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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 6
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Original Article

Effect of pyridoxine on the disposition and lymphopenic effects of 2-acetyl-4(5)-tetrahydroxybutyl imidazole in the rat

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Pages 555-562 | Received 03 Feb 1989, Accepted 30 Jun 1989, Published online: 27 Aug 2009

References

  • Conway C. T., Paine A. J. Studies on constituents of ‘ammonia caramel’: the lymphopenic effects of substituted pyridines and 2-acetyl-4-tetrahydroxybutyl imidazole in the rat. Biochemical Society Transactions 1986; 14: 1041–1042
  • Gobin S. J. P., Legg R. F., Paine A. J., Phillips J. A. The effect of 2-acetyl-4-tetrahydroxybutyl imidazole on lymphocyte subsets in the peripheral blood of the rat. International Journal of Immunopharmacology 1989; 11: 937–946
  • Halweg K. M., Buchi G. A convenient synthesis of 2-acetyl-4(5)-[1(R),2(S),3(R),4-tetrahydroxybutyl]-imidazole. Journal of Organic Chemistry 1985; 50: 1134–1136
  • Kroplein U., Rosdorfer J., van der Greef J., Long R. C., Goldstein J. H. 2-acetyl-4(5)-(1,2,3,4 tetrahydroxybutyl)-imidazole: detection in commercial caramel color 111 and preparation by a model browing reaction. Journal of Organic Chemistry 1985; 50: 1131–1133
  • Noltes A. W., Chappel C. A. In Toxicology of Caramel Colours: Current Status in Food Toxicology, G. G. Gibson, R. Walker. Taylor & Francis, London 1985; 214–228
  • Patey A. L., Shearer G., Knowles M. E., Denner W. H. B. Ammonia caramels: specifications and analysis. Food Additives and Contaminants 1985; 2: 107–112
  • Searle A. J. F., Stewart A. C., Paul M. The measurement of ethylenethiourea and ethyleneurea in the rat and common marmoset Callithrix jacchus after zineb (zinc ethylene bisdithiocarbamate) dosing. Xenobiotica 1987; 17: 733–740
  • Sinkeldam E. J., de Groot A. P., van den Berg H., Chappel C. I. The effects of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (111). Food Chemistry Toxicology 1988; 26: 195–203

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