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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 12
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Original Article

Influence of effectors of prostaglandin metabolism on the toxicity induced by 7-hydroxymethyl-12-methylbenz(a)anthracene in cultured rat adrenal cells

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Pages 1311-1318 | Received 20 Nov 1989, Accepted 25 May 1990, Published online: 27 Aug 2009

References

  • Bäärnhielm C., Hansson G. Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Biochemical Pharmacology 1986; 35: 1419–1425
  • Cavalieri E. L., Rogan E. G. One-electron oxidation in aromatic hydrocarbon carcinogenesis. Polycyclic Hydrocarbons and Carcinogenesis, E. D. Harvey. ACS Symposium Series, Washington, DC 1985; Vol. 283: 289–305
  • Cavalieri E. L., Rogan E. G., Roth R. W., Saugier R. K., Hakam A. The relationship between ionization potential and horseradish peroxidase/hydrogen peroxide-catalyzed binding of aromatic hydrocarbons to DNA. Chemico-Biological Interactions 1983; 47: 87–109
  • DiGiovanni J., Juchua M. R. Biotransformation and bioactivation of 7,12-dimethylbenz(a)anthracene (7,12-DMBA). Drug Metabolism Reviews 1980; 11: 61–101
  • Dipple A. Poly nuclear aromatic carcinogens. Chemical Carcinogens, C. E. Searle. Am. Chem. Soc. Monographs, USA 1976; vol. 173: 245–314
  • Eling T. J., Curtis J. F., Harman L. S., Mason R. P. Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. Journal of Biological Chemistry 1986; 261: 5023–5028
  • Flohé L., Beckmann R., Giertz H., Losxhen G. Oxygen centered free radicals as mediators of inflammation. Oxidative Stress, H. Sies. Academic Press, London 1985; 403–435
  • Flower R. J., Blackwell G. J. Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Nature 1979; 278: 456–459
  • Polycyclic Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, R. I. Freundenthal, P. W. Jones. Raven Press, New York 1976
  • Goldstein R. H., Wall M. Activation of protein formation and cell division by bradykinin and Des-Arg9-bradykinin. Journal of Biological Chemistry 1984; 259: 9263–9268
  • Hallberg E. Metabolism and toxicity of xenobiotics in the adrenal cortex, with particular reference to 7,12-dimethylbenz(a)anthracene. Journal of Biochemical Toxicology 1990; 5, (in press)
  • Hallberg E., Rydström J. Toxicity of 7,12-dimethylbenz(a)anthracene and 7-hydroxymethylbenz(a)anthracene and its prevention in cultured rat adrenal cells. Evidence for a peroxidative mechanism of action. Toxicology 1987; 47: 259–275
  • Hallberg E., Rydström J. Selective oxidation of mitochondrial glutathione in cultured rat adrenal cells and its relation to polycyclic aromatic hydrocarbons-induced cytotoxicity. Archives of Biochemistry and Biophysics 1989; 270: 662–671
  • Hallberg E., Rydström J. Effect of 7-hydroxymethyl-12-methylbenz(a)anthracene and 1,3-bis-(2-chloroethyl)-1-nitrosourea on enzyme activities and oxidation of glutathione in cultured rat adrenal cells. Xenobiotica 1989; 19: 315–327
  • Free Radicals in Biology and Medicine, B. Halliwell, J. M. C. Gutteridge. Clarendon Press, Oxford 1985
  • Heidelberger C. Chemical carcinogenesis. Annual Reviews of Biochemistry 1975; 44: 79–121
  • Hirata F., Schiffmann E., Venkatasubramanian K., Salomon D., Axelrod J. A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proceedings of the National Academy of Sciences, USA 1980; 77: 2533–2536
