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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 1
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Original Article

The disposition of loxistatin and metabolites in normal and dystrophic hamsters

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Pages 23-31 | Received 21 Dec 1989, Accepted 22 Jun 1990, Published online: 27 Aug 2009

References

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  • Fukushima K., Arai M., Tamai M., Yokoo C., Murata M., Suwa T., Satoh T. Metabolic fate of loxistatin in rat. Xenobiotica 1990; 20: 1043–1051
  • Jasmin G., Procheck L. Hereditary polymopathy and cardiomyopathy in the Syrian hamster. I. Progression of heart and skeletal muscle lesions in the UM-X 7.1 line. Muscle and Nerve 1982; 5: 20–25
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  • Tamai M., Ohmura S., Kimura M., Hanada K., Sugita H. Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistatin (EST). Journal of Pharmacobio-Dynamics 1987a; 10: 678–681
  • Tamai M., Yokoo C., Murata M., Oguma K., Sota K., Sato E., Kanaoka Y. Efficient synthetic method for ethyl(+)-(2S,3S)-3-‘(S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl’-2–oxiranecarboxylate (EST), a new inhibitor of cysteine proteinases. Chemical and Pharmaceutical Bulletin 1987b; 35: 1098–1104

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