Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 4
Submit an article Journal homepage
10
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Chronic ethanol consumption causes increased glucuronidation of morphine in rabbits

S. S. Narayan College of Pharmacy, and Graduate Program in Pharmacology/Toxicology, Washington State University, Pullman, Washington, 99164-6510, USA
,
W. L. Hayton College of Pharmacy, and Graduate Program in Pharmacology/Toxicology, Washington State University, Pullman, Washington, 99164-6510, USA
&
G. S. Yost Department of Pharmacology and Toxicology, 112 Skaggs Hall, University of Utah, Salt Lake City, Utah, 84112, USA
Pages 515-524 | Received 01 May 1990, Accepted 09 Jul 1990, Published online: 27 Aug 2009

References

  • Brunk S. F., Delle M. Morphine metabolism in man. Clinical Pharmacology and Therapeutics 1974; 16: 51–57
  • Christensen C. B., Jorgensen L. N. Morphine-6-glucuronide has high affinity for the opioid receptor. Pharmacology and Toxicology 1987; 60: 75–76
  • Finley B. L., Ashley P. J., Neptune A. G., Yost G. S. Substrate-selective induction of rabbit hepatic UDP-glucuronyltransferases by ethanol and other xenobiotics. Biochemical Pharmacology 1986; 35: 2875–2881
  • Houston J. B. Drug metabolite kinetics. Pharmacology and Therapeutics 1982; 15: 521–552
  • Hutabarat R. M., Yost G. S. Purification and characterization of an ethanol-induced UDP-giucuronosyltransferase. Archives of Biochemistry and Biophysics 1989; 273: 16–25
  • Ibshaid Y. M., Tephly T. R. Isolation and purification of two human liver UDP-glucuronosyltransferases. Molecular Pharmacology 1986; 31: 27–34
  • Iturriaga H., Ugarte G., Israel Y. Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients. European Journal of Clinical Investigation 1980; 10: 211–218
  • Iwamoto K., Klaassen C. The first pass effect of morphine in rats. Journal of Pharmacology and Experimental Therapeutics 1977; 200: 236–244
  • Lane E. A., Guthrie S., Linnoila M. Effects of ethanol on drug and metabolite pharmacokinetics. Clinical Pharmacokinetics 1985; 10: 228–247
  • Mahoney W. C., Hermodson M. A. Separation of large denatured peptides by reverse phase high performance liquid chromatography. Trifluoroacetic acid as a peptide solvent. Journal of Biological Chemistry 1980; 255: 11199–11203
  • Miners J. O., Lillywhite K. J., Birkett D. J. In vitro evidence for the involvement of at least two forms of human liver UDP-glucuronosyltransferase in morphine 3-glucuronidation. Biochemical Pharmacology 1988; 37: 2839–2845
  • Mount B. M., Melzack R., Macinnon K. J. The management of intractable pain in patients with advanced malignant disease. Journal of Urology 1978; 120: 720–725
  • Oguri K., Yamada-Mori I., Shigezane J., Hirano T., Yoshimura H. Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position. Life Science 1987; 41: 1457–1464
  • Osborne R. J., Joel S. P., Slevin M. L. Morphine intoxication in renal failure: the role of morphine-6-glucuronide. British Medical Journal 1986; 292: 1548–1549
  • Osborne R., Joel S., Trew D., Slevin M. Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clinical Pharmacology and Therapeutics 1990; 47: 12–19
  • Pasternak G. W., Bodnar R. J., Clark J. A., Inturrisi C. E. Morphine-6-glucuronide, a potent mu agonist. Life Science 1987; 41: 2845–2849
  • Sawe J., Svensson J.-O., Rane A. Morphine metabolism in cancer patients on increasing oral doses—no evidence for autoinduction or dose dependence. British Journal of Clinical Pharmacology 1983; 16: 85–93
  • Sawe J., Kager L., Svensson J.-O., Rane A. Oral morphine in cancer patients: in two kinetics and in vitro hepatic glucuronidation. British Journal of Clinical Pharmacology 1985; 19: 495–501
  • Stanski D. R., Greenblatt D. J., Lowenstein E. Kinetics of intravenous and intramuscular morphine. Clinical Pharmacology and Therapeutics 1978; 24: 52–59
  • Svensson J.-O., Rane A., Sawe J., Sjoqvist F. Determination of morphine, M3G and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography. Journal of Chrcmatography 1982; 230: 427–432
  • Wilkinson G. R., Shand D. G. A physiologic approach to hepatic drug clearance. Clinical Pharmacology and Therapeutics 1975; 18: 377–390
  • Yeh S. Y. Urinary excretion of morphine and its metabolites in morphine-dependent subjects. Journal of Pharmacology and Experimental Therapeutics 1974; 192: 201–210
  • Yoshimura H., Oguri K., Tsukamoto H. Metabolism of drugs—LX1I. Isolation and identification of morphine glucuronides in urine and bile of rabbits. Biochemical Pharmacology 1969; 18: 279–286
  • Yost G. S., Finley B. L. Sterecseiective glucuronidation as a probe of induced forms cf UDP-glucuronyitransferase in rabbits. Drug Metabolism and Disposition 1984; 13: 5–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.