Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 7
16
Views
25
CrossRef citations to date
0
Altmetric
Original Article

Metabolism of 14C-dichloroethyne in rats

, , &
Pages 905-916 | Received 26 Aug 1990, Accepted 08 Feb 1991, Published online: 27 Aug 2009

References

  • Bakke J. E., Rafter J., Larsen G. L., Gustafsson J. A., Gostafsson B. E. Enterohepatic circulation of the mercapturic acid and cysteine conjugates of propachlor. Drug Metabolism and Disposition 1981; 9: 525–528
  • Bhattacharya R. K., Schultze M. O. Properties of DNA isolated from tissues of calves treated with S-(1,2-dichlorovinyl)-L-cysteine. I. Chemical and physical properties. Archives of Biochemistry and Biophysics 1971; 145: 565–574
  • Davison K. L., Bakke J. E., Larson G. L. Metabolism of the gluathione conjugate of propachlor by in situ perfused kidneys and livers of rats. Xenobiotica 1990; 20: 375–383
  • Dekant W., Martens G., Vamvakas S., Metzler M., Henschler D. Bioactivation of tetrachloroethylane—role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation. Drug Metabolism and Disposition 1987; 15: 702–709
  • Dekant W., Bertholo K., Vamvakas S., Henschler D., Anders M. W. Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate β-lyase. Chemical Research in Toxicology 1988; 1: 175–178
  • Dekant W., Vamvakas S., Anders M. W. Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: Formation of toxic and mutagenic intermediates by cysteine conjugate β-lyase. Drug Metabolism Reviews 1989; 210: 43–83
  • Dekant W., Koob M., Henschler D. Metabolism of trichloroethene—in vivo and in vitro evidence for activation by glutathione conjugation. Chemico-Biological Interactions 1990; 73: 89–101
  • De Montellano P. R. O., Kunze K. L. Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates. Journal of Biological Chemistry 1980; 255: 5578–5585
  • Eckert K.-G., Ever P. Formation and transport of xenobiotic glutathion-S-conjugates in red cells. Biochemical Pharmacology 1986; 33: 2299
  • Henschler D., Broser F., Hopf H. C. ‘Polyneuritis cranialis’ durch Vergiftung mit chlorierten Acetylenen beim Umgang mit Vinylidenchlorid-Copolymeren. Archives of Toxicology 1970; 26: 62
  • Humphrey J. H., McClelland M. Cranial nerve palsies with herpes following general anesthesia. British Medical Journal 1944; 1: 315
  • Ionue M., Okajima K., Morino Y. Hepato-renal cooperation in biotransformation, membrane transport, and elimination of cysteine s-conjugates of xenobiotics. Journal of Biochemistry 1984; 95: 247–254
  • Kanhai W., Dekant W., Henschler D. Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation. Chemical Research in Toxicology 1989; 2: 51–56
  • Lau S. S., Monks T. J. The in vivo disposition of 2-bromo-[14C]hydsroquinone and the effect of γ-glutamyl transpeptidase inhibition. Toxicology and Applied Pharmacology 1990; 103: 121–132
  • Meister A. Glutathione metabolism and its selective modification. Journal of Biological Chemistry 1988; 263: 17205–17208
  • Monks T. J., Anders M. W., Dekant W., Stevens J. L., Lau S. S., Van Bladeren P. J. Gluthathione conjugate mediated toxicities. Toxicology and Applied Pharmacology 1990, In press
  • Pekas J. C., Larsen G. L., Feil V. J. Propachlor detoxication in the small intestine: Cysteine conjugation. Journal of Toxicology and Environmental Health 1979; 5: 653–662
  • Pielichowski J., Popielarz R. Triochloroethylene in organic synthesis: I. A new, catalytic synthesis of dichloroacetylene. Synthesis 1984; 1984: 433–434
  • Rankin B. B., Curthoys N. P. Evidence for the renal paratubular transport of glutathione. FEES Letters 1982; 147: 193–196
  • Reichert D., Ewald D., Henschler D. Generation and inhalation toxicity of dichloroacetylene. Food and Cosmetics Toxicology 1975; 13: 511–515
  • Reichert D., Spengeler U., Romen W., Henschler D. Carcinogenicity of dichloroacetylene: an in inhalation study. Carcinogenesis 1984; 5: 1411–1420
  • Riemschneider R., Brendel K. Zur Kenntnis halogenierter Acetylene. Annalen der Chemie 1961; 640: 1
  • Saunders R. A. A hazard in closed environmental atmospheres. Archives of Environmental Health 1967; 14: 380
  • Siegel J., Jones R. A., Coon R. A., Lyon J. P. Effects on experimental animals of acute, repeated and continuous inhalation exposures to dichloroacetylene mixtures. Toxicology and Applied Pharmacology 1971; 18: 168–174
  • Tsao B., Curthoys N. P. The absolute asymetry of orientation of -glutamyltranspeptidase and aminopeptidase on the external surface of the rat renal brush border membrane. Journal of Biological Chemistry 1980; 255: 7708–7711
  • Vamvakas S., Dekant W., Berthold K., Schmidt S., Wild D., Henschler D. Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates. Biochemical Pharmacology 1987; 36: 2741–2748
  • Vamvakas S., Elfarra A. A., Dekant W., Henschler D., Anders M. W. Mutagenicity of amino acid and glutathione S-conjugates in the Ames test. Mutation Research 1988; 206: 83–90
  • Yllner S. Metabolism of 1,1,2,2-tetrachloroethane-14C in the mouse. Acta Pharmacologicae et Toxicologicae 1971; 29: 499–512

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.