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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 1
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Original Article

The in vivo blood, fat and muscle concentrations of lignocaine and bupivacaine in the hindquarters of sheep

R. N. Upton Department of Anaesthesia and Intensive Care, The Flinders University of South Australia, Flinders Medical Centre, Bedford Park, SA, 5042, Australia
,
C. Nancarrow Department of Anaesthesia and Intensive Care, The Flinders University of South Australia, Flinders Medical Centre, Bedford Park, SA, 5042, Australia
,
C. F. McLean Department of Anaesthesia and Intensive Care, The Flinders University of South Australia, Flinders Medical Centre, Bedford Park, SA, 5042, Australia
,
L. E. Mather Department of Anaesthesia and Intensive Care, The Flinders University of South Australia, Flinders Medical Centre, Bedford Park, SA, 5042, Australia
&
W. B. Runciman Department of Anaesthesia and Intensive Care, The Flinders University of South Australia, Flinders Medical Centre, Bedford Park, SA, 5042, Australia
Pages 13-22 | Received 13 Nov 1989, Accepted 30 Jul 1990, Published online: 27 Aug 2009

References

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  • Nancarrow C., Runciman W. B., Mather L. E., Upton R. N., Plummer J. L. The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of sheep. Anesthesia and Analgesia 1987; 66: 925–935
  • Runciman W. B., Mather L. E. The effects of anaesthesia on drug disposition. Drugs in Anaesthesia: Mechanisms of Action, S. A. Feldman, C. F. Scurr, W. Paton. Edward Arnold, London 1986; 87–122
  • Runciman W. B., Ilsley A. H., Mather L. E., Carapetis R. J., Mao M. M. A sheep preparation for the study on the interaction between blood flow and drug disposition. I. Physiological profile. British Journal of Anaesthesia 1984a; 56: 1015–1028
  • Runciman W. B., Mather L. E., Ilsley A. H., Carapetis R. J., Upton R. N. A sheep preparation for the study of the interaction between blood flow and drug disposition. III. Effects of general and spinal anaesthesia on regional blood flow and oxygen tensions. British Journal of Anaesthesia 1984b; 56: 1247–1258
  • Tucker G. T., Mather L. E. Properties, absorption, and disposition of local anesthetic agents. Neural Blockade in Clinical Anaesthesia and Management of Pain, M. J. Cousins, P. O. Bridenbaugh. J. B. Lippincott, Philadelphia 1988; 47–110
  • Upton R. N. Regional pharmacokinetics. I. Physiological and physicochemical basis. Biopharmaceutics and Drug Disposition 1990; 11: 647–662
  • Upton R. N., Runciman W. B., Mather L. E., Carapetis R. J., McLean C. F. The uptake and elution of lignocaine and procainamide in the hindquarters of the sheep described using mass balance principles. Journal of Pharmacokinetics and Biopharmaceutics 1988a; 16: 31–40
  • Upton R. N., Mather L. E., Runciman W. B., Nancarrow C. The use of mass balance principles to describe regional drug distribution and elimination. Journal of Pharmacokinetics and Biopharmaceutics 1988b; 16: 13–29
  • Upton R. N., Mather L. E., Runciman W. B., McLean C. F., Carapetis R. J. The uptake and elution of chlormethiazole, pethidine and minaxolone in the hindquarters of the sheep—implications for clearance calculations. Journal of Pharmaceutical Sciences 1990, (In press)
  • Upton R. N., Mather L. E., Runciman W. B. The in vitro uptake and metabolism of lignocaine, procainamide and pethidine by tissues of the hindquarters of sheep. Xenobiotica 1991; 21: 1–12

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