Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 11
111
Views
36
CrossRef citations to date
0
Altmetric
Original Article

Design of toxicokinetic studies

, &
Pages 1187-1199 | Received 07 Oct 1989, Accepted 23 Apr 1990, Published online: 27 Aug 2009

References

  • Caccia S., Dagnino G., Garattini S., Guiso G., Madonna R., Zanini M. G. Kinetics of fenfluramine isomers in the rat. European Journal of Drug Metabolism and Pharmacokinetics 1981; 6: 297–301
  • Caccia S., Ballatio M., Guiso G., Rocchetti M., Garattini S. Species differences in the kinetics and metabolism of fenfluramine isomers. Archives Internationales Pharmacodynamics 1982; 258: 15–28
  • Clark B., Smith D. A. Pharmacokinetics and toxicity testing. Critical Reviews in Toxicology 1984; 12: 343–385
  • Clark B., Smith D. A. Drug metabolism studies in safety evaluation. Progress on Drug Metabolism, G. G. Gibson. Taylor & Francis, London 1988; Vol. 11: 175–216
  • Davies D. S. An introduction to metabolic and kinetic aspects of toxicological studies. Xenobiotica 1988; 18: 3–7, (Suppl. 1)
  • Hoffman K. Toxicology studies with nitrendipine,. Nitrendipine, A. Scriabine, S. Vanou, K. Deck. Urban & Schwarzenberg, Baltimore and Munich 1984; 25–32
  • Holt D. W., Tucker G. T., Jackson P. R., Storey G. C. A. Amiodarone pharmacokinetics. American Heart Journal 1983; 106: 840–847
  • Humphrey M. J., Filer C. W., Jeffery D. J., Langley P. F., Wadds G. A. The availability of carfecillin and its phenol moiety in rat and dog. Xenobiotica 1980; 10: 771–778
  • Kannan R., Matin-Asgari A. Dose dependant tissue uptake of flecainide during chronic administration in rabbits. Drug Metabolism and Disposition 1988; 16: 228–231
  • Latini R., Bizzi A., Cini M., Veneroni E., Marchi S., Riva E. Amiodarone and desethylamiodarone tissue uptake in rats chronically treated with amiodarone is non-linear with dose. Journal of Pharmacy and Pharmacology 1987; 39: 426–431
  • Manners C. N., Payling D. W., Smith D. A. Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes. Xenobiotica 1988; 18: 331–350
  • Nau H. Species differences in pharmacokinetics, drug metabolism and teratogenesis. Pharmacokinetics in Teratogenesis, H. Nau, W. J. Scott. CRC Press, Boca Raton, Florida 1987; Vol. 1: 81–106
  • Sugimoto I., Kuchiki A., Nakagawa H., Tohgo K., Kondo S., Iwane I., Takahashi K. Dissolution and absorption of nifedipine from nifedipine-polyvinylpyrrolidine coprecipitate. Drug Development and Industrial Pharmacy 1980; 6(2)137–160
  • Sullivan H. R., Hanasono G. K., Miller W. M., Wood P. G. Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes. Xenobiotica 1987; 17: 459–468
  • Wedlund P. J., Aslanian W. S., Jacqz E., McAllister C. B., Branch R. A., Wilkinson G. R. Phenotypic differences in mephenytoin pharmacokinetics in normal subjects. Journal of Pharmacology and Experimental Therapeutics 1985; 234: 662–669

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.