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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 8
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Original Article

Oxidative transformation of paxilline in sheep bile

P. G. Mantle Biochemistry Department, Imperial College of Science, Technology and Medicine, University of London, South Kensington, London, SW7 2AY, UK
,
S. J. Burt Biochemistry Department, Imperial College of Science, Technology and Medicine, University of London, South Kensington, London, SW7 2AY, UK
,
K. M. Macgeorge Biochemistry Department, Imperial College of Science, Technology and Medicine, University of London, South Kensington, London, SW7 2AY, UK
,
J. N. Bilton Chemistry Department, Imperial College of Science, Technology and Medicine, University of London, South Kensington, London, SW7 2AY, UK
&
R. N. Sheppard Chemistry Department, Imperial College of Science, Technology and Medicine, University of London, South Kensington, London, SW7 2AY, UK
Pages 809-821 | Received 15 May 1989, Accepted 04 Apr 1990, Published online: 27 Aug 2009

References

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  • Gallagher R. T., Hawkes A. D., Steyn P. S., Vleggaar R. Tremorgenic neurotoxins from perennial ryegrass causing ryegrass staggers disorder of livestock: structure elucidation of lolitrem B. Journal of the Chemical Society Chemical Communications 1984; 614–616
  • Gysi P. G. Die Konstitution des paspalicins. Dissertation 5163. ETH, Zürich 1973
  • Hayaishi O. Oxygenases. Academic Press, New York 1962
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  • Ibba M., Taylor J. C., Weedon C. M., Mantle P. G. Submerged fermentation of Penicillium paxilli biosynthesising paxilline, a process inhibited by calcium-induced sporulation. Journal of General Microbiology 1987; 133: 3109–3119
  • Ikeda M., Ohno K., Takahashi M., Uno T., Tamura Y., Kido M. Synthesis of 1H-1-benzazepines by thermolysis of 2a,7b-dihydro-3H-cyclobut(b) indoles. Journal of the Chemical Society Perkin Transactions 1982; I: 741–748
  • Laws I., Mantle P. G., Smith B. L. Excretion and transformation of [14C]penitrem mycotoxins in sheep bile. Research in Veterinary Science 1987; 43: 199–202
  • Mantle P. G., Mortimer P. H., White E. P. Mycotoxic tremorgens of Claviceps paspali and Penicillium cyclopium: a comparative study of effects on sheep and cattle in relation to natural staggers syndromes. Research in Veterinary Science 1978; 24: 49–56
  • Mantle P. G., Penn J. A role for paxilline in the biosynthesis of indole-diterpenoid penitrem mycotoxins. Journal of the Chemical Society Perkin Transactions 1989; I: 1539–1540
  • Matsuura T. Biomimetic oxygenation. Tetrahedron 1977; 33: 2869–2905
  • Ranganathan S., Ranganathan D., Singh S. K. 4-t-butyl iodoxybenzene: an effective ozone equivalent. Tetrahedron Letters 1985; 26: 4955–4956
  • Springer J. P., Clardy J., Wells J. M., Cole R. J., Kirksey J. W. The structure of paxilline, a tremorgenic metabolite of Penicillium paxilli Bainer. Tetrahedron Letters 1975; 30: 2531–2534
  • Steyn P. S., Vleggaar R. Tremorgenic mycotoxins. Fortschritte der chemie organischer naturstoffe 1985; 48: 1–80
  • Weedon C. M., Mantle P. G. Paxilline biosynthesis by Acremonium loliae; a step towards defining the origin of lolitrem neurotoxins. Phytochemistry 1987; 26: 969–971

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