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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 2
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Research Article

Aspirin acetylates the tricyclic antidepressant amoxapine spontaneously to N-acetylamoxapine in vitro and in vivo

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Pages 169-176 | Received 21 Mar 1989, Accepted 10 Sep 1989, Published online: 22 Sep 2008

References

  • Bender M. L. Mechanisms of catalysis of nucleophilic reactions of carboxylic acid derivatives. Chemical Reviews 1960; 60: 53–113
  • Clarke E. G. C. Isolation and Identification of Drugs. Pharmaceutical Press, London 1974; 801
  • Clarke E. G. C. Isolation and Identification of Drugs. Pharmaceutical Press, London 1986; 348
  • Edwards L. J. The hydrolysis of aspirin. Transactions of the Faraday Society 1950; 46: 723–735
  • Garrett E. R. The kinetics of solvolysis of acyl esters of salicylic acid. Journal of the American Chemical Society 1957; 79: 3401–3408
  • Greenblatt E. N., Hardy R. A., Kelly R. G. Amoxapine,. Pharmacological and Biochemical Properties of Drug Substances, M. E. Goldberg. American Pharmaceutical Association, Washington 1979; 1–18
  • Halmekoski J., Mustonen R. Acyl migration between acetylsalicylic acid and tyramine. Farmaseuttinen Aikakauslehti Farmaceutiskt Notisblad 1966; 75: 357–371
  • Halmekoski J., Vesalainen K. Acyl migration between acetylsalicylic acid and p-hydroxyamphetamine and selective acetylation of p-hydroxyamphetamine. Farmaseuttinen Aikakauslehti Farmaceutiskt Notisblad 1969; 78: 249–256
  • Jacobs A. L., Dilatush A. E., Weinstein S., Windheuser J. J. Formation of acetylcodeine from aspirin and codeine. Journal of Pharmaceutical Sciences 1966; 55: 893–895
  • Lin W., Frade P. D. Quantitative determination of amoxapine and maprotiline and their metabolites in serum by HPLC. Clinical Chemistry 1986; 32: 1056
  • Litovitz T. L., Troutman W. G. Amoxapine overdose seizures and fatalities. Journal of the American Medical Association 1983; 250: 1069–1071
  • Osiewicz R. J., Middleberg R. Detection of a novel compound after overdoses of aspirin and amoxapine. Journal of Analytical Toxicology 1989; 13: 97–99
  • Pinckard R. N., Hawkins D., Farr R. S. In vitro acetylation of plasma proteins, enzymes and DNA by aspirin. Nature 1968; 219: 68–69
  • Rainsford K. D. Aspirin and the Salicylates. Butterworths, Boston 1984; 67–147
  • Ratnayake W. M. N., Timmins A., Ohshima T., Ackman R. G. Mass spectra of fatty acid derivatives, of isopropylidenes of novel glyceryl ethers of cod muscle and of phenolic acetates obtained with the Finnigan MAT ion trap detector. Lipids 1986; 21: 518–524
  • Schwartz M. A., Amidon G. L. Reaction of aspirin with amines: potential mechanism for aspirin allergy. Journal of Pharmaceutical Sciences 1966; 55: 1464–1465
  • Troup A. E., Mitchner H. Degradation of phenylephrine hydrochloride in tablet formulations containing aspirin. Journal of Pharmaceutical Sciences 1964; 53: 375–379

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