Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 10
27
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Biotransformation of a new pyrrolidinone cognition-enhancing agent: isolation and identification of metabolites in human urine

, , &
Pages 1081-1094 | Received 13 Nov 1989, Accepted 15 May 1990, Published online: 22 Sep 2008

References

  • Betzing H., Biederman J., Materne C., Neuser V. Pyrrolidin-2-on-1-ylacetic acid 2,6-dimethylanilide, process of preparation and pharmaceutical compositions containing them. German Patent 1980, No. DE 2924011
  • Hallstrom G., Lindeke B., Anderson E. Metabolism of N-(5-pyrrolidinopent-3-ynyl)-succinimide (BL14) in rat liver preparations. Characterization of four oxidative reactions. Xenobiotica 1981; 11: 459–471
  • Hallstrom G., Kammerer R. C., Nguyen C. H., Schmitz D. A., Di Stefano E. W., Cho A. K. Phencyclidine metabolism in vitro. The formation of a carbinolamine and its metabolites by rabbit liver preparations. Drug Metabolism and Disposition 1983; 11: 47–53
  • Hill D. L., Laster W. R., Struck R. F. Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite. Cancer Research 1972; 32: 658–665
  • Hucker H. B., Gillette J. R., Brodie B. B. Enzymatic pathway for the formation of cotinine, a major metabolite of nicotine in rabbit liver. Journal of Pharacology and Experimental Therapeutics 1960; 129: 94–100
  • Kawajiri S., Sakurai T., Ojima H., Hatanaka S., Yamasaki T., Kojima H., Akashi A. Effect of DM-9384, a new pyrrolidone derivative, on learning behavior and cerebral choline acetyltransferase activity in rats. Psychopharmacology 1988; 96, Abst. 32.02.24
  • Kubota A., Furuya I., Kurasawa M. Pharmacological study of aniracetam, II: choice reaction time-shortening action of aniracetam in aged rats (2). Japanese Pharmacology and Therapeutics 1986; 14: 55–61
  • Murasaki M., Miura S., Ishigooka J., Wakatabe H., Uchiumi M., Fukuyama Y., Mochizuki Y., Sumiyoshi A. Disposition and metabolism of DM-9384. Psychopharmacology 1988; 96, Abst. 32.02.25
  • Nabeshima T., Noda Y., Kameyama T. Effect of DM-9384, a pyrrolidone derivative, on an amnesia model animal having GABA-ergic neuronal dysfunction. Xth International Congress of Pharmacology. Sydney 1987, 23-28 August Abst. P301
  • Nabeshima T., Noda Y., Tohyama K., Harrer S., Kameyama T. Antiamnesic effects of DM-9384, a pyrrolidone derivative, on drug-induced amnesia animal models. Psychopharmacology 1988; 96, Abst. 32.02.22
  • Sakurai T., Ojima H., Hatanaka S., Yamasaki T., Kojima H., Akashi A. Effect of DM-9384, a new pyrrolidone derivative, on learning behavior in rats. Japanese Journal of Pharmacology, Supplementum 1988; 46: 0–259
  • Sekine Y., Miyamoto M., Hashimoto M., Nakamura K. Metabolism in rats and man of piromidic acid, a new antibacterial agent. Xenobiotica 1976; 6: 185–198
  • Sudo K., Hashimoto K., Fujimaki Y., Tachizawa H. Disposition and metabolism of DM-9384, a cyclic GABA derivative, in the rat, dog and monkey. Psychopharmacology 1988; 96, Abst. 32.02.25
  • Tohyama K., Nabeshima T., Kameyama T. Effect of DM-9384, a pyrrolidone derivative, on benzodiazepine-induced amnesia. Psychopharmacology 1988; 96, Abst. 32.02.23
  • Ward D. P., Trevor A. J., Kalir A., Adams J. D., Baillie T. A., Castagnoli N., Jr. Metabolism of phencyclidine. The role of iminium ion formation in covalent binding to rabbit microsomal protein. Drug Metabolism and Disposition 1982; 10: 690–695
  • Yoshida T., Ichinose M., Kataoka K., Hirota T., Moroi R. Physico-chemical properties of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384). Iyakuhin Kenkyu 1989; 20: 79–80

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.