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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 10
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Research Article

Identification of two major biliary metabolites of carvedilol in rats

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Pages 1025-1034 | Received 04 Dec 1989, Accepted 15 May 1990, Published online: 22 Sep 2008

References

  • Fujimaki M., Hakusui H. Studies on the metabolic fate of carvedilol (III). Biliary excretion and enterohepatic circulation in rats. Xenobiotic Metabolism and Disposition 1989; 4(6)667–671
  • Fujimaki M., Shintani S., Hakusui H. Studies on the metabolic fate of carvedilol (VI). Absorption, excretion and distribution in monkeys. Xenobiotic Metabolism and Disposition 1989; 4(6)693–701
  • Hakusui H., Fujimaki M., Esumi Y., Takaichi M., Saito S., Otsuki M., Miyake T., Honda S. Studies on the metabolic fate of carvedilol (I). Pharmacokinetics in the rat following a single oral dose. Xenobiotic Metabolism and Disposition 1989; 4(6)637–649
  • Neubert P. Metabolism of carvedilol in dogs. Boehringer Mannheim Investigation Report 1986
  • Neugebauer G., Akpan W., Möllendorff E. v., Neubert P., Reiff K. Pharmacokinetics and disposition of carvedilol in humans. Journal of Cardiovascular Pharmacology 1987; 10: S85–S88, (Suppl. 11)
  • Schmidt H. High pressure liquid chromatography of the carvedilol enantiomers. Boehringer Mannheim Investigation Report 1987
  • Sponer G., Bartsch W., Strein K., Müller-Beckmann B., Böhm E. Pharmacological profile of carvedilol as a β-blocking agent with vasodilating and hypotensive properties. Journal of Cardiovascular Pharmacology 1987; 9: 317–327

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