Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

References

• Booms A. R., Brodie M. J., Kahn G. C., Fletcher D. R., Saunders J. H., Davies D. S. Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens. British Journal of Clinical Pharmacology 1980; 9: 11–19
   PubMed Web of Science ®Google Scholar
• Boobis A. R., Kahn G. C., Whyte C., Brodie M. J., Davies D. S. Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions. Biochemical Pharmacology 1981; 30: 2451–2456
   PubMed Web of Science ®Google Scholar
• Boobis A. R., Murray S., Kahn G. C., Robertz G.-M., Davies D. S. Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man. Molecular Pharmacology 1983; 23: 474–481
   PubMed Web of Science ®Google Scholar
• Boobis A. R., Davies D. S., McQuade J., Sesardic D. Specificity of isozymes of cytochrome P-450 determined by inhibitory monoclonal antibodies,. British Journal of Pharmacology 1985a; 86: 511P
   Google Scholar
• Boobis A. R., McQuade J., Sesardic D., Robson R. T., Hayward C., Lock E. A., Elcombe C. R., Rose M. S., Davies D. S. A monoclonal antibody raised to rat liver cytochrome P-448 (form c) which recognises an epitope common to many other forms of cytochrome P-450. Biochemical Pharmacology 1985; 34: 1671–1681
   PubMed Web of Science ®Google Scholar
• Boobis A. R., Murray S., Hampden C. E., Harries G. C., Huggett A. C., Thorgeirsson S. S., McManus M. E., Davies D. S. Enzymic basis for polymorphisms of drug oxidation in man. Microsomes and Drug Oxidations, A. R. Boobis, J. Caldwell, F. De Matteis, C. R. Elcombe. Taylor & Francis, London and Philadelphia 1985c; 361–369
   Google Scholar
• Boobis A. R., Seddon C. E., Davies D. S. Bufuralol 1′-hydroxylase activity of the rat. Strain differences and the effects of inhibitors. Biochemical Pharmacology 1986; 35: 2961–2965
   PubMed Web of Science ®Google Scholar
• Boobis A. R., Murray S., Seddon C. E., Davies D. S. In vitro studies of induction and inhibition of drug oxidation in man. Pharmacology and Therapeutics 1987; 33: 101–108
   PubMed Web of Science ®Google Scholar
• Breckenridge A., Orme M. L'E., Davies L., Thorgeirsson S. S., Davies D. S. Dose dependent enzyme induction. Clinical Pharmacology and Therapeutics 1973; 14: 514–520
   PubMed Web of Science ®Google Scholar
• Brodie M. J., Boobis A. R., Hillyard C. J., Abeyasekera G., Stevenson J. C., MacIntyre I., Park B. K. Effect of rifampicin and isonizaid on vitamin D metabolism. Clinical Pharmacology and Therapeutics 1982; 32: 525–530
   PubMed Web of Science ®Google Scholar
• Butler M. A., Iwasaki M., Guengerich F. P., Kadlubar F. F. Human cytochrome P-450PA (P-450 IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines,. Proceedings of the National Academy of Sciences, USA 1989; 86: 7696–7700
   PubMed Web of Science ®Google Scholar
• Conney A. H. Pharmacological implications of microsomal enzyme induction. Pharmacological Reviews 1967; 19: 317–366
   PubMed Web of Science ®Google Scholar
• Cresteil T., Beaune P., Celier C., Leroux J. P., Guengerich F. P. Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: Effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene. Journal of Pharmacology and Experimental Therapeutics 1986; 236: 269–276
   PubMed Web of Science ®Google Scholar
• Cresteil T., Jaiswal A. K., Eisen H. J. Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines. Archives of Biochemistry and Biophysics 1987; 253: 233–240
   PubMed Web of Science ®Google Scholar
• Danhof M., Krom D. P., Breimer D. D. Studies on the different metabolic pathways of antipyrine in rats: Influence of phenobarbital and 3-methylcholanthrene treatment. Xenobiotica 1979; 9: 695–702
   PubMed Web of Science ®Google Scholar
• Danhof M., Verbeek R. M. A., Van Boxtel C. J., Boeijinga J. K., Breimer D. D. Differential effects of enzyme induction on antipyrine metabolite formation. British Journal of Clinical Pharmacology 1982; 13: 379–386
   PubMed Web of Science ®Google Scholar
