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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 7
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Original Article

Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine

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Pages 727-738 | Received 23 Oct 1989, Accepted 10 Jan 1990, Published online: 27 Aug 2009

References

  • Baier-Weber B., Prox A., Wachsmuth H., Breyer-Pfaff U. Glucuronides of hydroxylated metabolites of amitriptyline and nortriptyline isolated from rat bile. Drug Metabolism and Disposition 1988; 16: 490–496
  • Bickel M. H. Metabolism of antidepressants,. Psychotropic Agents: Handbook of Experimental Pharmacology, F. Hoffmeister, G. Stille. Springer, Berlin 1980; Vol. 55/I: 551–572
  • Bickel M. H., Minder R., Di Francesco C. Formation of N-glucuronide of desmethyl-imipramine in the dog. Experientia 1973; 29: 960–961
  • Breyer-Pfaff U., Ewert M., Wiatr R. Comparative single-dose kinetics of amitriptyline and its N-oxide in a volunteer. Arzneimittelforschung/Drug Research 1978; 28: 1916–1920
  • Breyer-Pfaff U., Prox A., Wachsmuth H., Yao P. Phenolic metabolites of amitriptyline and nortriptyline in rat bile. Drug Metabolism and Disposition 1987; 15: 882–889
  • Dahl-Puustinen M.-L., Åberg-Wistedt A., Bertilsson L. Glucuronidation of amitriptyline in man in vivo. Pharmacology and Toxicology 1989; 65: 37–39
  • Eschenhof E., Rieder J. Untersuchungen über das Schicksal des Antidepressivums Amitriptylin im Organismus der Ratte und des Menschen. Arzneimittelforschung/Drug Research 1969; 19: 957–966
  • Lauterbach F. Intestinal permeation of organic bases and quaternary ammonium compounds,. Pharmacology of Intestinal Permeation II. Handbook of Experimental Pharmacology, T. Z. Csaky. Springer, Berlin 1984; Vol. 70/II: 271–299
  • Lehman J. P., Fenselau C., DePaulo J. R. Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine. Drug Metabolism and Disposition 1983; 11: 221–225
  • McMahon R. E., Marshall F. J., Culp H. W., Miller W. M. The metabolism of nortriptyline-N-methyl-14C in rats. Biochemical Pharmacology 1963; 12: 1207–1217
  • Nusser E., Nill K., Breyer-Pfaff U. Enantioselective formation and disposition of (E)- and (Z)-10-hydroxynortriptyline. Drug Metabolism and Disposition 1988; 16: 509–511
  • Nusser E., Nill K., Breyer-Pfaff U. Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. Journal of Chromatography Biomedical Applications 1990; 528, in press
  • Prox A., Breyer-Pfaff U. Amitriptyline metabolites in human urine: Identification of phenols, dihydrodiols, glycols, and ketones. Drug Metabolism and Disposition 1987; 15: 890–896
  • Roth W., Beschke K., Jauch R., Zimmer A., Koss F. W. Fully automated high-performance liquid chromatography. A new chromatograph for pharmacokinetic drug monitoring by direct injection of body fluids. Journal of Chromatography 1981; 222: 13–22
  • Vandel B., Sandoz M., Vandel S., Allers G., Volmat R. Biotransformation of amitriptyline in depressive patients: urinary excretion of seven metabolites. European Journal of Clinical Pharmacology 1982; 22: 239–245

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