  • Muggins C. B. Experimental Leukemia and Mammary Cancer: Induction, Prevention, Cure, C. B. Huggins. University of Chicago Press, Chicago 1979
  • Lands W. E. M. Mechanisms of action of antiinflammatory drugs. Advances in Drug Research 1985; 14: 147–164
  • Lesko S., Caspary W., Lorentzen R., Tsó P. O. P. Enzymic formation of 6-oxobenzo(a)pyrene radical in rat liver homogenates from carcinogenic benzo(a)pyrene. Biochemistry 1975; 14: 3978–3984
  • Marnett L. J. Polycyclic aromatic oxidation during prostaglandin biosynthesis. Life Science 1981; 29: 531–546
  • Marnett L. J. Hydroperoxide-dependent oxygenation of polycyclic aromatic hydrocarbons and their metabolites. Polycyclic Hydrocarbons and Carcinogenesis, E. D. Harvey. ACS Symposium Series, Washington, DC 1985; Vol. 283: 307–326
  • Marshall P. J., Lands W. E. M. In vitro formation of activators for prostaglandin synthesis by neutrophils and macrophages from humans and guinea pigs. Journal of Laboratory and Clinical Medicine 1986; 108: 525–534
  • Mason R. P., Chignell C. F. Free radicals in pharmacology and toxicology—selected topics. Free Radicals in Biology and Medicine 1982; 33: 189–211
  • Metzler M., McLachlan J. A. Peroxidase-mediated oxidation, a possible pathway for metabolic activation of diethylstilbestrol. Biochemical and Biophysical Research Communications 1978; 85: 874–884
  • Moldéus P., Larsson R., Ross D. Involvement of prostaglandin synthesis in the metabolic activation of acetaminophen and phenacetin. Arachidonic Acid Metabolism and Tumor Initiation, L. J. Marnett. Martinus Nijhoff, Boston, MA 1985; 171–198
  • Nussdorfer G. G. Cytophysiology of the Adrenal cortex, International Review of Cytology. Academic Press, London 1985; Vol. 98: 91, 131
  • Okhi S., Ogino N., Yamamoto S., Hayaishi O. Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Journal of Biological Chemistry 1979; 254: 829–836
  • Pataki J., Huggins C. B. Adrenal destruction and cancer induced by hydroxyalkyl derivatives of 7,12-dimethylbenz(a)anthracene. Biochemical Pharmacology 1967; 16: 607–612
  • Potter D. W., Hinson J. A. The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase. Journal of Biological Chemistry 1987; 262: 974–980
  • Reigh D. L., Stuart M., Floyd R. A. Activation of the carcinogen N-Hydroxy-2-acetylaminofluorene by rat mammary peroxidase. Experientia 1978; 34: 107–108
  • Rogan E. G., Hakam A., Cavalieri E. L. Structure elucidation of a 6-methylbenzo(a)pyrene-DNA adduct formed by horseradish peroxidase in vitro and in mouse skin in vivo. Chemico-Biological Interactions 1983; 47: 111–122
  • Sims P., Grover P. L., Swaisland A., Pal K., Hewer A. Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide. Nature 1974; 252: 326–328
  • Smith W. L. The eicosanoids and their biochemical mechanisms of action. Biochemical Journal 1989; 259: 315–324
  • Wong P. K., Hampton M. J., Floyd R. A. Evidence for lipoxygenase-peroxidase activation of N-hydroxy-2-acetylaminoflurone by rat mammary parenchymal cells. Prostaglandins and Cancer: First International Conference, T. J. Powles, R. S. Bockman, K. V. Honn, P. Ramwell. Alan R. Liss, New York 1982; 167–179
  • Zenser T. W., Cohen S. V., Mattmammal M. B., Murasaki G., Davis B. B. Role of prostaglandin-endoperoxidase synthetase in benzidine and 5-nitrofuran-induced kidney and bladder carcinogenesis. Prostaglandins and Cancer: First International Conference, T. J. Powles, R. S. Bockman, K. V. Honn, P. Ramwell. Alan R. Liss, New York 1982; 123–141

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