• Dees J. H., Masters B. S. S., Muller-Eberhard U., Johnson E. F. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver. Cancer Research 1982; 42: 1423–1432
   PubMed Web of Science ®Google Scholar
• De Matteis F., Gibbs A. H., Hollands C. N-Alkylated porphyrins: Products of inactivation of cytochrome P-450 isoenzymes by suicide substrates. Microsomes and Drug Oxidations, A. R. Boobis, J. Caldwell, F. De Matteis, C. R. Elcombe. Taylor & Francis, London and Philadelphia 1985; 265–273
   Google Scholar
• Distlerath L. M., Reilly P. E. B., Martin M. V., Davis G. G., Wilkinson G. R., Guengerich F. P. Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry 1985; 260: 9057–9067
   PubMed Web of Science ®Google Scholar
• Domin B. A., Serabjit-Singh C. J., Vanderslice R. R., Devereux T. R., Fouts J. R., Bend J. R., Philpot R. M. Tissue and cellular differences in the expression of cytochrome P-450 isozymes. IUPHAR 9th International Congress of Pharmacology, Proceedings, W. Paton, J. Mitchell, P. Turner. Macmillan Press, Basingstoke and London 1984; Vol. 3: 219–224
   Google Scholar
• Edwards R. J., Singleton A. M., Murray B. P., Sesardic D., Rich K. J., Davies D. S., Boobis A. R. An anti-peptide antibody targeted to a specific region of rat cytochrome P450IA2 inhibits enzyme activity. Biochemical Journal 1990; 266: 497–504
   PubMed Web of Science ®Google Scholar
• Fujino T., Gottlieb K., Manchester D. K., Park S. S., West D., Gurtoo H. L., Tarone R. E., Gelboin H. V. Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta. Cancer Research 1984; 44: 3916–3923
   PubMed Web of Science ®Google Scholar
• Gibson G. G. Comparative aspects of the mammalian cytochrome P450 IV gene family. Xenobiotica 1989; 19: 1123–1148
   PubMed Web of Science ®Google Scholar
• Goldstein J. A., Linko P. Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues. Molecular Pharmacology 1984; 25: 185–191
   PubMed Web of Science ®Google Scholar
• Gonzalez F. J. The molecular biology of cytochrome P450s. Pharmacological Reviews 1989; 40: 243–288
   Web of Science ®Google Scholar
• Gonzalez F. J., Skoda R. C., Kimura S., Umeno M., Zanger U. M., Nebert D. W., Gelboin H. V., Hardwick J. P., Meyer U. A. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 1988; 331: 442–446
   PubMed Web of Science ®Google Scholar
• Gonzalez F. J., Tukey R. H., Nebert D. W. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Molecular Pharmacology 1984; 26: 117–121
   PubMed Web of Science ®Google Scholar
• Mammalian Cytochromes P-450, F. P. Guengerich. CRC Press, Boca Raton, FL 1987
   Google Scholar
• Guengerich F. P. Characterization of human microsomal cytochrome P-450 enzymes. Annual Reviews of Pharmacology and Toxicology 1989; 29: 241–264
   PubMed Web of Science ®Google Scholar
• Guengerich F. P., Wang P., Davidson N. K. Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gell electrophoresis. Biochemistry 1982; 21: 1698–1706
   PubMed Web of Science ®Google Scholar
• Guenthner T. M., Nebert D. W. Evidence in rat and mouse liver for temporal control of two forms of cytochrome P-450 inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin. European Journal of Biochemistry 1978; 91: 449–456
   PubMedGoogle Scholar
• Hong J., Pan J., Dong Z., Ning S. M., Yang C. S. Regulation of N-nitrosodimethylamine demethylase in rat liver and kidney. Cancer Research 1987; 47: 5948–5953
   PubMed Web of Science ®Google Scholar
• Huang M.-T., Chang R. L., Fortner J. G., Conney A. H. Studies on the mechanism of activation of microsomal benzo[α]pyrene hydroxylation by flavonoids. Journal of Biological Chemistry 1981; 256: 6829–6836
   PubMed Web of Science ®Google Scholar
• Ivy S. P., Tulpule A., Fairchild C. R., Averbuch S. D., Myers C. E., Nebert D. W., Baird W. M., Cowan K. H. Altered regulation of P-450IA1 expression in a multidrug-resistant MCG-7 human breast cancer cell line. Journal of Biological Chemistry 1988; 263: 19119–19125
   PubMed Web of Science ®Google Scholar
