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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 5
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Original Article

Disposition and metabolism of acetylcholinesterase reactivators 2PAM-I, TMB4 and R665 in rats submitted to organophosphate poisoning

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Pages 583-595 | Received 15 May 1990, Accepted 23 Nov 1990, Published online: 27 Aug 2009

References

  • Bay E., Krops S., Yates L. F. Chemotherapeutic effectiveness of 1,1-trimethylene-bis(4-formylpyridinium bromide) dioxime (TMB4) in experimental anticholinesterase poisoning. Proceedings of the Society for Experimental Biology and Medicine 1958; 98: 107–108
  • Clement G. H. Toxicology and pharmacology of bis-pyridinium oximes. Insight into the mechanism of action versus Soman poisoning in vivo. Fundamental Applied Pharmacology 1981; 55: 193–202
  • Clement G. H. HI6: reactivation of central and peripheral acetylcholinesterase following inhibition by Soman, Sarin and Tabun in vivo in the rat. Biochemical Pharmacology 1982; 31: 1283–1287
  • Coleman I. W., Little P. E., Grant G. A. Oxime mixtures and atropine in the protection of mice and rats from Sarin poisoning. Canadian Journal of Biochemistry and Physiology 1960; 38: 1053–1066
  • Garrigue H. Etude pharmacocinétique du methylsulfaté de pralidoxime administre par voie intramusculaire chez le rat et le lapin. 1982, Rapport interne CEB
  • Garrigue H., Maurizis J. C., Nicolas C., Madelmont J. C., Godeneche D., Hulot T., Morge X., Demerseman P., Sentenac-Roumanou H., Veyre A. Disposition and metabolism of two acetylcholinesterase reactivators, Pyrimidoxime and HI6, in rats submitted to organophosphate poisoning. Xenobiotica 1990; 20: 699–709
  • Gomeni R. 1988, S.I.M.E.D., 9–11 rue G. Enesco, 94008 Creteil, France
  • Green M. D., Jones D. E., Hilmas D. E. Sarin intoxication elevates plasma pralidoxime. Toxicology Letters 1985; 28: 17–21
  • Harris L. W., Fleischer J. H., Innrebner T. A., Cliff W. J., Sim V. M. The effect of Atropine-oxime therapy on cholinesterase activity on the survival of animals poisoned with O,O-diethyl-O-(2-isopropyl-6-methyl-methyl-4-pyrimidenyl) phosphorothioate. Toxicology and Applied Pharmacology 1969; 15: 216–224
  • Hobbiger F. Effect of nicotinhydroxamic acid methiodide on human plasma cholinesterase inhibited by organophosphates containing a dialkylphosphate group. British Journal of Pharmacology 1955; 10: 356–362
  • Hobbiger F. Reactivation of phosphorylated acetylcholinesterase by pyridine-2-aldoxime methiodide. Biochimica et Biophysica Acta 1957; 25: 652–654
  • Kiffer D., Minard P. Reactivation by imidazo-pyridinium oximes of acetylcholinesterase inhibited by organophosphates. Biochemical Pharmacology 1986; 35: 2527–2533
  • Kuhnen-Clausen D. Structure-activity relationship of mono and bis quaternary pyridines in regard to their parasympatholytic effects. Toxicology and Applied Pharmacology 1972; 23: 443–454
  • Levine R. R., Steinberg G. M. Intestinal absorption of pralidoxime and other aldoximes. Nature 1966; 5020: 269–271
  • Ligtenstein D. A., Kossen S. P. Kinetic profile in blood and brain tissue of the cholinesterase ractivating oxime HI6 after intravenous administration to the rat. Toxicology and Applied Pharmacology 1983; 71: 177–183
  • Ligtenstein D. A., Moes G. W., Kossen S. P. In vivo distribution of organosphosphate antidotes: autoradiography of 14C-HI6 in the rat. Toxicology and Applied Pharmacology 1988; 92: 324–329
  • Madelmont J. C., Nicolas C., Maurizis J. C., Dupuy J. M., Garrigue H., Meyniel J. M., Demerseman P., Sentenac-Roumanou H., Veyre A. Synthèse radioactive de sels d'ammonium quaternaires d'hydroxyminoethyl-2 ou -4 pyridinium par l'intermediaire de la N-methyl formanilide-14C: Marquages du 2PAM-iodure et du R665. Journal of Labelled Compounds 1990; 28: 1385–1392
  • Nicolas C., Madelmont J. C., Maurizis J. C., Garrigue H., Meyniel J. M., Demerseman P., Sentenac-Roumanou H., Veyre A. Synthèse radioactive de sels d'ammonium quaternaires d'hydroxy iminomethyl-2 ou -4 pyridinium au moyen de la N-methyl formanilide-14C: Marquage du HI6, du TMB4 et de la pyrimidoxime. Journal of Labelled Compounds 1990; 28: 1375–1383
  • Simonnard A. Contribution à l'étude toxicologique des sels de N-Alcoylimidazonium-Pyridinium-Carbamaldoximes, Thèse pour l'obtention du Doctoral d'Etat ès Sciences Pharmaceutiques. Université René Descartes, ParisFrance 1986
  • Simons K. J., Briggs C. J. Disposition of HI6 oxime in rats after intravenous and intrmuscular administration. Journal of Pharmacy and Pharmacology 1985; 37: 367–369
  • Ullberg S., Hammarstrom L., Appelgren L. E. The technics of whole-body autoradiography. International Encyclopedia of Pharmacology. Pergamon Press, Oxford 1971; 221–240
  • Usdin E. Reactions of cholinesterase with substrates inhibitors and reactivators. International Encyclopedia of Pharmacology and Therapeutics, section 13, vol. 1, Anticholinesterase Agents, A. G. Karczman. Pergamon Press, Oxford 1970; 354–367
  • Wilson J. R., Sondheimer P. A specific antidote against lethal alkyl phosphate intoxication, V, antidotal properties. Archives of Biochemistry and Biophysics 1957; 69: 468–474
  • Wolthuis O. L., Berends F., Meeter E. Problems in the therapy of Soman poisoning. Fundamental and Applied Toxicology 1981; 1: 183–192

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