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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 5
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Original Article

The sulphate conjugate of diflunisai: Its synthesis and systemic stability in the rat

R. G. Dickinson Department of Medicine of, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland, 4029, Australia
,
A. R. King Department of Medicine of, The University of Queensland, Royal Brisbane Hospital, Brisbane, Queensland, 4029, Australia
&
J. Hansen-Møller Department of Organic Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK-2100, Copenhagen, Denmark
Pages 635-640 | Received 17 Jul 1990, Published online: 27 Aug 2009

References

  • Dickinson R. G., King A. R. Reactivity considerations in the analysis of glucuronide and sulfate conjugates of diflunisal. Therapeutic Drug Monitoring 1989; 11: 712–720
  • Dickinson R. G., King A. R., Verbeeck R. K. Elimination of diflunisal as its acyl glucuronide, phenolic glucuronide and sulfate conjugates in bile-exteriorized and intact rats. Clinical and Experimental Pharmacology and Physiology 1989; 16: 913–924
  • Dickinson R. G., Verbeeck R. K., King A. R., Restifo A., Pond S. M. Diflunisal and its conjugates in patients with renal failure. British Journal of Clinical Pharmacology 1991, in press
  • Dieterle W., Faigle J. W., Mory H. Preparative reversed-phase chromatography of polar and non-polar metabolites on columns packed with micronized XAD-2 resin. Journal of Chromatography 1979; 162: 27–34
  • Hansen-Møller J., Dalgaard L., Hansen S. H. Reversed-phase high-performance liquid chromatographic assay for the simultaneous determination of diflunisal and its glucuronides in serum and urine. Rearrangement of the 1-O-acylglucuronide. Journal of Chromatography 1987; 420: 99–109
  • Hansen-Møller J., Cornett C., Dalgaard L., Hansen S. H. Isolation and identification of the rearrangement products of diflunisal 1-O-acyl glucuronide. Journal of Pharmaceutical and Biomedical Analysis 1988; 6: 229–240
  • Hashizume K., Yamatodani A., Yamamoto T., Wada H., Ogihara J. Contents of dopamine sulfoconjugate isomers and their desulfation in dog arteries. Biochemical Pharmacology 1989; 38: 1891–1895
  • Loewen G. R., Herman R. J., Ross S. G., Verbeeck R. K. Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies. British Journal of Clinical Pharmacology 1988; 26: 31–39
  • McKinnon G. E., Dickinson R. G. Covalent binding of diflunisal and probenecid to plasma protein in humans: persistence of the adducts in the circulation. Research Communications in Chemical Pathology and Pharmacology 1989; 66: 339–354
  • Muirhead M. R., Somogyi A. A., Lloyd C., Bochner F. Deconjugation of p-hydroxytriamterene sulphate in the rat. Xenobiotica 1989; 19: 655–660
  • Musson D. G., Lin J. H., Lyon K. A., Tocco D. J., Yeh K. C. Assay methodology for quantification of the ester and ether glucuronide conjugates of diflunisal in human urine. Journal of Chromatography 1985; 337: 363–378
  • Powell G. M., Olavesen A. H. The fate of sulfate esters in vivo. Sulfation of Drugs and Related Compounds, G. J. Mulder. CRC Press, Boca Raton, Florida 1981; 187–212
  • Verbeeck R. K., Dickinson R. G., Pond S. M. Biliary excretion of diflunisal conjugates in patients with T-tube drainage. European Journal of Clinical Pharmacology 1988; 34: 423–426
  • Watt J. A., Dickinson R. G. The effect of diethyl ether, pentobarbitone and urethane anaesthesia on diflunisal conjugation and disposition in rats. Biochemical Pharmacology 1990a; 39: 1067–1075
  • Watt J. A., Dickinson R. G. Effects of blockage of urine and/or bile flow on diflunisal conjugation and disposition in rats. Xenobiotica 1990b; 20: 835–845
  • Watt J. A., King A. R., Dickinson R. G. Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat. Xenobiotica 1990, in press

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