• Jaiswal A. K., Nebert D. W., Gonzalez F. J. Human P3450: cDNA and complete amino acid sequence. Nucleic Acids Research 1986; 14: 6773–6774
   PubMed Web of Science ®Google Scholar
• Johnson E. F., Muller-Eberhard U. Multiple forms of cytochrome P-450: Resolution and purification of rabbit liver aryl hydrocarbon hydroxylase. Biochemical and Biophysical Research Communications 1977; 76: 644–651
   PubMed Web of Science ®Google Scholar
• Jollow D. J., Thorgeirsson S. S., Potter W. Z., Hashimoto M., Mitchell J. R. Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology 1974; 12: 251–271
   PubMed Web of Science ®Google Scholar
• Kelley M., Hantelle P., Safe S., Levin W., Thomos P. E. Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2′,4′,5′-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene. Molecular Pharmacology 1987; 32: 206–211
   PubMed Web of Science ®Google Scholar
• Khani S. C., Porter T. D., Fujita V. S., Coon M. J. Organization and differential expression of two highly similar genes in the rabbit alcohol-inducible cytochrome P-450 subfamily. Journal of Biological Chemistry 1988; 263: 7170–7175
   PubMed Web of Science ®Google Scholar
• Kimura S. C., Porter T. D. F. J., Nebert D. W. Tissue-specific expression of the mouse dioxin-inducible P1450 and P3450 genes: Differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Molecular and Cellular Biology 1986; 6: 1471–1477
   PubMed Web of Science ®Google Scholar
• Kobayashi S., Murray S., Watson D., Sesardic D., Davies D. S., Boobis A. R. The specificity of inhibition of debrisoquine 4-hydroxylase activity in quinidine and quinine in the rat is the inverse of that in man. Biochemical Pharmacology 1989; 38: 2795–2799
   PubMed Web of Science ®Google Scholar
• Kojo A., Honkakoski P., Järvinen P., Pelkonen O., Lang M. Preferential inhibition of mouse hepatic coumarin 7-hydroxylase by inhibitors of steroid metabolizing monooxygenases. Pharmacology and Toxicology 1989; 65: 104–109
   PubMedGoogle Scholar
• Koop D. R., Coon M. J. Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment. Molecular Pharmacology 1984; 25: 494–501
   PubMed Web of Science ®Google Scholar
• Kupfer A., Preisig R. Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. European Journal of Clinical Pharmacology 1984; 26: 753–759
   PubMed Web of Science ®Google Scholar
• Kutt H., Louis S. Anticonvulsant drugs. II. Clinical, pharmacological and therapeutic aspects. Drugs 1982; 4: 256–282
   Google Scholar
• Kutt H., Verebely K., McDowell F. Inhibition of diphenylhydantoin metabolism in rats and in rat liver microsomes by antitubercular drugs. Neurology 1968; 18: 706–710
   PubMed Web of Science ®Google Scholar
• Lang M. A., Juvonen R., Järvinen P., Honkakoski P., Raunio H. Mouse liver P450Coh: Genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. Archives of Biochemistry and Biophysics 1989; 271: 139–148
   PubMed Web of Science ®Google Scholar
• Manno M., De Matteis F., King L. J. The mechanism of suicidal, reductive inactivation of microsomal cytochrome P-450 by carbon tetrachloride. Biochemical Pharmacology 1988; 37: 981–1990
   PubMed Web of Science ®Google Scholar
• Matsunaga E., Zanger U. M., Hardwick J. P., Gelboin H. V., Meyer U. A., Gonzalez F. J. The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Biochemistry 1989; 28: 7349–7355
   PubMed Web of Science ®Google Scholar
• Miners J. O., Lillywhite K. J., Matthews A. P., Birkett D. J. In vitro assessment of UDP-glucuronosyltransferase multiplicity and substrate specificity in human liver. Microsomes and Drug Oxidations, Proceedings of the 7th International Symposium, J.O. Miners, D.J. Birkett, R. Drew, B. K. May, M. E. McManus. Taylor & Francis, London and Philadelphia 1988; 279–286
   Google Scholar
• Mitchell J. R., Jollow D. J., Potter W. Z., Davis D. C., Gillette J. R., Brodie B. B. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. Journal of Pharmacology and Experimental Therapeutics 1973; 187: 185–194
   PubMed Web of Science ®Google Scholar
