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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 7
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Original Article

Effects of simvastatin, a lipoprotein-lowering drug, on the hepatic enzymes involved in drug metabolism in the Wistar rat

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Pages 859-864 | Received 02 Aug 1990, Accepted 01 Jan 1990, Published online: 27 Aug 2009

References

  • Black M., Billing B. H., Heirwegh K. P. M. Determination of bilirubin UDP-glucuronylsyltransferase activity in needle biopsy specimens of human liver. Clinica Chimica Acta 1970; 29: 27–32
  • Burke M. D., Mayer R. T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially induced by 3-methyl cholanthrene. Drug Metabolism and Disposition 1974; 2: 583–588
  • Colin-Neiger A., Kauffman P., Boutin J. A., Fournel S., Siest G., Batt A. M., Magdalou J. Assessment of the Mulder et Van Doom kinetic procedure and rapid centrifugal analysis of UDP-glucuronosyl transferase activities. Journal of Biochemical and Biophysical Methods 1984; 9: 69–70
  • Dansette P. M., Dubois C. C., Jerina P. M. Continuous fluorimetric assay for epoxide hydrolase activity. Analytical Biochemistry 1979; 97: 340–345
  • Folch J., Lees M., Sloane S. H. G. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 1957; 226: 497–509
  • Fournel S., Magdalou J., Siest G. Structure dependant induction of bilirubin glucuronidation and lauric acid 12-hydroxylation by aryl carboxylic acids related to cloftbrate. Biochima et Biophysica Acta 1985; 842: 202–213
  • Gardner R. S. A sensitive colorimetric assay for mitochondrial glycerol phosphate dehydrogenase. Analytical Biochemistry 1974; 59: 272–276
  • Goudonnet H., Mounie J., Truchot R. Effet de l'acide 3,5,3′ triodothryoacétique et de la dextrothyroxine sur l'activité de diverses enzymes microsomales hépatiques induites par le phénobarbital. Journal de Pharmacologie (Paris) 1978; 11: 347–364
  • Goudonnet H., Mounie J., Magdalou J., Escousse A., Truchot R. Comparative induction of rat liver bilirubin-UDPGT by ciprofibrate and other hypolipidaemic agents. Influence of thyroid status. Cellular and molecular aspects of glucuronidation. Collogue INSERM 1988; 173: 311–315
  • Greenlee W. F., Poland A. An improved assay of 7-ethoxycoumarin-O-deethylase activity. Journal of Pharmacology and Experimental Therapeutics 1978; 205: 596–605
  • Guengerich F. P., Donnan G. F. A., Wright S. T., Martin M. V., Kaminsky L. S. Purification and characterisation of liver microsomal cytochromes P450: electrophoresis, spectral, catalytic, and immunochemical properties and inducibility of eight enzymes isolated from rats treated with phenobarbital or β-naphthoflavone. Biochemistry 1982; 21: 6019–6030
  • Lazarrow P. B. Assay for peroxisomal β-oxidation of fatty acids. Methods in Enzymology, J. M. Lowenstein. Academic Press, New York 1981; vol. 72: 315–317
  • Lock E. A., Mitchell A. M., Elcombe C. R. Induction of hepatic peroxisome proliferation. Annual Review of Pharmacology and Toxicology 1989; 29: 145–163
  • Lowry D. H., Rosebrough J. N., Parr A. L., Randall R. J. Protein measurement with the Folin-phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Mol M., Erkelens D. W., Gevers J. A., Schouten J. A., Stalenhoef A. F. H. Simvastatin: A potent cholesterol synthesis inhibitor in heterozygous familial hypercholesterolaemia. Atherosclerosis 1988; 69: 131–137
  • Mulder G., Van Doorn A. A rapid NAD+-linked assay for microsomal UDP-glucuronosyl transferases of rat liver and some observations on substrate specificity of the enzyme. Biochemical Journal 1975; 151: 131–140
  • Oesch F., Daly J. W. Solubilization, purification and properties of a hepatic epoxide hydrolase. Biochimica et Biophysica Acta 1971; 227: 685–691
  • Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes. Journal of Biological Chemistry 1964; 239: 2370–2379
  • Schladt L., Hartmann C. T., Strollin-Benedetti M., Dostert P., Worner W., Oesch F. Concomitant induction of cytosolic but not microsomal epoxide hydrolase with peroxisomal β-oxidation by various hypolipidemic compounds. Biochemical Pharmacology 1987; 36: 345–351
  • Schulzeck P., Jochim A., Bojanovsky D., Bojanovsky M., Canzler H. Comparison between simvastatin and bezafibrate in effect on plasma lipoproteins and anolipoproteins in primary hypercholeterolaemia. Lancet 1983; 1(8586)611–613
  • Siest G., Batt A. M., Ziegler J. M. Les enzymes du métabolisme des médicaments. Lyon Pharmaceutique 1978; 29(5)347–364
  • Sharma R., Lake B. G., Foster J., Gibson G. G. Microsomal cytochrome P452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. Biochemical Pharmacology 1988; 37(7)1193–1201
  • Stahl E. Thin-layer chromatography; methods, influencing factors and an example of its use. Pharmazie 1973; 11: 633–637
  • Tobert J. A. New developments in lipids-lowering therapy: the role of inhibitors of hydroxymethylglutaryl CoA reductase. Circulation 1987; 76: 534–538
  • Truchot R., Goudonnet H., Mounieo J. Effets inducteurs sur le cytochrome P450 et la glycerolphosphate déshydrogénase hépatique chez le rat normal ou thyroïdectomisé, traité ou non par la L-T3. Journal de Pharmacologie (Paris) 1979; 10(4)325–336
  • Yoshino G., Kazumi T., Kasama T., Iwai M., Iwatani I., Matsuba K., Matsushita M., Baba S. Effects of CS-514 (pravastatine) on VLDL-triglycerides kinetics in rats. Atherosclerosis 1988; 73: 191–195

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