Age-related changes in biotransformation of azoxymethane and methylazoxymethanol in vitro

References

• Baird M. B., Birnbaum L. S. Increased production of mutagenic metabolites of carcinogens by tissues from senescent rats. Cancer Research 1979; 39: 4752–4755
   PubMed Web of Science ®Google Scholar
• Birnbaum L. S. Age-related changes in carcinogen metabolism. Journal of the American Geriatric Society 1987; 35: 51–60
   PubMed Web of Science ®Google Scholar
• Chakravarthy A., Elsayed A., Ullah A., Shamsuddin A. K. M. Azoxymethane induced large intestinal carconogenesis in Fischer 344 rats. A two-dimensional dose and time model. Federation Proceedings 1987; 46(3)744
   Google Scholar
• Craven P. A., Neidig M., Derubertis F. R. Fatty acid stimulated oxidation of methylazoxymethanol by rat colonic mucosa. Cancer Research 1985; 45: 1115–1121
   PubMed Web of Science ®Google Scholar
• Dutton D. J. Extrahepatic glucuronidation. Glucuronidation of Drugs and Other Compounds. CRC Press, Boca Raton 1980; 149–152
   Google Scholar
• Eacho P. I., Sweeney D., Weiner M. Conjugation of p-nitroanisole and p-nitrophenol in hepatocytes isolated from streptozotocin diabetic rats. Journal of Pharmacology and Experimental Therapeutics 1981; 218: 34–40
   PubMed Web of Science ®Google Scholar
• Feinberg A., Zedeck M. S. Production of a highly reactive alklylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase. Cancer Research 1980; 40: 4446–4450
   PubMed Web of Science ®Google Scholar
• Fiala E. S. Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer 1977; 40: 2436–2445
   PubMed Web of Science ®Google Scholar
• Fiala E. S., Bobotas G., Kulakis C., Weisberger J. Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine treated rats. Journal of the National Cancer Institute 1976; 56: 1271–1273
   PubMedGoogle Scholar
• Fiala E. S., Kulakis C., Christiansen G., Weisberger J. H. Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole. Cancer Research 1978; 38: 4515–4521
   PubMed Web of Science ®Google Scholar
• Fiala E. S., Sohn O. S., Hamilton S. R. Effect of chronic dietary ethanol on in vivo and in vitro metabolism of MAM and on MAM-induced DNA methylation in rat colon and liver. Cancer Research 1987; 47: 5939–5943
   PubMed Web of Science ®Google Scholar
• Glauert H. P., Bennink M. Metabolism of 1,2-dimethylhydrazine by cultured rat colon epithelial cells. Nutrition and Cancer 1983; 5(2)78–86
   PubMedGoogle Scholar
• Goldin B. R. In situ bacterial metabolism and colon mutagens,. Annual Review of Microbiology 1986; 40: 367–393
   PubMed Web of Science ®Google Scholar
• Goldin B., Gorbach S. Effect of antibiotics on incidence of rat intestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. Journal of the National Cancer Institute 1981; 67(4)877–880
   PubMedGoogle Scholar
• Grab D. J., Zedeck M. S. Organ specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases. Cancer Research 1977; 37: 4182–4189
   PubMed Web of Science ®Google Scholar
• Isselbacher K. J., Axelrod J. Enzymatic formation of corticosteroid glucuronides. Journal of the American Chemical Society 1955; 77: 1070–1071
   Web of Science ®Google Scholar
• Koster A. Intestinal glucuronidation: in vivo and in vitro model systems. Advances in Glucuronde Conjugation, S. Matern, K. W. Bock, W. Gerok. MTP Press, Lancaster 1984; 177–195
   Google Scholar
• Koster A., Frankhuijzen-Sierevogel A., Noordhoek J. Distribution of glucuronidation capacity (1-naphthol and morphine) along the rat intestine. Biochemical Pharmacology 1985; 34(19)3527–3532
   PubMed Web of Science ®Google Scholar
• Lamont J. T., O'Gorman T. A. Experimental colon cancer. Gastroenterology 1978; 75: 1157–1169
   PubMed Web of Science ®Google Scholar
• Laqueur G. L., McDaniel E. G., Matsumoto H. Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate. Journal of the National Cancer Institute 1967; 39: 355–371
   PubMedGoogle Scholar
• Likhachev A., Anisimov V., Parvaova L., Pozharisski K. Effect of exogenous β-glucuronidase on the carcinogenicity of 1,2-dimethylhydrazine in rats: evidence that carcinogenic intermediates form conjugates and act through their subsequent enzymatic release. Carcinogenesis 1985; 6(5)579–681
   PubMed Web of Science ®Google Scholar
• Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Matsumoto H., Takata R., Ishizaki H. Determination of the carcinogen methylazoxymethanol-β-D-glucosiduronic acid in rat bile and urine. Journal of Chromatography 1981; 211: 403–408
   PubMed Web of Science ®Google Scholar
• McMahon T. F., Beierschmitt W. P., Weiner M. Changes in phase I and phase II biotransformation pathways with age in male Fischer 344 rat colon: relationship to colon carcinogenesis. Cancer Letters 1987; 36: 273–282
