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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 5
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Original Article

The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration I. Disposition and metabolic profiling

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Pages 515-524 | Received 16 Jan 1989, Accepted 28 Dec 1989, Published online: 27 Aug 2009

References

  • Bickel M. H., Willi P., Gigon P. L. Species and substrate differences of liver microsomal N-dealkylation and N-oxidation of tertiary amines and N-dealkylation of N-oxides. Xenobiotica 1971; 1: 533–534
  • Burns R. S., Chiueh C. C., Markey S. P., Ebert M. H., Jacobowitz D. M., Kopin Y. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proceedings of the National Academy of Sciences 1983; 80: 4546–4550
  • Crosson C. E., Burke J. A., Chan M. F., Potter D. E. Ocular effects of a N,N-disubstituted 5-OH aminotetralin (N-0437): evidence for a dual mechanism of action. Current Eye Research 1987; 6: 1319–1326
  • Drenth B. F. H., de Zeeuw R. A. Radiochemical purity control of radiolabelled drugs. International Journal of Applied Isotopes 1982; 33: 681–683
  • Gerding T. K., Drenth B. F. H., de Zeeuw R. A., Tepper P. G., Horn A. S. The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration. II. Isolation and identification of metabolites. Xenobiotica 1990; 20: 525–536
  • Hollenberg P. F., Miwa G. T., Walsh J. S., Dwyer L. A., Rickert D. E., Kedderis G. L. Mechanisms of N-demethylation reactions catalyzed by cytochrome P-450 and peroxidases. Drug Metabolism and Disposition 1985; 13: 272–275
  • Horn A. S., Tepper P., van der Weide J., Watanabe M., Grigoriadis G., Seeman P. Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist. Pharmaceutisch Weekblad Scientific Edition 1985; 7: 208–211
  • Hornykiewicz O. Brain dopamine in Parkinson's disease and other neurological disturbances. The Neurobiology of Dopamine, A. S. Horn, J. Korf, B. H. C. Westerink. Academic Press, New York 1979; 633–654
  • Horrocks D. L. A new method of quench monitoring in liquid scintillation counting: the H number concept. Journal of Radioanalytical Chemistry 1978; 43: 489–521
  • Iwamoto K., Klaassen C. D. First-pass effect of nalorphine in rats. Journal of Pharmacology and Experimental Therapeutics 1977; 203: 365–376
  • Jimenez R., Esteller A., Lopez M. A. Biliary secretion in conscious rabbits: surgical technique. Laboratory Animals 1982; 16: 182–185
  • Koble D. L., Koons J. C., Fischer L. J. Metabolism and disposition of the dopaminergic agonist 5-hydroxy-6-methyl-2-di-n-propylaminotetralin in the rat. Drug Metabolism and Disposition 1985; 13: 305–311
  • Kuipers F., Havinga R., Bosschieter H., Toorop G. P., Hindriks F. R., Vonk R. J. Enterohepatic circulation in the rat. Gastroenterology 1985; 88: 403–411
  • Lesher R. J., Bender G. R., Marquis R. E. Bacteriolytic action of fluoride ions. Antimicrobial Agents and Chemotherapy 1977; 12: 339–345
  • Lindeke B., Cho A. K. Metabolic significance and pharmacological consequences of N-dealkylation. The Metabolic Basis of Detoxication, W. B. Jakoby, J. R. Bend, J. Caldwell. Academic Press, New York 1982; 119–122
  • Mulder G. J., Scholtens E., Meijer D. K. F. Collection of metabolites in bile and urine from the rat. Methods in Enzymology, W. B. Jakoby. Academic Press, New York 1981; Vol. 77: 21–30
  • Rance M. J., Shillingford J. S. The role of the gut in the metabolism of strong analgesics. Biochemical Pharmacology 1976; 25: 735–741
  • Steffens A. B. A method for frequent sampling of blood and continuous infusion of fluids in the rat without disturbing the animal. Physiology and Behavior 1969; 4: 833–836
  • Strubbe J. H. A small swivel joint for infusion of free moving animals. Physiology and Behavior 1974; 12: 317–319
  • Tamminga C. A., Gotts M. D., Thaker G. K., Alphs C. D., Foster N. L. Dopamine agonist treatment of schizophrenia with N-propylnorapomorphine. Archives of General Psychiatry 1986; 43: 398–402
  • Van der Weide J., de Vries J. B., Tepper P. G., Horn A. S. Pharmacological profiles of three new, potent and selective dopamine receptor agonists: N-0434, N-0437 and N-0734. European Journal of Pharmacology 1986; 125: 273–282
  • Van der Weide J., de Vries J. B., Tepper P. G., Horn A. S. In vitro binding of the very potent and selective D-2 dopamine agonist, [3H] N-0437 to calf caudate membranes. European Journal of Pharmacology 1987; 134: 211–219
  • Van der Weide J., de Vries J. B., Tepper P. G., Krause D. N., Dubocovich M. L., Horn A. S. N-0437: a selective D-2 dopamine receptor agonist in in vitro and in vivo models. European Journal of Pharmacology 1988; 147: 249–258
  • Vonk R. J., van Doorn A. B. D., Strubbe J. H. Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow. Clinical Science and Molecular Medicine 1978; 55: 253–259
  • Wiseman A. In. Pharmacology of Fluorides, Handbook of Experimental Pharmacology, F. A. Smith. Springer-Verlag, Berlin 1970; Vol. XX/2: 48–97

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