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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 7
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Original Article

Protein binding, nuclear translocation and biliary secretion of metabolites of 3′-methyl-N,N-dimethyl-4-aminoazobenzene during hepatocarcinogenesis in rats

K. Srinivasan Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, 10461, USA
,
W. G. Levine Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, 10461, USA
&
M. M. Bhargava Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, 10461, USA; Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York, 11042, USA
Pages 961-969 | Received 27 Jun 1990, Accepted 04 Jan 1991, Published online: 27 Aug 2009

References

  • Baldwin R. W., Barker C. R., Moore M. Distribution of a basic azo-dye binding prortein in normal rat tissues and carcinogen-induced hepatoma. British Journal of Cancer 1968; 22: 776–786
  • Bannikove G. A., Guelstein V. I., Tchipyseheva T. A. Distribution of basic azo-dye binding proteins in normal rat tissues and carcinogen-induced liver tumors. International Journal of Cancer 1973; 11: 398–411
  • Bhargava M. M., Ohmi N., Arias I. M., Becker F. F. Hepatocellular ligandin during N-2 fluorenylacetamide carcinogenesis. Oncology 1982; 39: 378–381
  • Blackburn G. R., Andrews J. P., Kesawa Rao K. V., Sorof S. An early event associated with liver carcinogenesis involving loss of a polypeptide that binds carcinogen. Cancer Research 1980; 40: 4688–4693
  • Blackburn G. R., Andrews J. P., Custer R. P., Sorof S. Early events during liver carcinogenesis involving two carcinogen: protein complexes. Cancer Research 1981; 41: 4039–4049
  • Blackburn G. R., Schnabel S. J., Danley J. M., Hogue-Angeletti R. A., Sorof S. Principal polypeptide target of carcinogen at the beginning of liver carcinogenesis by three carcinogens. Cancer Research 1982; 42: 4664–4672
  • Daoust R. Quantitative histology of rat liver during carcinogenesis by p-dimethylaminoazobenzene. Journal of National Cancer Institute 1961; 15: 1447–1449
  • Farber E., Parker S., Gruenstein E. The resistance of putative premalignant liver cell populations, hyperplastic nodules to the acute cytotoxic effects of some hepatocarcinogens. Cancer Research 1976; 36: 3879–3887
  • Firminger H. I., Reuber M. D. Influence of adrenocortical, androgenic and anabolic hormones on the development of carcinoma and cirrhosis of the liver in AXC rats fed N-2-Huorenyl diacetamide. Journal of National Cancer Institute 1961; 27: 559–595
  • Ketterer B. Interactions between carcinogens and proteins. Biology and Medicine Bulletin 1980; 36: 71–89
  • Ketterer B., Tipping W., Beale D., Meuwissen J., Kay C. M. Chemical and viral oncogenesis. Proceedings XI International Cancer Congress 1975; 2: 25–29
  • Mainigi D. K., Sorof S. Evidence for a receptor protein of activated carcinogen. Proceedings of the National Academy of Sciences, USA 1977; 74: 2293–2296
  • Mori Y., Hori T., Toyoshi K. Analysis of biliary and urinary metabolites of 3′-methyl-N,M-dimethyl-4-aminoazobenzene in rats. Gann 1978; 69: 757–762
  • Mori Y., Hori T., Toyoshi K. Carcinogenic azo dyes: detection of new metabolites of 3′-methyl-4-metJiylaminoazobenzene in rat bile. Radioisotopes 1979a; 28: 72–77
  • Mori Y., Yamamoto T., Toyoshi K. Carcinogenic azo dyes: Analysis of biliary and urinary metabolites of 3′-methyl-4-methylaminoazobenzene in rat. Chemistry and Pharmacy Bulletin (Tokyo) 1979b; 27: 379–385
  • Ohmi N., Bhargava M. M., Arias I. M. Binding of 3′-methyl-N,N-dimethyl-4-aminoazobenzene metabolites to rat liver cytosolic proteins and ligandin subunits. Cancer Research 1981; 41: 3461–3464
  • Samuels A. R., Bhargava M. M., Levine W. G. Uptake and hepatobiliary fate of two hepatocarcinogens, N,N-dimethyl-4–4 aminoazobenzene and 3′-methyl-N,N-dimethyl-4-aminoazobenzene in the rat. Cancer Research 1983; 43: 4816–4821
  • Samuels A. R., Freedman J., Bhargava M. M. Purification and characterization of a novel abundant protein in rat bile that binds azo dye metabolites and copper. Biochimica et Biophysica Acta 1983; 759: 23–31
  • Srinivasan K., Levine W. G., Bhargava M. M. Non-covalent binding of 3′-methyl-N,N-dimethyl-4-aminoazobenzene and its metabolites to liver cytosolic proteins and its role in their nuclear translocation. Drug Metabolism and Disposition 1987; 15: 504–510
  • Teebor G. W., Becker F. F. Regression and persistence of hyperplastic nodules induded by N-2-fluorenylacetamide and their relationship to hepatocarcinogenesis. Cancer Research 1971; 31: 1–3
  • Tierney B., Weaver D., Heintz N. H., Schaeffer W. I., Bresnick E. The identity and nuclear uptake of a cytosolic binding protein for 3-methylcholanthrene. Archives of Biochemistry and Biophysics 1980; 200: 513–523

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