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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 9
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Research Article

Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes

U. Christians Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
,
S. Strohmeyer Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
,
R. Kownatzki Zentrum Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
,
H.-M. Schiebel Institut für Organische Chemie, Technische Universität, Braunschweig, Germany
,
J. Bleck Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Hannover, Germany
,
K. Kohlhaw Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
,
R. Schottmann Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
&
K.-F. R. Sewing Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
 show all
Pages 1199-1210 | Received 18 Jan 1991, Accepted 09 Mar 1991, Published online: 22 Sep 2008

References

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  • Christians U., Zimmer K. O., Wonigeit K., Sewing K. F. Measurement of cyclosporin A and four of its metabolites in whole blood by high-performance liquid chromatography. Journal of Chromatography 1987; 413: 121–129
  • Christians U., Strohmeyer S., Kownatzki R., Schiebel H.-M., Bleck J., Greipel J., Kohlhaw K., Schottmann R., Sewing K.-F. Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile—Isolation of 12 new cyclosporine metabolites. Xenobiotica 1991; 21: 1185–1198
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  • Rosano T. G., Pell M. A., Freed B. M., Dybas M. T., Lempert N. Cyclosporine and metabolites in blood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: comparative high-performance liquid chromatography and monoclonal radioim-munoassay studies. Transplantation Proceedings 1988; 20: 330–338
  • Ryffel B., Foxwell B. M. J., Mihatsch M. J., Donatsch P., Maurer G. Biological significance of cyclosporine metabolites. Transplantation Proceedings 1988; 20: 575–584
  • Sewing K. F., Christians U., Kohlhaw K., Radeke H., Strohmeyer S., Kownatzki R., Budniax J., Schottmann R., Bleck J. S., Almeida V. M. F., Deters M., Wcnigeit K., Pichlmayr R. Biologic activity of cyclosporine metabolites. Transplantation Proceedings 1990; 22(3)1129–1134
  • Wallemacq P. E., Lhoëst G., Latinne D., de Bruyere M. Isolation, characterization and in vitro activity of cyclosporin A metabolites. Transplantation Proceedings 1989; 21: 906–910
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