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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 5
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Original Article

Metabolism of low-dose paracetamol in patients with rheumatoid arthritis

H. Bradley School of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
,
R. H. Waring School of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
,
P. Emery Department of Rheumatology, University of Birmingham and Selly Oak Hospital, Birmingham, UK
&
V. Arthur Department of Rheumatology, University of Birmingham and Selly Oak Hospital, Birmingham, UK
Pages 689-693 | Received 14 Jun 1990, Accepted 06 Dec 1990, Published online: 27 Aug 2009

References

  • Carroll G. Measurement of sulphated glycosaminoglycans and proteoglycans in fragments in arthritic synovial fluid. Annals of the Rheumatic Diseases 1989; 48: 17–24
  • Clements J. A., Critchley J. A., Prescott L. F. The role of sulphate conjugation in the metabolism and disposition of oral and intravenous paracetamol in man. British Journal of Clinical Pharmacology 1984; 18: 481–485
  • Cooper A. J. Biochemistry of sulphur-containing amino acids. Annual Review of Biochemistry 1983; 53: 187–222
  • Critchley J. A., Nimmo G. R., Gregson C. A., Woolhouse N. M., Prescott L. F. Intersubject and ethnic differences in paracetamol metabolism. British Journal of Clinical Pharmacology 1986; 22: 649–657
  • Emery P., Panayi G. S., Huston G., Welsh K. L., Mitchell S. C., Shah R. R., Idle J. R., Smith R. L., Waring R. H. d-Penicillamine-induced toxicity in rhuematoid arthritis: the role of sulphoxidation status and HLA-DR3. Journal of Rheumatology 1984; 11: 626–632
  • Galinsky R. E., Slattery J. T., Levy G. Effect of sodium sulphate on acetaminophen elimination by rats. Journal of Pharmaceutical Sciences 1979; 68: 803–805
  • Howie D., Adriaenssens P. I., Phescott L. F. Paracetamol metabolism following overdosage: application of high performance liquid chromatography. Journal of Pharmacy and Pharmacology 1977; 29: 235–237
  • Lanthier P. L., Reshef R., Rashmikant R. S., Gates N. S., Smith R. L., Morgan M. Y. Oxidation phenotyping in alcoholics with liver disease of varying severity. Alcoholism: Clinical and Experimental Research 1984; 8: 435–441
  • Levy G., Yamada H. Drug biotransformation interactions in man III: acetaminophen and salicylamide. Journal of Pharmaceutical Sciences 1971; 60: 215–221
  • Mitchell S. C., Waring R. H. S-Oxygenases: III human pharmacogenetics. Sulphur-containing Drugs and Related Organic Compounds, L.-A. Damani. Ellis Horwood, Chichester 1989; Vol. 2A: 101–120
  • Morris M. E., Levy G. Serum concentration and renal excretion by normal adults of inorganic sulphate after acetaminophen, ascorbic acid or sodium sulphate. Clinical Pharmacology and Therapeutics 1983; 33: 529–536
  • Mucklow J. C., Fraser H. S., Bulpitt C. J., Kahn C., Mould G., Dollery C. T. Environmental factors affecting paracetamol metabolism in London factory and office workers. British Journal of Clinical Pharamcology 1980; 10: 67–74
  • Olomu A. B., Vickers C. R., Waring R. H., Clements D., Babbs C., Warnes T. W., Elias E. High incidence of poor sulphoxidation in patients with primary biliary cirrhosis. New England Journal of Medicine 1988; 318: 1089–1092
  • Prescott L. F. Kinetics and metabolism of paracetamol and phenacetin. British Journal of Clinical Pharmacology 1980; 10: 291S–298S
  • Steventon G. B., Heafield M. T. E., Waring R. H., Williams A. C., Sturman S., Green D. Metabolism of low-dose paracetamol in patients with chronic neurological disease. Xenobiotica 1990; 20: 117–122
  • Waring R. H. Mucolytic agents: cysteine derivatives. Sulphur-containing Drugs and Related Organic Compounds, L. A. Damani. Ellis Horwood, Chichester 1989; Vol. 3A: 87–108

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