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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 1
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Original Article

Metabolism of chlorpheniramine in rat and human by use of stable isotopes

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Pages 97-109 | Received 27 Feb 1990, Accepted 18 May 1990, Published online: 27 Aug 2009

References

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  • Huang S.-M., Huang Y.-C., Chiou W. L. Oral absorption and presystemic first-pass effect of chlorpheniramine in rabbits. Journal of Pharmacokinetics and Biopharmaceutics 1981; 9(6)725–738
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  • Peets E. A., Weinstein R., Billard W., Symchowicz S. The metabolism of chlorpheniramine maleate in the dog and rat. Archives Internationales de Pharmacodynamie 1972b; 199: 172–190
  • Peter K., Marilyn T., Edward T. Urinary excretion of chlorpheniramine and its N-demethylated metabolites in man. Journal of Pharmaceutical Science 1968; 57(5)856–858
  • Siek T. J., Rieders E. F. Formation of 2-(4-chlorophenoxy)-2-methylpropanamide from a clofibrate metabolite during extraction of urine. Journal of Analytical Toxicology 1981; 5: 194–197
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  • Thompson J. A., Leffert F. H. Sensitive GLC-mass spectrometric determination of chlorpheniramine in serum. Journal of Pharmaceutical Science 1980; 69(6)707–710

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