• Murray S., Boobis A. R. An assay for paracetamol, produced by the O-deethylation of phenacetin in vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry. Biomedical and Environmental Mass Spectrometry 1986; 13: 91–93
   PubMedGoogle Scholar
• Murray B. P., Boobis A. R., De La Torre R., Segura J., Davies D. S. Inhibition of dietary mutagen activation by methylxanthines. Biochemical Society Transactions 1988; 16: 620–621
   Web of Science ®Google Scholar
• Murray B. P., Boobis A. R., Sesardic D., Edwards R. J., Davies D. S. The role of cytochrome P-450 LM4 in the activation of the dietary carcinogen MelQx. Human Toxicology 1989; 7: 383
   Google Scholar
• Murray B. P., Sesardic D., Davies D. S., Boobis A. R. Species differences in specificity of hydrocarbon-inducible forms of cytochrome P450. Biochemical Society Transactions 1989; 17: 1021–1022
   PubMed Web of Science ®Google Scholar
• Nebert D. W., Jones J. E. Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene. International Journal of Biochemistry 1989; 21: 243–252
   PubMedGoogle Scholar
• Nebert D. W., Nelson D. R., Adesnik M., Coon M. J., Estabrook R. W., Gonzalez F. J., Guengerich F. P., Gunsalus I. C., Johnson E. F., Kemper B., Levin W., Phillips I. R., Sato R., Waterman M. R. The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA 1989; 8: 1–13
   PubMedGoogle Scholar
• Norman R. L., Johnson E. F., Muller-Eberhard U. Identification of the major cytochrome P-450 form transplacentally induced in neonatal rabbits by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of Biological Chemistry 1978; 253: 8640–8647
   PubMed Web of Science ®Google Scholar
• Ohnhaus E. E., Park B. K. Measurement of urinary 6-β-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbital and rifampicin. European Journal of Clinical Pharmacology 1979; 15: 139–145
   PubMed Web of Science ®Google Scholar
• Okino S. T., Quattrochi L. C., Barnes H. J., Osanto S., Griffin K. J., Johnson E. F., Tukey R. H. Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p- dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6. Proceedings of the National Academy of Sciences, USA 1985; 82: 5310–5314
   PubMed Web of Science ®Google Scholar
• Parkinson R., Safe S. H., Robertson L. W., Thomas P. E., Ryan D. E., Reik L. M., Levin W. Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. Journal of Biological Chemistry 1983; 258: 5967–5976
   PubMed Web of Science ®Google Scholar
• Pasanen M., Stacey S., Lykkesfeldt A., Briand P., Hines R., Autrup H. Induction of cytochrome P-450IA1 gene expression in human breast tumour cell lines. Chemico-Biological Interactions 1988; 66: 223–232
   PubMed Web of Science ®Google Scholar
• Pasanen M., Stenbäck F., Taskinen T., Raunio H., Sivonen P., Hines R., Pelkonen O. Human placental 7-ethoxyresorufin O-deethylase activity: Inhibition studies and immunological and molecular biological detection of P450IA1. Cytochrome P-450: Biochemistry and Biophysics, I. Schuster. Taylor & Francis, London, New York and Philadelphia 1989; 532–535
   Google Scholar
• Pelkonen O., Sotaniemi E. A., Ahokas J. T. Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons. British Journal of Clinical Pharmacology 1985; 19: 59–66
   PubMed Web of Science ®Google Scholar
• Peng R., Tu Y. Y., Yang C. S. The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol. Carcinogenesis 1984; 4: 1457–1461
   Google Scholar
• Peters J. H. Studies on the metabolism of isonizaid. American Review of Respiratory Diseases 1960; 81: 485–497
   PubMedGoogle Scholar
• Poland A., Mak I., Glover E. Species differences in responsiveness to 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Molecular Pharmacology 1981; 20: 442–450
   PubMed Web of Science ®Google Scholar
• Porter T. D., Khani S. C., Coon M. J. Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes. Molecular Pharmacology 1989; 36: 61–65
   PubMed Web of Science ®Google Scholar
