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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 8
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Original Article

Interspecies comparison of the metabolic pathways of perindopril, a new angiotensin-converting enzyme (ACE) inhibitor

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Pages 787-800 | Received 01 Nov 1988, Accepted 07 Mar 1990, Published online: 27 Aug 2009

References

  • Drummer O. H., Kourtis S. Biotransformation studies of di-acid angiotensin converting enzyme inhibitors. Arzneimittel-Forschung/Drug Research 1987; 37: 1225–1228
  • Drummer O. H., Rowley K., Johnson H., Worland P., Workman B., Harris Q. L. G., Conway E. L., Louis W. J. Metabolism and pharmacodynamics of angiotensin converting enzyme with special reference to perindopril. Excerpta Medica 1987; 750: 545–550
  • Drummer O. H., Kourtis S., Iakovidis D. Biotransformation studies of di-acid angiotensin converting enzyme inhibitors. Arzneimittel-Forschung/Drug Research 1988; 38: 647–650
  • Eckert H. G., Badian M. J., Gantz D., Kellner H. M., Volz M. Pharmacokinetics and biotransformation of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-2-alanyl]-(1S, 3S, 5S)-2 aziobicycle [3.3.0] octane-3-carboxylic acid (HOe 498) in rat, dog and man. Arzneimittel-Forschung/Drug Research 1984; 34: 1435–1446
  • Fournel-Gigleux S., Magdalou J., Laraurie C., Grislain L., Garnier M. H., Dabe J. F., Luijten W., Bromet N., Devissaguet M. Glucuronidation of perindopril by hepatic microsomes: interspecies comparison. Cellular and Molecular Aspects of Glucuronidation, G. Siest, J. Magdalou, B. Burchell. INSERM: Libbey Eurotext Ltd. 1988; Vol. 173: 305–309
  • Tocco D. J., Deluna F. A., Duncan A. E. W., Vassil T. C., Ulm E. H. The physiological disposition and metabolism of elanapril maleate in laboratory animals. Drug Metabolism and Disposition 1982; 10: 15–19
  • Vincent M., Remond G., Portein B., Serkiz B., Laubie M. Stereoselective synthesis of a new perhydroindole derivative of chiral imunodiacid, a potent inhibitor of angiotensin converting enzyme. Tetrahedron Letters 1982; 23: 1677–1680

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