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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 9
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Research Article

Methylation of captopril in human liver, kidney and intestine

G. M. Pacifici Department of Biomedicine, Medical School, University of Pisa, Via Roma 55, 55100, Pisa, Italy
,
S. Santerini Department of Surgery, Medical School, University of Pisa, Via Roma 55, 55100, Pisa, Italy
&
L. Giuliani Department of Surgery, Medical School, University of Pisa, Via Roma 55, 55100, Pisa, Italy
Pages 1107-1112 | Received 04 Aug 1990, Accepted 21 Feb 1991, Published online: 22 Sep 2008

References

  • Cohen A. I., Ivashkiv E., McCormick T., McKinstry D. N. Identification and determination of the S-methylmetabolite of captopril in human plasma by selected-ion monitoring gas chromatography-mass spectrometry. Journal of Pharmaceutical Sciences 1984; 73: 1493–1495
  • Drummer O. H., Jarrott B., Louis W. J. Demonstration of an S-methyl metabolite of captopril in patients undergoing chronic captopril therapy. Clinical and Experimental Pharmacology and Physiology 1982; 7: 81–86, Suppl
  • Dunchin K. L., McKinstry D. N., Cohen A. I., Migdalof B. H. Pharmacokinetics of captopril in healthy subjects and in patients with cardiovascular diseases. Clinical Pharmacokinetics 1988; 14: 241–259
  • Dunchin K. L., Singhvi S. M., Willard D. A., Migdalof B. H., McKinstry D. N. Captopril kinetics 1982; 31: 452–458
  • Keith R. A., Jardine I., Kerremans A., Weinshilboum R. M. Human erythrocite membrane thiol methyltransferase. Drug Metabolism and Disposition 1984; 12: 717–724
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Migdalof B. H., Singhvi S. M., Kripalani K. J. Thin-layer radiochromatographic determination of captopril (SQ 14,225) and its disulfide dimer metabolite in blood. Journal of Liquid Chromatography 1980; 3: 857–865
  • Pacifici G. M., Viani A., Franchi M., Gervasi P. G., Longo V., Di Simplicio P., Temellini A., Romiti P., Santerini S., Vannucci L., Mosca F. Profile of drug-mecabolizing enzymes in the cortex and medulla of the human liver. Pharmacology 1989; 39: 299–308
  • Wong K. K., Lan S. J., Migdalof B. H. In vitro biotransformation of 14C-captopril in the blood of rats, dogs, and humans. Biochemical Pharmacology 1981; 30: 2643–2650

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