Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 6
44
Views
36
CrossRef citations to date
0
Altmetric
Original Article

Metabolic studies on pentachlorophenol (PCP) in rats

&
Pages 573-582 | Received 04 Oct 1989, Accepted 30 Dec 1989, Published online: 27 Aug 2009

References

  • Ahlborg U. G., Larsson K. Metabolism of tetrachlorophenols in the rat. Archives of Toxicology 1978; 40: 63–74
  • Ahlborg U. G., Lindgren J. E., Mercier M. Metabolism of pentachlorophenol. Archives of Toxicology 1974; 32: 271–281
  • Ahlborg U. G., Thunberg T. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the in vivo and in vitro dechlorination of pentachlorophenol. Archives of Toxicology 1978; 40: 55–61
  • Angerer J., Heinrich R., Laudehr H. Occupational exposure to hexachlorocyclohexane. International Archives of Occupational and Environmental Health 1981; 48: 319–324
  • Bose A. K., Fujiwara H. Fate of pentachlorophenol in the blue crab. Pentachlorophenol, K. Ranga Rao. Plenum Press, New York 1978; 83–88
  • Braun W. H., Young J. D., Sauerhoff M. W., Blau G. E., Gehring P. J. The pharmacokinetics and metabolism of pentachlorophenol in rats and monkeys. Toxicology and Applied Pharmacology 1976; 37: 94
  • Edgerton T. R., Moseman R. F., Linder R. E., Wright L. H. Multi-residue method for the determination of chlorinated phenol metabolites in urine. Journal of Chromatography 1979; 170: 331–342
  • Engst R., Macholz R. M., Kujawa M., Lewerenz H. J., Plass R. The metabolism of lindane and its metabolites gamma-2,3,4,5,6-pentachlorocyclohexene, pentachlorobenzene and pentachlorophenol in rats and the pathways of lindane metabolism. Journal of Environmental Science and Health 1976; 11: 95–117
  • Farquharson M. E., Gage J. C., Northover J. The biological action of chlorophenols. British Journal of Pharmacology 1958; 13: 20–24
  • Gallagher R. P., Threlfall W. J. Cancer and occupational exposure to chlorophenols. Lancet 1984; 48
  • Hardell L., Eriksson M., Lenner P., Lundgren E. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. British Journal of Cancer 1981; 43: 169–176
  • In Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Bd. 2/2, Analysen in biolog. Material, D. Henschler. Verlag Chemie, Weinheim 1981
  • Jacobson J., Yllner S. Metabolism of 14C-pentachlorophenol in the mouse. Acta Pharmacologia et Toxicologia 1971; 29: 513–524
  • Juhl U., Blum K., Witte I. The in vitro metabolites of 2,4,6-trichlorophenol and their DNA strand breaking properties. Chemical and Biological Interactions 1989; 69: 333–344
  • Ommen B., Adang A. E. P., Brader L., Posthumus M. A., Müller F., van Bladeren P. J. The microsomal metabolism of hexachlorobenzene. Biochemical Pharmacology 1986; 35: 3233–3238
  • Renner G. Biotransformation of the fungicides hexachlorobenzene and pentachloronitrobenzene. Xenobiotica 1981; 11: 435–446
  • Renner G. Urinary excretion of pentachlorophenol (PCP) and its metabolite tetrachlorohydro-quinone (TCH) in rats. Toxicological and Environmental Chemistry 1989; 25: 29–32
  • Renner G., Hopfer C. Preparations and properties of transformation products of pentachlorophenol (PCP). Toxicological and Environmental Chemistry 1989; 25: 105–108
  • Renner G., Mücke W. Transformation of pentachlorophenol. Part I: Metabolism in animals and man. Toxicological and Environmental Chemistry 1986; 11: 9–29
  • Renner G. Hexachlorobenzene and its metabolism. Toxicological and Environmental Chemistry 1988; 18: 51–78
  • Renner G., Hopfer C., Gokel J. M. Acute toxicities of pentachlorophenol, pentachloroanisole, tetrachlorohydroquinone, tetrachlorocatechol, tetrachlororesorcinol, tetrachlorodimethoxybenzenes and tetrachlorobenzenediol diacetates administered to mice. Toxicological and Environmental Chemistry 1986; 11: 37–50
  • Renner G., Hopfer C., Gokel J. M., Braun S., Mücke W. Subacute toxicity studies on pentachlorophenol (PCP), and the isomeric tetrachlorobenzenediols tetrachlorohydroquinone (TCH), tetrachlorocatechol (TCC), and tetrachlororesorcinol (TCR). Toxicological and Environmental Chemistry 1987; 15: 301–312
  • Tashiro S., Sasamoto T., Ajkawa T., Tokunaga S., Taniguchi E., Eto M. Metabolism of pentachlorophenol in mammals. Journal of the Agricultural Chemical Society of Japan 1970; 44: 124–129
  • Weinbach E. C. The effect of pentachlorophenol on oxidative phosphorylation. Journal of Biological Chemistry 1954; 210: 545–550
  • Witte I., Juhl U., Butte W. DNA-damaging properties and cytotoxicity in human fibroblasts of tetrachlorohydroquinone, a pentachlorophenol metabolite. Mutation Research 1985; 145: 71–75

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.