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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 1
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Original Article

Chemical synthesis of dual-radiolabelled cyclandelate and its metabolism in rat hepatocytes and mouse J774 cells

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Pages 71-79 | Received 05 Apr 1989, Accepted 26 Aug 1989, Published online: 27 Aug 2009

References

  • Clegg R. J., Middleton B., Bell G. D., White D. A. The mechanism of cyclic monoterpene inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat. Journal of Biological Chemistry 1982; 257: 2294–2299
  • Fry J. R. Preparation of mammalian hepatocytes. Methods in Enzymology 1981; 77: 130
  • Heffron F. Ph.D. thesis. The effect of cyclandelate on cholesterol esterification in rat liver and cultured J77 macrophages. University of Nottingham, UK 1988
  • Heffron F., White D. A., Middleton B. The consequences of ACAT inhibition by cyclandelate on LDL metabolism by J774 macrophages. Biological Society Transactions 1989; 17: 127
  • Middleton A., White D. A., Bell G. D., Middleton B. The in vivo inhibition of hepatic lipogenesis in the rat by cyclandelate. Biological Pharmacology 1983 b; 32: 3079–3083
  • Middleton B., Cacciaguerra F., White D. A. Cyclandelate: An inhibitor of cholesterol esterification. Drugs 1987; 33: 75–79, (Suppl. 2)
  • Middleton B., Middleton A., Miciak A., White D. A., Bell G. D. The inhibition of hepatic S-3-hydroxy-3-methylglutaryl-CoA reductase by 3,3,5-trimethylcyclohexanol and its mandelic acid ester, cyclandelate. Biological Pharmacology 1983 a; 32: 649–651
  • Middleton B., Middleton A., White D. A., Bell G. D. Dietary cyclandelate decreases pre-established atherosclerosis in the rabbit. Atherosclerosis 1984; 171: 171–178
  • Reichl D., Miller M. E. The anatomy and physiology of reverse cholesterol transport. Clinical Science 1986; 70: 221–231
  • Timmerman H. Calcium modulation and Clinical effect: profile of cyclandelate. Drugs 1987; 33: 1–4, (Suppl. 2)

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