• Potter W. Z., Thorgeirsson S. S., Jollow D. J., Mitchell J. R. Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology 1974; 12: 129–143
   PubMed Web of Science ®Google Scholar
• Quattrochi L. C., Tukey R. H. The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Molecular Pharmacology 1989; 36: 66–71
   PubMed Web of Science ®Google Scholar
• Raucy J., Fernandes P., Black M., Yang S. L., Koop D. R. Identification of a human liver cytochrome P-450 exhibiting catalytic and immunochemical similarities to cytochrome P-450 3a of rabbit liver. Biochemical Pharmacology 1987; 36: 2921–2926
   PubMed Web of Science ®Google Scholar
• Raunio H., Syngelmä T., Pasanen M., Juvonen R., Honkakoski P., Kairaluoma M. A., Sotaniemi E., Lang M. A., Pelkonen O. Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse. Biochemical Pharmacology 1988; 37: 3889–3895
   PubMed Web of Science ®Google Scholar
• Rich K. J., Edwards R. J., Foster J. R., Davies D. S., Boobis A. R. Ontogeny of expression, inducibility and distribution of cytochromes P-450 forms 4 and 6 in rabbit liver. Biochemical Society Transactions 1989; 17: 1023–1024
   PubMed Web of Science ®Google Scholar
• Ryan D. E., Thomas P. E., Korzeniowski D., Levin W. Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rate treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene. Journal of Biological Chemistry 1979; 254: 1365–1374
   PubMed Web of Science ®Google Scholar
• Ryan D. E., Thomas P. E., Levin W. Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. Journal of Biological Chemistry 1980; 255: 7941–7955
   PubMed Web of Science ®Google Scholar
• Sesardic D., Boobis A. R., McQuade J., Baker S., Lock E. A., Elcombe C. R., Robson R. T., Hayward C., Davies D. S. Inter-relatedness of some isoenzymes of cytochrome P-450 from rat, rabbit and human, determined with monoclonal antibodies. Biochemical Journal 1986; 236: 569–577
   PubMed Web of Science ®Google Scholar
• Sesardic D., Boobis A. R., Edwards R. J., Davies D. S. A form of cytochrome P450in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. British Journal of Clinical Pharmacology 1988; 26: 363–372
   PubMed Web of Science ®Google Scholar
• Sesardic D., Edwards R. J., Davies D. S., Boobis A. R. Hepatic suppression of cytochrome P450c catalysed O-deethylation of phenacetin. Cytochrome P-450: Biochemistry and Biophysics, I. Schuster. Taylor & Francis, London, New York and Philadelphia 1989a; 870–873
   Google Scholar
• Sesardic D., Rich K. J., Edwards R. J., Davies D. S., Boobis A. R. Selective destruction of cytochrome P-450d and associated monooxygenase activity by carbon tetrachloride in the rat. Xenobiotica 1989; 19: 795–811
   PubMed Web of Science ®Google Scholar
• Sesardic D., Boobis A. R., Murray B. P., Murray S., Segura J., De La Torre R., Davies D. S. Furafylline is a potent and selective inhibitor of cytochrome F4501A2 in man. British Journal of Clinical Pharmacology 1990; 29: 651–663
   PubMed Web of Science ®Google Scholar
• Sesardic D., Cole K. J., Edwards R. J., Davies D. S., Thomas P. E., Levin W., Boobis A. R. The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues. Biochemical Pharmacology 1990; 39: 499–506
   PubMed Web of Science ®Google Scholar
• Sesardic D., Edwards R. J., Davies D. S., Thomas P. E., Levin W., Boobis A. R. High affinity phenacetin O-deethylase is catalysed spedifically by cytochrome P450d (P450IA2) in the liver of the rat. Biochemical Pharmacology 1990; 39: 489–498
   PubMed Web of Science ®Google Scholar
• Shaw P. M., Barnes T. S., Cameron D., Engeset J., Melvin W. T., Omar G., Petrie J. C., Rush W. R., Snyder C. P., Whiting P. H., Wolf C. R., Burke M. D. Purification and characterization of an anticonvulsant-induced human cytochrome P-450 catalysing cyclosporin metabolism. Biochemical Journal 1989; 263: 653–663
   PubMed Web of Science ®Google Scholar
• Sogawa K., Gotoh O., Kawajiri K., Harada T., Fujii-Kuriyama Y. Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. Journal of Biological Chemistry 1985; 260: 5026–5032
