of organic chemicals to DNA is a quantitative indicator in the process of chemical carcinogenesis. Mutation Research 1979; 65: 289–356
  • McQueen C. A., Williams G. M. Characterization of DNA repair elicited by carcinogens and drugs in hepatocyte primary culture/DNA repair test. Journal of Toxicology and Environmental Health 1981; 8: 463–477
  • Miller E. C., Miller J. A., Enomoto M. The comparative carcinogenecities of 2-acetylaminofluorene and its N-hydroxy metabolite in mice, hamsters and guinea pigs. Cancer Research 1964; 24: 2018–2030
  • Miller J. A., Miller E. C. The metabolic activation of carcinogenic aromatic amines and amides. Progress in Experimental Tumor Research 1969; 11: 273–301
  • Newberne P.M., Butler W. H. Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review. Cancer Research 1969; 29: 236–250
  • O'Brien K., Moss E., Judah D., Neal G. Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity. Biochemical and Biophysical Research Communications 1983; 114: 813–821
  • Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Probst G. S., Neal S. B. The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures. Cancer Letters 1980; 10: 67–73
  • Raj H. G., Clearfield M. S., Lotlikar P. D. Comparative kinetic studies on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with rat and hamster livers in vitro. Carcinogenesis 1984; 5: 879–884
  • Reddy J. K., Lalwai N. D. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Critical Reviews in Toxicology 1983; 12: 1–58
  • Singer B., Grunberger D. Metabolic activation of carcinogens and mutagens. Molecular Biology of Mutagens and Carcinogens. Plenum Press, New York 1984; 97–141
  • Steinmetz K. L., Tyson C. K., Meierhenry E. F., Spaulding J. W., Mirsalis J. C. Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Carcinogenesis 1988; 9: 959–963
  • Turner N. T., Wooley J. L., Hozier J. C., Sawyer J. R., Clive D. Methapyrilene is a genotoxic carcinogen: Studies on methapyrilene and pyrilamine in L5178Y/TK + /- mouse lymphoma assay. Mutation Research 1987; 189: 285–297
  • Ziegler D. M. Microsomal flavin-containing monooxygenases: Oxygenation of nucleophilic nitrogen and sulfur compounds. Enzymatic Basis of Detoxification, W. B. Jakoby. Academic Press, New York 1980; Vol. 1: 201–227

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.