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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 5
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Original Article

The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration II. Isolation and identification of metabolites

T. K. Gerding Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands; Duphar B. V., P. O. Box 900, 1380 DA, Weesp, The Netherlands
,
B. F. H. Drenth Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
,
R. A. De Zeeuw Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
,
P. G. Tepper Department of Medicinal Chemistry, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
&
A. S. Horn Department of Medicinal Chemistry, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
Pages 525-536 | Received 16 Jan 1989, Accepted 28 Dec 1989, Published online: 27 Aug 2009

References

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  • Gerding T. K., Drenth B. F. H., Roosenstein H. J., De Zeeuw R. A., Tepper P. G., Horn A. S. The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration. I. Disposition and metabolic profiling. Xenobiotica 1990; 20: 515–524
  • Gerding T. K., Drenth B. F. H., De Zeeuw R. A. Separation of N-0437 enantiomers by RP-HPLC after pre-column derivatization with D(+)-glucuronic acid. Journal of High Resolution Chromatography and Chromatography Communications 1987; 10: 523–525
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