   PubMed Web of Science ®Google Scholar
• Song B. J., Gelboin H. V., Park S. S., Yang C. S., Gonzalez F. J. Complementary DNA and protein sequences of ethanol-inducible rat and human P-450s: transcriptional and post-transcriptional regulation of the rat enzyme. Journal of Biological Chemistry 1986; 261: 16689–16697
   PubMed Web of Science ®Google Scholar
• Tee L. B. G., Davies D. S., Seddon C. E., Boobis A. R. Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. Biochemical Pharmacology 1987; 36: 1041–1052
   PubMed Web of Science ®Google Scholar
• Testa B., Jenner P. Inhibitors of cytochrome P-450s and their mechanism of action. Drug Metabolism Reviews 1981; 12: 1–117
   PubMed Web of Science ®Google Scholar
• Thomas P. E., Korzeniowski D., Ryan D., Levin W. Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes. Archives of Biochemistry and Biophysics 1979; 192: 524–532
   PubMed Web of Science ®Google Scholar
• Thomas P. E., Reik L. M., Ryan D. E., Levin W. Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. Journal of Biological Chemistry 1983; 258: 4590–4598
   PubMed Web of Science ®Google Scholar
• Thomas P. E., Reidy J., Reik L. M., Ryan D. E., Koop D. R., Levin W. Use of monoclonal antibody probes against rat hepatic cytochromes P450c and P450d to detect immunochemically related isozymes in liver microsomes from different species. Archives of Biochemistry and Biophysics 1984; 235: 239–253
   PubMed Web of Science ®Google Scholar
• Thomas P. E., Reik L. M., Ryan D. E., Levin W. Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes. Journal of Biological Chemistry 1984; 259: 3890–3899
   PubMed Web of Science ®Google Scholar
• Thomas P. E., Bandiera S., Maines S. L., Ryan D. E., Levin W. Regulation of cytochrome P-450j, a high affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry 1987; 26: 2280–2289
   PubMed Web of Science ®Google Scholar
• Thorgeirsson S. S., Atlas S. A., Boobis A. R., Felton J. S. Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals. Biochemical Pharmacology 1979; 28: 217–226
   PubMed Web of Science ®Google Scholar
• Umbenhauer D. R., Martin M. V., Lloyd R. S., Guengerich F. P. Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase. Biochemistry 1987; 26: 1094–1099
   PubMed Web of Science ®Google Scholar
• Umeno M., McBride O. W., Yang C. S., Gelboin H. V., Gonzalez F. J. Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. Biochemistry 1988; 27: 9006–9013
   PubMed Web of Science ®Google Scholar
• Umeno M., Song B. J., Kozak C., Gelboin H. V., Gonzalez F. J. The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping and correlation of development expression with specific 5′-cytosine demethylation. Journal of Biological Chemistry 1988; 263: 4956–4962
   PubMed Web of Science ®Google Scholar
• Uotila P., Pelkonen O., Cohen G. M. The effect of cigarette smoke on the metabolism of [3H]benzo[a]pyrene by rat lung microsomes. Cancer Research 1977; 37: 2156–2161
   PubMed Web of Science ®Google Scholar
• Vesell E. S., Page J. G. Genetic control of drug levels in man: antipyrine. Science 1968; 161: 72–73
   PubMed Web of Science ®Google Scholar
• Whitlock J. P. The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Pharmacological Reviews 1987; 39: 147–161
   PubMed Web of Science ®Google Scholar
• Wong T. K., Domin B. A., Bent P. E., Blanton T. E., Anderson M. W., Philpot R. M. Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans. Cancer Research 1986; 46: 999–1004
   PubMed Web of Science ®Google Scholar
• Yasumori T., Murayama N., Yamazoe Y., Abe A., Nogi Y., Fukasawa T., Katu R. Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system. Molecular Pharmacology 1989; 35: 443–449
   PubMed Web of Science ®Google Scholar
• Zhi-Guang T., Murray B., Sesardic S., Kobayashi S., Murray S., Davies D.S., Boobis A. R. Quinidine discriminates between rat and human debrisoquine 4-hydroxylase. British Journal of Clinical Pharmacology 1988; 25: 674P
   Web of Science ®Google Scholar