   PubMed Web of Science ®Google Scholar
• Metzger U., Meier J., Uhlschmid G., Weihe H. Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer. Diseases of the Colon and Rectum 1984; 27(6)366–369
   PubMed Web of Science ®Google Scholar
• Newaz S. N., Fang W., Strobel H. W. Metabolism of the colon carcinogen 1,2-dimethylhydrazine by isolated human colon microscomes and human colon cells in culture. Cancer 1983; 52(5)794–798
   PubMed Web of Science ®Google Scholar
• Nigro N., Bull A., Boyd M. Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil. Journal of the National Cancer Institute 1986; 77(6)1309–1313
   PubMedGoogle Scholar
• Notman J., Tan Q., Zedeck M. S. Inhibition of methylazoxymethanol induced intestinal tumors in rhe rat by pyrazole with paradoxical effects on skin and kidney. Cancer Research 1982; 42: 1774–1780
   PubMed Web of Science ®Google Scholar
• Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes. I. evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
   PubMed Web of Science ®Google Scholar
• Oravec C. T., Jones C., Huberman E. Activation of the colon carcinogen 1,2-Dimethylhydrazine in a rat colon cell-mediated mutagenesis assay. Cancer Research 1986; 46: 5068–5071
   PubMed Web of Science ®Google Scholar
• Reddy B. S., Maruyama H. Effect of dietary fish oil on azoxymethane induced colon carcinogenesis in male F344 rats. Cancer Research 1986; 46: 3367–3370
   PubMed Web of Science ®Google Scholar
• Reddy B. S., Maruyama H., Kelloff G. Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a non-steroidal anti-inflammatory drug, during different states of rat colon tumor development. Cancer Research 1987; 47: 5340–5346
   PubMed Web of Science ®Google Scholar
• Rikans L. E. Influence of ageing on the activities of rat liver enzymes used as markers for hepatotoxicity. IRCS Medical Science 1986; 14: 467–468
   Google Scholar
• Shamsuddin A. K. M., Weiss L., Phelps P., Trump B. F. Colon epithelium IV: Human colon carcinogenesis. Changes in human colon mucosa adjacent to and remote from carcinomas of the colon. Journal of the National Cancer Institute 1981; 66: 413–419
   PubMedGoogle Scholar
• Siest G., Antoine B., Fournel S., Magdalou J., Thomassin J. The glucuronyltransferases: what progress can pharmacologists expect from molecular biology and cellular enzymology?. Biochemical Pharmacology 1987; 36(7)983–989
   PubMed Web of Science ®Google Scholar
• Sohn O., Fiala E. S., Puz C., Hamilton S., Williams G. Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: similarity to the microsomal metabolism of N-nitrosodimethylamine. Cancer Research 1987; 47: 3123–3129
   PubMed Web of Science ®Google Scholar
• Takada H., Hirooka T., Hiramatsu Y., Yamamoto M. Effect of β-glucuronidase inhibitor on azoxymethane-indiced colonic carcinogenesis in rats. Cancer Research 1982; 42: 331–334
   PubMed Web of Science ®Google Scholar
• Tallarida R. J., Murray R. B. Manual of Pharmacologic Calculations with Computer Programs 2nd edn. Springer- Verlag, New York 1987
   Google Scholar
• Teas H. J. Cycasin synthesis in Seirarctia echo (Lepidoptera) larvae fed methylazoxymethanol. Biochemical and Biophysical Research Communications 1967; 26: 686–690
   PubMed Web of Science ®Google Scholar
• Ullrich D., Bock K. W. Glucuronide formation of various drugs in liver microsomes and in isolated hepatocytes from phenobarbital and 3-methylcholanthrene treated rats. Biochemical Pharmacology 1984; 33: 97–101
   PubMed Web of Science ®Google Scholar
• Weisberger J. H. Colon carcinogens: their metabolism and mode of action. Cancer 1971; 28: 60–70
   PubMed Web of Science ®Google Scholar
• Weisberger J. H., Fiala E. S. Experimental colon carcinogens and their mode of action. Experimental Colon Carcinogenesis, H. Autrup, G. M. Williams. CRC Press, Boca Raton 1983; 27–50
   Google Scholar
• Wittig V. G., Wildner G. P., Zeibarth D. Der einfluss der ingesta auf die cancerisierung des rattendarms durch dimethylhydrazine. Archiv für Geschwulstforschung 1971; 37: 105–115
   PubMedGoogle Scholar
• Zedeck M. S., Sternberg S. A model system for studies of colon carcinogenesis: tumor induction by a single injection of methylazoxymethanol acetate. Journal of the National Cancer Institute 1974; 53(5)1419–1421
   PubMedGoogle Scholar
• Zedeck M. S., Grab D. J., Sternberg S. Differences in the acute response of the various segments of rat intestine to treatment with the intestinal carcinogen, methylazoxymethanol acetate. Cancer Research 1977; 37: 32–36
   PubMed Web of Science ®Google Scholar