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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 12
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Original Article

Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite

P. Voncken INBIFO Institut für biologische Forschung, Fuggerstrasse 3, D-5000, Körln 90, FRG
,
K. Rustemeier INBIFO Institut für biologische Forschung, Fuggerstrasse 3, D-5000, Körln 90, FRG
&
G. Schepers INBIFO Institut für biologische Forschung, Fuggerstrasse 3, D-5000, Körln 90, FRG
Pages 1353-1356 | Published online: 27 Aug 2009

References

  • Barlow R. D., Thompson P. A., Stone R. B. Simultaneous determination of nicotine, cotinine and five additional nicotine metabolites in the urine of smokers using pre-column derivatization and high-performance liquid chromatography. Journal of Chromatography 1987; 419: 375–380
  • Bowman E. R., McKennis H. Studies on the metabolism of (-)-cotinine in the human. Journal of Pharmacology and Experimental Therapeutics 1962; 135: 306–311
  • Dagne E., Castagnoli N. Structure of hydroxycotinine, a nicotine metabolite. Journal of Medicinal Chemistry 1972; 15: 356–360
  • Jacob P., Benowitz N. L., Shulgin A. T. Recent studies of nicotine metabolism in humans. Pharmacology, Biochemistry and Behavior 1988; 30: 249–253
  • Kazemi Vala E., Englund G., Curvall M. Excretion of nicotine and its major metabolites in urine. (Meeting Abstract) Fourth European Congress of Biopharmaceutics and Pharmacokinetics. Geneva 1990
  • McKennis H., Turnbull L. B., Bowman E. R., Wada E. Demethylation of cotinine in vivo. Journal of the American Chemical Society 1959; 81: 3951–3954
  • McKennis H., Turnbull L. B., Schwartz S. L., Tamaki E., Bowman E. R. Demethylation in the metabolism of (-)-nicotine. Journal of Biological Chemistry 1962; 237: 541–546
  • Neurath G. B., Dünger M., Orth D., Pein G. F. Trans-3′-hydroxycotinine as a main metatolite in urine of smokers. International Archives of Occupational and Environmental Health 1987; 59: 199–201
  • Nwosu C. G., Crooks P. A. Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica 1988; 18: 1361–1372
  • O'Doherty S. O., Revans A., Smith C. L., McBride M., Cooke M. Determination of cis-and trans-3-hydroxycotinine by high performance liquid chromatography. Journal of High Resolution Chromatography and Chromatography Communications 1988; 11: 723–725
  • Voncken P., Schepers G., Schäfer K.-H. Capillary gas chromatographic determination of trans-3′-hydrexycotinine simultaneously with nicotine and cotinine in urine and blood samples. Journal of Chromatography 1989; 479: 410–418

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