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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
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Research Article

Biotransformation of 2-, 3-, and 4-methoxy-amphetamines by Cunninghamella echinulata

B. C. Foster Bureau of Drug Research, Sir Frederick Banting Research Centre, Health Protection Branch, Ottawa, Ontario, Canada, K1A 0L2
,
D. L. Litster Bureau of Drug Research, Sir Frederick Banting Research Centre, Health Protection Branch, Ottawa, Ontario, Canada, K1A 0L2
&
B. A. Lodge Bureau of Drug Research, Sir Frederick Banting Research Centre, Health Protection Branch, Ottawa, Ontario, Canada, K1A 0L2
Pages 1337-1346 | Received 18 Dec 1990, Accepted 03 Jun 1991, Published online: 22 Sep 2008

References

  • Bailey K., Beckstead H. D., Legault D., Verner D. Identification of 2-, 3-, and 4-methoxyamphetamines and 2-, 3-, and 4-methylamphetamines. Journal of the AOAC 1974; 57: 1134–1143
  • Clarke A. M., McChesney J. D., Hufford C. D. The use of microorganisms for the study of drug metabolism. Medicinal Research Reviews 1985; 5: 231–253
  • Coutts R. T., Foster B. C., Jones G. R., Myers G. E. Metabolism of N-(n-propyl)amphetamine by Cunninghamella echinulata. Applied and Environmental Microbiology 1979; 37: 429–432
  • Foster B. C., Coutts R. T., Passutto F. M. Biotransformation of aryl alkylamines by Cunninghamella bainieri. Xenobiotica 1989a; 19: 531–538
  • Foster B. C., Wilson D. L., McGilveray I. J. Effect of sparteine and quinidine on the metabolism of methoxyamphetamine by Cunninghamella bainieri. Xenobiotica 1989b; 19: 445–452
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  • Kitchen I., Tremblay J., Andre J., Dring L. G., Idle J. R., Smith R. L., Williams R. T. Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine. Xenobiotica 1979; 9: 397–404
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  • Merck Index11th edn., S. Budavari. Merck & Co., Rahway 1989; 763
  • Otton S. V., Brinn R. U., Gram L. F. In vitro evidence against the oxidation of quinidine by the sparteine/debrisoquine monooxygenase of human liver. Drug Metabolism and Disposition 1988; 16: 15–17
  • Rosazza J. P. N., Duffel M. W. Metabolic transformations of alkaloids. Alkaloids 1986; 27: 323–405
  • Rubin E. H., Gang H., Misra P. S., Lieber C. S. Inhibition of drug metabolism by acute ethanol intoxication. American Journal of Medicine 1970; 49: 801–806
  • Smith R. V., Rosazza J. P. Microbial models of mammalian metabolism. Journal of Pharmaceutical Sciences 1975; 64: 1737–1759

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