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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
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Research Article

Pharmacokinetics of nizatidine in dogs and rats

H. Sano Central Research Laboratories, Zeria Pharmaceutical Co. Ltd, 2512–1 Oshikiri Kohnan-machi, Ohsato-gun, Saitama, 360-01, Japan
,
H. Sato Central Research Laboratories, Zeria Pharmaceutical Co. Ltd, 2512–1 Oshikiri Kohnan-machi, Ohsato-gun, Saitama, 360-01, Japan
,
S. Furuta Central Research Laboratories, Zeria Pharmaceutical Co. Ltd, 2512–1 Oshikiri Kohnan-machi, Ohsato-gun, Saitama, 360-01, Japan
,
M. Motogi Central Research Laboratories, Food and Drug Safety Center, 729-5 Ochiai, Hatano, Kanagawa, 257, Japan
&
Y. Matsuki Central Research Laboratories, Food and Drug Safety Center, 729-5 Ochiai, Hatano, Kanagawa, 257, Japan
Pages 1257-1264 | Received 26 Aug 1990, Accepted 08 Mar 1991, Published online: 22 Sep 2008

References

  • Azuma J., Sawamura A., Harada H., Hamaguchi T., Takebe M., Mochizuki N., Shinomiya M., Seto Y. Phase I study of Nizatidine (ZL-101) single oral administration. Japanese Pharmacology and Therapeutics 1989; 17: 495–524
  • Callaghan J. T., Bergstrom R. F., Obermeyer B. D. Pharmacokinetic-pharmacodynamic evaluation of nizatidine, a new H2 antagonist. Second World Conference on Clinical Pharmacology and Therapeutics. 1983, abstract 402
  • Evans D. C., Ruffolo R. R., Warrick M. W., Lin T. M. Specific histamine H2-receptor antagonist actions of nizatidine. Federation Proceedings 1984; 43(4)1074
  • Ings R. M. J. Interspecies scaling and comparisons in drug development and toxicokinetics. Xenobiotica 1990; 20(11)1201–1231
  • Knadler M. P., Bergstrom R. F., Callaghan J. T., Obermeyer B. D., Rubin A. Absorption studies of the H2-blocker nizatidine. Clinical Pharmacology and Therapeutics 1987; 42(5)514–520
  • Knadler M. P., Bergstrom R. F., Callaghan J. T., Rubin A. Nizatidine, an H2-blocker: its metabolism and disposition in man. Drug Metabolism and Disposition 1986; 14(2)175–182
  • Lin T. M., Evans D. C., Warrick M. W., Pioch R. P., Ruffolo R. R. Nizatidine, a new specific H2-receptor antagonist. Gastroenterology 1983; 84(5)1231
  • Lin T. M., Evans D. C., Warrick M. W., Pioch R. P. Actions of nizatidine on the rat uterus, dog stomach and experimentally induced gastric lesions. Journal of Pharmacology and Experimental Therapeutics 1986a; 239(2)400–405
  • Lin T. M., Evans D. C., Warrick M. W., Pioch R. P. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. Journal of Pharmacology and Experimental Therapeutics 1986b; 239(2)406–410
  • Morton D. M. Pharmacology and toxicology of nizatidine. Scandinavian Journal of Gastroenterology 1987; 22(Suppl. 136)1–8
  • Okabe S., Igata H., Takeda M., Tanaka T., Maeda K., Miyata H. Effects of nizatidine, a new histamine H2-receptor antagonist, on gastric acid secretion in Heidenhain pouch dogs. Therapeutic Research 1989; 10(1)337–342
  • Sano H., Sato H., Toyama S., Tagashira E., Esumi Y., Katam Y., Tohjo H., Yatsu S., Yokoshima T. Studies on the metabolic fate of nizatidine. I: Absorption, distribution, metabolism and excretion after a single administration to rats. Xenobiotic Metabolism and Disposition 1989a; 4(1)31
  • Sano H., Sato H., Toyama S., Tagashira E., Esumi Y., Katami Y., Tohjo H., Yatsu S., Yokoshima T. Studies on the metabolic fate of nizatidine. III: Absorption, metabolism and excretion in dogs. Xenobiotic Metabolism and Disposition 1989b; 4(1)55
  • Welage L. S., Grasera T. H., Thomas R. W., Wing D. E., Mueller G. A. The concentration effect relationship of nizatidine on stimulated gastric acid secretion. Clinical Pharmacology and Therapeutics 1987; 41(2)225
  • Yamaoka K., Tanigawara Y., Nakagawa T., Uno T. A pharmacokinetic analysis program (MULTI) for microcomputer. Journal of Pharmacobio-Dynamics 1981; 4: 879–885

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