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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 2
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Research Article

Metabolic fate of indometacin farnesil, a prodrug of indomethacin: characteristic biotransformation of indometacin farnesil in rats

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Pages 135-146 | Received 22 Dec 1988, Accepted 14 Sep 1989, Published online: 22 Sep 2008

References

  • Arita T., Miyazaki K., Kohri N., Saitoh H. The behavior in gastrointestinal tract and biliary excretion of acemetacin. Yakugaku zasshi 1981; 105: 477–483
  • Bloomstrand R., Forsgren L. Vitamin K1-3H in man. Its intestinal absorption and transport in the thoracic duct lymph. Internal. Z. Vit. forschung 1968; 38: 45–64
  • Bollman J. L., Cain J. C., Grindlay J. H. Techniques for the collection of lymph from the liver, mall intestine, or throacic duct of the rat. Journal of Laboratory and Chemical Medicine 1948; 33: 1349–1352
  • Brodie D. A., Cook P. G., Bauer J., Dagle G. E. Indomethacin-induced intestinal lesions in the rat. Toxicology and Applied Pharmacology 1970; 17: 615–624
  • Dell H.-D., Doersing M., Fischer W., Jacobi H., Kamp R. Zur Biochemie von Acemetacin. Arzneimittel Forschung Drug Research 1980; 30(II)1371–1383
  • Duggan D. E., Hooke K. F., Noll R. M., Kwan K. C. Enterohepatic circulation of indomethacin and its role in intestinal irritation. Biochemical Pharmacology 1975; 24: 1749–1754
  • Elsom L. F., Chasseaud L. F., Ray J., Hawkins D. R. The disposition of the antiinflammatory agent 14C-1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetehydroxamic acid (oxametacine) in the rat. Arzneimittel Forschung/Drug Research 1979; 29(II)1155–1160
  • Favero A. D. Side effects of drug; anti-inflammatory analgesics and drug used rheumatism and gout. Excerpta Medica 1981; 10: 88–117
  • Gibaldi M. Pharmacokinetics,. Biopharmaceutics and Clinical Pharmacokinetics, 3rd edn, M. Gibaldi. Lea & Febiger, Philadelphia 1984; 10
  • Granon S., Semeriva M. Effect of taurodeoxycholate, colipase and temperature on the intestinal inactivation of procine pancreatic lipase. European Journal of Biochemistry 1980; 111: 117–124
  • Hart F. D., Huskisson E. C. Non-steroidal anti-inflammatory drugs: current status and rational therapeutic use,. Drugs 1984; 24: 232–255
  • Hucker H. B., Zacchei A. G., Cox S. V., Brodie D. A., Cantwell N. H. R. Studies on the absorption, distribution and excretion of indomethacin in various species. Journal of Pharmacology and Experimental Therapeutics 1966; 153: 237–248
  • Katayama K., Fujita T. Studies on lymphatic absorption of 1,2-3H-Coenzyme Q10 in rat. Chemical and Pharmaceutical Bulletins 1972; 20: 2585–2592
  • Kobayashi S., Shirota H., Katoh Y., Hashida R., Nagaoka J., Abe S., Yamatsu I. Anti-inflammatory activity of a new nonsteroidal anti-inflammatory prodrug, indometacin farnesil, in experimental animals. Pharmacometrics 1988; 36: 91–98
  • Levy E., Shafrir E., Ziv E., Bar-On H. Composition, removal and metabolic fate of chyromicrons derived from diabetic rats,. Biochimica et Biophysica Acta 1985; 834: 376–385
  • Nishizawa Y., Yamada K., Yamato C., Fujita T. Metabolic fate of geranylgeranylacetone. Xenobiotic Metabolism and Disposition 1986; 1: 71–77
  • Sieber S. M., Cohn V. H., Wynn W. T. The entry of foreign compounds into the thoracic duct lymph of rat. Xenobiotica 1974; 4: 265–284
  • Van Arman C. G., Begany A. J., Miller L. M., Pless H. H. Some details of the inflamations caused by yeast and carrageenin. Journal of Pharmacology and Experimental Therapeutics 1965; 150: 328–334
  • Verbreeck R. K., Blackburn J. L., Loewen G. R. Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs,. Clinical Pharmacokinetics 1983; 8: 297–331
  • Yesair D. W., Callahan M., Remington L., Kensler C. J. Role of the entero-hepatic cycle of indomethacin on its metabolism, Distribution in tissues and its excretion by rats, dog and monkeys,. Biochemical Pharmacology 1970; 19: 1579–1590

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