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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 10
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Research Article

Metabolism and pharmacokinetics of nufenoxole in animals and humans: an example of stereospecific hydroxylation of an isoquinuclidine ring

C. S. Cook Department of Drug Metabolism, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, 60077, USA
,
J. G. Campion Department of Drug Metabolism, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, 60077, USA
,
J. D. Hribar Department of Drug Metabolism, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, 60077, USA
&
A. Karim Department of Drug Metabolism, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, 60077, USA
Pages 1065-1080 | Received 20 Jul 1989, Accepted 27 Mar 1990, Published online: 22 Sep 2008

References

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  • Brownsill R. D., Hiley M. P., Vose C. W., Steiner J. A., Stafford J. E. H., McAllister A., Rose D. A., Gerry N. Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects. Xenobiotica 1987; 17: 1373–1377
  • Carroll F. I., Smith D., Wall M. E. Carbon-13 magnetic resonance study. Structure of the metabolites of orally administered quinidine in humans. Journal of Medicinal Chemistry 1974; 17: 985–987
  • Carroll F. I., Philip A., Coleman M. C. Synthesis and stereochemistry of a metabolite resulting from the biotransformation of quinidine in man. Tetrahedron Letters 1976; 21: 1757–1760
  • Dajani E. Z., Bianchi R. G., East P. F., Bloss J. L., Adelstein G. W., Yen C. H. The pharmacology of SC-27166: a novel antidiarrheal agent. Journal of Pharmacology and Experimental Therapeutics 1977; 203: 512–526
  • Mackerer C. R., Brougham L. R., East P. F., Bloss J. L., Dajani E. Z., Clay G. A. Antidiarrheal and central nervous system activities of SC-27166 a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus. Journal of Pharmacology and Experimental Therapeutics 1977; 203: 527–538
  • Misra A. L., Pontani R. B., Mule S. J. Pharmacokinetics and metabolism of [3H]-thebaine in the rat. Xenobiotica 1974; 4: 17–32
  • Moriarty K. F., Rolston D. D. K., Kelly M. J., Shield M., Clark M. L. Nufenoxole, a new antidiarrheal agent, inhibits fluid secretion in the human jejunum. Gut 1985; 26: 75–80

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