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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 7
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Original Article

Metabolism of a new thiazolidinedione hypoglycemic agent CP-68,722 in rat: Metabolite identification by gas chromatography mass spectrometry

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Pages 925-934 | Received 09 Jul 1990, Accepted 06 Feb 1991, Published online: 27 Aug 2009

References

  • Clark D. A., Goldstein S. W., Hulin B., Volkmann R. A., Holland G. F., Eggler J. F., Johnson M. R., Krupp M. N., Stefvenson R. W., Kreutter D. K., Gibbs E. M., Hutson N. J. (1990) Synthesis and SAR of substituted dihydro-benzopyran and dihydro-benzofuran thiazolidine-2,4-diones for hypoglycemic activity. American Chemical Society Meeting Abstracts, MEDI 70, Boston, Massachusetts, April, 251990
  • Doi T., Tsukamoto T., Torïï H., Yoshida K., Tanayama S. Metabolism and disposition of 5-(3-ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione (CT-112), a new aldose reductase inhibitor in rats and dogs. Takeda Kenkyushoho 1984; 43(1/2)19–32
  • Eggler J. F., Holland G. F., Johnson M. R., Volkmann R. A. Hypoglycemic thiazolidinediones. US Patent. 4,703,052, 1982
  • Falkner F. C., Fouda H. G., Mullins F. G. A gas chromatographic/mass spectrometric assay for flutroline, a γ-carboline antipsychotic agent, with diret derivatization on a moving needle injector. Biomedical and Environmental Mass Spectrometry 1984; 11: 482–485
  • Fouda H. G., Lukaszewicz J., Luther E. W. Selected ion monitoring analysis of CP-55,940, a cannabinoid derived analgetic agent. Biomedical and Environmental Mass Spectrometry 1987; 14: 599–602
  • Hoffmann K. J., Weidolf L. Identification of felodipine metabolites in rat urine. Biomedical and Environmental Mass Spectrometry 1985; 12: 414–423
  • Kreutter D. K., Andrews K. M., Gibbs E. M., Stevenson R. W., Hutson N. J. Insulin-like activity of a new anti-hyperglycemic agent, CP-68,722, in 3T3-L1 adipocytes. Diabetologia 1989; 32: 506A
  • Levvy G. A., Conchie J. β-Glucuronidase and hydrolysis of glucuronides. Glucuronic Acid, Free and Combined, J. G. Dulton. Academic Press, New York 1966; 301–364
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Mori M., Matsuhashi T., Miyahara T., Shibata S., Izima C., Kozuka H. Reduction of 2,4-dinitrotoIuene by Wistar rat liver microsomal and cytosol fractions. Toxicology and Applied Pharmacology 1984; 76: 105–112
  • Stevenson R. W., Hutson N. J., Krupp M. N., Volkmann R. A., Holland G. F., Eggler J. F., Clark D. A., McPherson R. K., Hall K. L., Danbury B. H., Gibbs E. M., Kreutter D. K. Actions of the novel anti-diabetic agent CP-68,722 in the hyperglycemic, hyperinsulinemic ob/ob mouse. Diabetes 1990, in press
  • Yoshida K., Torïï H., Sugiyama Y., Fujita T., Tanayama S. Rat plasma metabolites of ciglitazone, a new antidiabetic agent. Xenobiotica 1984; 14(3)249–257

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